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学科主题: 基础医学
题名:
Promoting Effects of Ganoderma lucidum Polysaccharides on B16F10 Cells to Activate Lymphocytes
作者: Sun, Li-Xin1,2; Lin, Zhi-Bin1; Li, Xue-Jun1; Li, Min1; Lu, Jie2; Duan, Xin-Suo2; Ge, Zhi-Hua2; Song, You-Xin2; Xing, En-Hong2; Li, Wei-Dong1
刊名: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
发表日期: 2011-03-01
DOI: 10.1111/j.1742-7843.2010.00632.x
卷: 108, 期:3, 页:149-154
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy ; Toxicology
研究领域[WOS]: Pharmacology & Pharmacy ; Toxicology
关键词[WOS]: INTERFERON-GAMMA ; ANTITUMOR-ACTIVITY ; MICE ; PROLIFERATION ; MECHANISMS ; RESPONSES ; RECEPTOR ; CD69
英文摘要:

The immune system in patients with cancer often fails to control tumour growth because of deficient immunogenicity of tumour cells. Ganoderma lucidum polysaccharides (Gl-PS) are believed to have anti-tumour effects by boosting host immune function. Additionally, Gl-PS may have some direct effects on tumour cells in the activation of lymphocytes, thus enhancing the immunogenicity of tumour cells. We tested the effects of Gl-PS in lymphocyte activation by incubating Gl-PS with a tumour cell line deficient in antigen presentation. Our study showed that Gl-PS can promote B16F10 melanoma cells to induce lymphocyte proliferation, CD69 and FasL expression and IFN-gamma production, indicating that Gl-PS can improve the nature of B16F10 cells to activate lymphocytes. Furthermore, H-2Db [a major histocompatibility (MHC) class I molecule], and B7-1 and B7-2 (two prominent co-stimulatory molecules expressed on B16F10 cells) were enhanced by Gl-PS, suggesting that these molecules may at least partially be involved in the process of Gl-PS on B16F10 cells to activate lymphocytes.

语种: 英语
WOS记录号: WOS:000287484000001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54233
Appears in Collections:基础医学院_药理学系_期刊论文

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作者单位: 1.Peking Univ, Dept Pharmacol, Hlth Sci Ctr, Sch Basic Med Sci, Beijing 100191, Peoples R China
2.Chengde Med Coll, Affiliated Hosp, Chengde, Hebei Province, Peoples R China

Recommended Citation:
Sun, Li-Xin,Lin, Zhi-Bin,Li, Xue-Jun,et al. Promoting Effects of Ganoderma lucidum Polysaccharides on B16F10 Cells to Activate Lymphocytes[J]. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY,2011,108(3):149-154.
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