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Structural characterization of metabolites of salvianolic acid B from Salvia miltiorrhiza in normal and antibiotic-treated rats by liquid chromatography-mass spectrometry
Xu, Man; Guo, Hui; Han, Jian; Sun, Shi-Feng; Liu, Ai-Hua; Wang, Bao-Rong; Ma, Xiao-Chi; Liu, Peng; Qiao, Xue; Zhang, Zi-Chuan; Guo, De-An
关键词Salvianolic Acid b In Vivo Metabolites Lc-ms" Intestinal Bacterial Antibiotic-treated Rats
刊名JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
2007-10-15
DOI10.1016/j.jchromb.2007.08.032
858期:1-2页:184-198
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]MAGNESIUM LITHOSPERMATE-B ; SMOOTH-MUSCLE-CELLS ; BEAGLE DOG SERUM ; PHENOLIC-ACIDS ; HUMAN URINE ; IN-VITRO ; DIETARY POLYPHENOLS ; ROSMARINIC ACID ; ORGANIC-ACIDS ; HPLC-DAD
英文摘要

This study was conducted to compare the in vivo metabolites of salvianolic acid B (Sal B) between normal rats and antibiotic-treated rats and to clarify the role of intestinal bacteria on the absorption, metabolism and excretion of Sal B. A valid method using LC-MS" analysis was established for identification of rat biliary and fecal metabolites. And isolation of normal rat urinary metabolites by repeated column chromatography was applied in this study. Four biliary metabolites and five fecal metabolites in normal rats were identified on the basis of their MS′ fragmentation patterns. Meanwhile, two normal rat urinary metabolites were firstly identified on the basis of their NMR and MS data. In contrast, no metabolites were detected in antibiotic-treated rat urine and bile, while the prototype of Sal B was found in antibiotic-treated rat feces. The differences of in vivo metabolites between normal rats and antibiotic-treated rats were proposed for the first time. Furthermore, it was indicated that the intestinal bacteria showed an important role on the absorption, metabolism and excretion of Sal B. This investigation provided scientific evidence to infer the active principles responsible for the pharmacological effects of Sal B. (C) 2007 Published by Elsevier B.V.

语种英语
WOS记录号WOS:000250608200024
引用统计
被引频次:28[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54234
专题北京大学药学院
作者单位Peking Univ, Ctr Hlth Sci, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
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Xu, Man,Guo, Hui,Han, Jian,et al. Structural characterization of metabolites of salvianolic acid B from Salvia miltiorrhiza in normal and antibiotic-treated rats by liquid chromatography-mass spectrometry[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,2007,858(1-2):184-198.
APA Xu, Man.,Guo, Hui.,Han, Jian.,Sun, Shi-Feng.,Liu, Ai-Hua.,...&Guo, De-An.(2007).Structural characterization of metabolites of salvianolic acid B from Salvia miltiorrhiza in normal and antibiotic-treated rats by liquid chromatography-mass spectrometry.JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,858(1-2),184-198.
MLA Xu, Man,et al."Structural characterization of metabolites of salvianolic acid B from Salvia miltiorrhiza in normal and antibiotic-treated rats by liquid chromatography-mass spectrometry".JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 858.1-2(2007):184-198.
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