北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 北京大学肝病研究所  > 期刊论文
学科主题: 临床医学
题名:
Expression of cancer/testis (CT) antigens in Chinese hepatocellular carcinoma and its correlation with clinical parameters
作者: Peng, JR; Chen, HS; Mou, DC; Cao, J; Cong, X; Qin, LL; Wei, L; Leng, XS; Wang, Y; Chen, WF
关键词: cancer/testis antigen ; hepatocellular carcinoma ; clinical parameter
刊名: CANCER LETTERS
发表日期: 2005-03-10
DOI: 10.1016/j.canlet.2004.07.028
卷: 219, 期:2, 页:223-232
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: TUMOR-REJECTION ANTIGENS ; SQUAMOUS-CELL CARCINOMA ; ALPHA-FETOPROTEIN GENE ; DNA METHYLATION ; MAGE GENES ; CANCER ; MELANOMA ; FAMILY ; NY-ESO-1 ; REGION
英文摘要:

For investigating the expression of cancer/testis (CT) antigens in patients with hepatocellular carcinoma (HCC) in China, and evaluating the correlations between the expression of these CT antigens and clinical parameters, we collected tumors and adjacent non-cancerous tissues of 43 HCC patients from Beijing and 30 HCC patients from Guangxi province. Expression of the mRNA of 14 CT antigens was evaluated by reverse transcription PCR (RT-PCR). The correlation between CT antigen expression and clinical parameters was statistically analyzed. The mRNA expression frequencies of CT antigens in tumor tissue were: MAGE-A1, 69.9%; MAGE-A3,47.9%; MAGE-A4,20.0%; MAGE-A10, 36.7%; SSX-1, 67.4%; SSX-2,35.6%; SSX-4, 48.8%; SSX-5, 30.2%; NY-ESO-1, 42.5%; MAGE-B 1, 52.0%; MAGE-B2,60.0%; MAGE-C 1, 48.0%; MAGE-C2,68.0%; and SCP-1, 33.3%. However, in adjacent tissues, no CT antigen mRNA expression was detected, except SSX-1 in 9.3% patients. In each HCC tissue, the expression of a minimum of one, two, or three CT antigens was in the range of 80-90, 70-80 or 50-70%, respectively. MAGE-A3 mRNA expression differed between the HCC patients in Beijing and Guangxi (P = 0.002). The average age of the HCC patients bearing CT antigen positive tumors was higher than that of the HCC patients bearing CT antigen negative tumors. The expression of MAGE-A3, SSX-1, SSX-2, SSX-4, MAGE-B2, MAGE-Cl, and MAGE-C2 correlated significantly with older age (P < 0.05). Moreover, the expressions of MAGE-A4 and SCP-1 were related to alphafetoprotein abnormality (P < 0.05), and the expression of NY-ESO-1 was related to early tumor stage (P < 0.05). There was no correlation observed between the expression of CT antigens and the sex, HBV infection or tumor size. (c) 2004 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000227766700013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54239
Appears in Collections:北京大学第二临床医学院_北京大学肝病研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Hlth Sci Ctr, Peoples Hosp, Inst Hepatol, Beijing 100044, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Peoples Hosp, Ctr Hepatobiliary Surg, Beijing 100044, Peoples R China
3.Guangxi Med Univ, Affiliated Tumor Hosp, Dept Pathol, Nanning 530021, Guangxi, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Immunol, Sch Basic Med Sci, Beijing 100083, Peoples R China

Recommended Citation:
Peng, JR,Chen, HS,Mou, DC,et al. Expression of cancer/testis (CT) antigens in Chinese hepatocellular carcinoma and its correlation with clinical parameters[J]. CANCER LETTERS,2005,219(2):223-232.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Peng, JR]'s Articles
[Chen, HS]'s Articles
[Mou, DC]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Peng, JR]‘s Articles
[Chen, HS]‘s Articles
[Mou, DC]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace