北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 肾脏内科  > 期刊论文
学科主题: 临床医学
题名:
Emerging role of high mobility group box 1 in ANCA-associated vasculitis
作者: Wang, Chen1; de Souza, Alexandre W. S.2,3; Westra, Johanna2; Bijl, Marc4; Chen, Min1; Zhao, Ming-Hui1; Kallenberg, Cees G. M.2
关键词: HMGB1 ; Inflammation ; Vasculitis ; ANCA
刊名: AUTOIMMUNITY REVIEWS
发表日期: 2015-11-01
DOI: 10.1016/j.autrev.2015.07.010
卷: 14, 期:11, 页:1057-1065
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: TOLL-LIKE RECEPTORS ; ANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODIES ; ANTIBODY-ASSOCIATED VASCULITIS ; GLYCATION END-PRODUCTS ; ALTERNATIVE COMPLEMENT PATHWAY ; HENOCH-SCHONLEIN PURPURA ; SMALL-VESSEL VASCULITIS ; VEIN ENDOTHELIAL-CELLS ; REGULATORY T-CELLS ; SERUM HMGB1 LEVELS
英文摘要:

High mobility group box 1 (HMGB1) has been suggested to be involved in the pathogenesis of many autoimmune diseases. In addition to its nuclear functions, extracellular HMGB1 released from activated, injured or dying cells becomes a proinflammatory mediator via binding to various receptors on the surface of responding cells. HMGB1 interacts with various systems involved in inflammation, such as the complement system and the coagulation system. Thus, HMGB1 could amplify inflammation and enhance immune responses in pathophysiology of certain diseases. In the past years, HMGB1 has been studied in several vasculitides including antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis, Kawasaki disease, Henoch-Schonlein purpura, Takayasu arteritis and giant cell arteritis. Several studies showed that circulating HMGB1 levels are higher in patients with active disease compared with healthy controls, and levels are associated with disease severity. Further studies on pathogenetic mechanisms revealed pathogenic roles of HMGB1 in some vasculitides. Here we review clinical and experimental studies dealing with the role of HMGB1 in vascular inflammation, and its relation to the manifestations and prognosis of specific vasculitides, in particular ANCA-associated vasculitis. (C) 2015 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 2012CB517702 ; 81425008 ; 81321064 ; 81300599 ; 2011BAI10B04
项目资助者: Chinese 973 project ; National Natural Science Fund ; "National Key Technology Research and Development (R&amp ; D) Program" of the Ministry of Science and Technology of China
WOS记录号: WOS:000361861200010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54245
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Martini Hosp, Groningen, Netherlands
2.Peking Univ, Hosp 1, Div Renal, Beijing 100034, Peoples R China
3.Univ Groningen, Univ Med Ctr Groningen, Dept Rheumatol & Clin Immunol, NL-9700 AB Groningen, Netherlands
4.Univ Fed Sao Paulo, Div Rheumatol, Sao Paulo, Brazil

Recommended Citation:
Wang, Chen,de Souza, Alexandre W. S.,Westra, Johanna,et al. Emerging role of high mobility group box 1 in ANCA-associated vasculitis[J]. AUTOIMMUNITY REVIEWS,2015,14(11):1057-1065.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wang, Chen]'s Articles
[de Souza, Alexandre W. S.]'s Articles
[Westra, Johanna]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wang, Chen]‘s Articles
[de Souza, Alexandre W. S.]‘s Articles
[Westra, Johanna]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace