IR@PKUHSC  > 北京大学基础医学院  > 药理学系
学科主题基础医学
Promoting Effects of Ganoderma lucidum Polysaccharides on B16F10 Cells to Activate Lymphocytes
Sun, Li-Xin1,2; Lin, Zhi-Bin1; Li, Xue-Jun1; Li, Min1; Lu, Jie2; Duan, Xin-Suo2; Ge, Zhi-Hua2; Song, You-Xin2; Xing, En-Hong2; Li, Wei-Dong1
刊名BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
2011-03-01
DOI10.1111/j.1742-7843.2010.00632.x
108期:3页:149-154
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy ; Toxicology
研究领域[WOS]Pharmacology & Pharmacy ; Toxicology
关键词[WOS]INTERFERON-GAMMA ; ANTITUMOR-ACTIVITY ; MICE ; PROLIFERATION ; MECHANISMS ; RESPONSES ; RECEPTOR ; CD69
英文摘要

The immune system in patients with cancer often fails to control tumour growth because of deficient immunogenicity of tumour cells. Ganoderma lucidum polysaccharides (Gl-PS) are believed to have anti-tumour effects by boosting host immune function. Additionally, Gl-PS may have some direct effects on tumour cells in the activation of lymphocytes, thus enhancing the immunogenicity of tumour cells. We tested the effects of Gl-PS in lymphocyte activation by incubating Gl-PS with a tumour cell line deficient in antigen presentation. Our study showed that Gl-PS can promote B16F10 melanoma cells to induce lymphocyte proliferation, CD69 and FasL expression and IFN-gamma production, indicating that Gl-PS can improve the nature of B16F10 cells to activate lymphocytes. Furthermore, H-2Db [a major histocompatibility (MHC) class I molecule], and B7-1 and B7-2 (two prominent co-stimulatory molecules expressed on B16F10 cells) were enhanced by Gl-PS, suggesting that these molecules may at least partially be involved in the process of Gl-PS on B16F10 cells to activate lymphocytes.

语种英语
WOS记录号WOS:000287484000001
引用统计
被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54233
专题北京大学基础医学院_药理学系
北京大学基础医学院
作者单位1.Peking Univ, Dept Pharmacol, Hlth Sci Ctr, Sch Basic Med Sci, Beijing 100191, Peoples R China
2.Chengde Med Coll, Affiliated Hosp, Chengde, Hebei Province, Peoples R China
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Sun, Li-Xin,Lin, Zhi-Bin,Li, Xue-Jun,et al. Promoting Effects of Ganoderma lucidum Polysaccharides on B16F10 Cells to Activate Lymphocytes[J]. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY,2011,108(3):149-154.
APA Sun, Li-Xin.,Lin, Zhi-Bin.,Li, Xue-Jun.,Li, Min.,Lu, Jie.,...&Li, Wei-Dong.(2011).Promoting Effects of Ganoderma lucidum Polysaccharides on B16F10 Cells to Activate Lymphocytes.BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY,108(3),149-154.
MLA Sun, Li-Xin,et al."Promoting Effects of Ganoderma lucidum Polysaccharides on B16F10 Cells to Activate Lymphocytes".BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY 108.3(2011):149-154.
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