学科主题临床医学
Expression of cancer/testis (CT) antigens in Chinese hepatocellular carcinoma and its correlation with clinical parameters
Peng, JR; Chen, HS; Mou, DC; Cao, J; Cong, X; Qin, LL; Wei, L; Leng, XS; Wang, Y; Chen, WF
关键词Cancer/testis Antigen Hepatocellular Carcinoma Clinical Parameter
刊名CANCER LETTERS
2005-03-10
DOI10.1016/j.canlet.2004.07.028
219期:2页:223-232
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]TUMOR-REJECTION ANTIGENS ; SQUAMOUS-CELL CARCINOMA ; ALPHA-FETOPROTEIN GENE ; DNA METHYLATION ; MAGE GENES ; CANCER ; MELANOMA ; FAMILY ; NY-ESO-1 ; REGION
英文摘要

For investigating the expression of cancer/testis (CT) antigens in patients with hepatocellular carcinoma (HCC) in China, and evaluating the correlations between the expression of these CT antigens and clinical parameters, we collected tumors and adjacent non-cancerous tissues of 43 HCC patients from Beijing and 30 HCC patients from Guangxi province. Expression of the mRNA of 14 CT antigens was evaluated by reverse transcription PCR (RT-PCR). The correlation between CT antigen expression and clinical parameters was statistically analyzed. The mRNA expression frequencies of CT antigens in tumor tissue were: MAGE-A1, 69.9%; MAGE-A3,47.9%; MAGE-A4,20.0%; MAGE-A10, 36.7%; SSX-1, 67.4%; SSX-2,35.6%; SSX-4, 48.8%; SSX-5, 30.2%; NY-ESO-1, 42.5%; MAGE-B 1, 52.0%; MAGE-B2,60.0%; MAGE-C 1, 48.0%; MAGE-C2,68.0%; and SCP-1, 33.3%. However, in adjacent tissues, no CT antigen mRNA expression was detected, except SSX-1 in 9.3% patients. In each HCC tissue, the expression of a minimum of one, two, or three CT antigens was in the range of 80-90, 70-80 or 50-70%, respectively. MAGE-A3 mRNA expression differed between the HCC patients in Beijing and Guangxi (P = 0.002). The average age of the HCC patients bearing CT antigen positive tumors was higher than that of the HCC patients bearing CT antigen negative tumors. The expression of MAGE-A3, SSX-1, SSX-2, SSX-4, MAGE-B2, MAGE-Cl, and MAGE-C2 correlated significantly with older age (P < 0.05). Moreover, the expressions of MAGE-A4 and SCP-1 were related to alphafetoprotein abnormality (P < 0.05), and the expression of NY-ESO-1 was related to early tumor stage (P < 0.05). There was no correlation observed between the expression of CT antigens and the sex, HBV infection or tumor size. (c) 2004 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000227766700013
引用统计
被引频次:56[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54239
专题北京大学第二临床医学院_北京大学肝病研究所
作者单位1.Peking Univ, Hlth Sci Ctr, Peoples Hosp, Inst Hepatol, Beijing 100044, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Peoples Hosp, Ctr Hepatobiliary Surg, Beijing 100044, Peoples R China
3.Guangxi Med Univ, Affiliated Tumor Hosp, Dept Pathol, Nanning 530021, Guangxi, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Immunol, Sch Basic Med Sci, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Peng, JR,Chen, HS,Mou, DC,et al. Expression of cancer/testis (CT) antigens in Chinese hepatocellular carcinoma and its correlation with clinical parameters[J]. CANCER LETTERS,2005,219(2):223-232.
APA Peng, JR.,Chen, HS.,Mou, DC.,Cao, J.,Cong, X.,...&Chen, WF.(2005).Expression of cancer/testis (CT) antigens in Chinese hepatocellular carcinoma and its correlation with clinical parameters.CANCER LETTERS,219(2),223-232.
MLA Peng, JR,et al."Expression of cancer/testis (CT) antigens in Chinese hepatocellular carcinoma and its correlation with clinical parameters".CANCER LETTERS 219.2(2005):223-232.
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