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学科主题临床医学
Astragali and Angelica protect the kidney against ischemia and reperfusion injury and accelerate recovery
Cai, Q; Li, XM; Wang, HY
关键词Astragali And Angelica Ischemia And Reperfusion Signal Transduction
刊名CHINESE MEDICAL JOURNAL
2001-02-01
114期:2页:119-123
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]JUN ; KINASES ; MAPKS
英文摘要

Objective To investigate the role of Astragali and Angelica (A&A) of Chinese herbs in acute renal ischemia/reperfusion injury, and the related intracellular signal transduction mechanism.

Methods Acute ischemic renal injury in rats was induced by clamping in renal pedicel for 45 minutes. Rats in therapy group were given a single dose (2 ml/day) of A&A for 3 days before clamping, and then continued for another 3 days. Forty-five minutes after clamping and at different reperfusion time, serum creatinine (Scr) and renal pathological changes were taken and compared in both groups. The proliferating cell nuclear antigen (PCNA) positive cells were detected by immunohistochemistry. Extracelluar regulating kinase (ERK) and c-Jun N-terminal kinase (JNK) activity was assayed by specific substrate phosphorylation with immunoprecipitation.

Results At the 24th hour of reperfusion, Scr was lower in A&A group than that in the control. Much less necrotic tubular cells, casts, and more PCNA-positive cells were found in A&A group. ERK activity decreased after clamping, and recovered at 5 minutes of reperfusion. There was no difference between the two groups. JNK activity did not change after ischemia, but increased at 5 minutes and peaked at 20 minutes of reperfusion. JNK activity was significantly higher in A&A group than that in the control group.

Conclusion A&A protected kidney against ischemic insult and accelerated both functional and histological recovery after acute renal ischemia/reperfusion injury, which may associate with the change of JNK signaling pathway.

语种英语
WOS记录号WOS:000167246700002
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54243
专题北京大学第一临床医学院_肾脏内科
作者单位1.Beijing Med Univ, Hosp 1, Dept Med, Div Renal, Beijing 100034, Peoples R China
2.Beijing Med Univ, Hlth Sci Ctr, Inst Nephrol, Beijing 100034, Peoples R China
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GB/T 7714
Cai, Q,Li, XM,Wang, HY. Astragali and Angelica protect the kidney against ischemia and reperfusion injury and accelerate recovery[J]. CHINESE MEDICAL JOURNAL,2001,114(2):119-123.
APA Cai, Q,Li, XM,&Wang, HY.(2001).Astragali and Angelica protect the kidney against ischemia and reperfusion injury and accelerate recovery.CHINESE MEDICAL JOURNAL,114(2),119-123.
MLA Cai, Q,et al."Astragali and Angelica protect the kidney against ischemia and reperfusion injury and accelerate recovery".CHINESE MEDICAL JOURNAL 114.2(2001):119-123.
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