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学科主题临床医学
Emerging role of high mobility group box 1 in ANCA-associated vasculitis
Wang, Chen1; de Souza, Alexandre W. S.2,3; Westra, Johanna2; Bijl, Marc4; Chen, Min1; Zhao, Ming-Hui1; Kallenberg, Cees G. M.2
关键词Hmgb1 Inflammation Vasculitis Anca
刊名AUTOIMMUNITY REVIEWS
2015-11-01
DOI10.1016/j.autrev.2015.07.010
14期:11页:1057-1065
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Immunology
研究领域[WOS]Immunology
关键词[WOS]TOLL-LIKE RECEPTORS ; ANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODIES ; ANTIBODY-ASSOCIATED VASCULITIS ; GLYCATION END-PRODUCTS ; ALTERNATIVE COMPLEMENT PATHWAY ; HENOCH-SCHONLEIN PURPURA ; SMALL-VESSEL VASCULITIS ; VEIN ENDOTHELIAL-CELLS ; REGULATORY T-CELLS ; SERUM HMGB1 LEVELS
英文摘要

High mobility group box 1 (HMGB1) has been suggested to be involved in the pathogenesis of many autoimmune diseases. In addition to its nuclear functions, extracellular HMGB1 released from activated, injured or dying cells becomes a proinflammatory mediator via binding to various receptors on the surface of responding cells. HMGB1 interacts with various systems involved in inflammation, such as the complement system and the coagulation system. Thus, HMGB1 could amplify inflammation and enhance immune responses in pathophysiology of certain diseases. In the past years, HMGB1 has been studied in several vasculitides including antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis, Kawasaki disease, Henoch-Schonlein purpura, Takayasu arteritis and giant cell arteritis. Several studies showed that circulating HMGB1 levels are higher in patients with active disease compared with healthy controls, and levels are associated with disease severity. Further studies on pathogenetic mechanisms revealed pathogenic roles of HMGB1 in some vasculitides. Here we review clinical and experimental studies dealing with the role of HMGB1 in vascular inflammation, and its relation to the manifestations and prognosis of specific vasculitides, in particular ANCA-associated vasculitis. (C) 2015 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000361861200010
项目编号2012CB517702 ; 81425008 ; 81321064 ; 81300599 ; 2011BAI10B04
资助机构Chinese 973 project ; National Natural Science Fund ; "National Key Technology Research and Development (R&amp ; D) Program" of the Ministry of Science and Technology of China
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54245
专题北京大学第一临床医学院_肾脏内科
作者单位1.Martini Hosp, Groningen, Netherlands
2.Peking Univ, Hosp 1, Div Renal, Beijing 100034, Peoples R China
3.Univ Groningen, Univ Med Ctr Groningen, Dept Rheumatol & Clin Immunol, NL-9700 AB Groningen, Netherlands
4.Univ Fed Sao Paulo, Div Rheumatol, Sao Paulo, Brazil
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Wang, Chen,de Souza, Alexandre W. S.,Westra, Johanna,et al. Emerging role of high mobility group box 1 in ANCA-associated vasculitis[J]. AUTOIMMUNITY REVIEWS,2015,14(11):1057-1065.
APA Wang, Chen.,de Souza, Alexandre W. S..,Westra, Johanna.,Bijl, Marc.,Chen, Min.,...&Kallenberg, Cees G. M..(2015).Emerging role of high mobility group box 1 in ANCA-associated vasculitis.AUTOIMMUNITY REVIEWS,14(11),1057-1065.
MLA Wang, Chen,et al."Emerging role of high mobility group box 1 in ANCA-associated vasculitis".AUTOIMMUNITY REVIEWS 14.11(2015):1057-1065.
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