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学科主题: 药学
题名:
An alternative paclitaxel microemulsion formulation: hypersensitivity evaluation and pharmacokinetic profile
作者: He, L; Wang, GL; Zhang, Q
关键词: paclitaxel ; microemulsion ; taxol ; cremophor EL ; hypersensitivity ; phamacokinetics
刊名: INTERNATIONAL JOURNAL OF PHARMACEUTICS
发表日期: 2003-01-02
卷: 250, 期:1, 页:45-50
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
英文摘要:

Based on the clinical fact that paclitaxel injection (Taxol(R)) frequently causes hypersensitivity reactions, we prepared an alternative paclitaxel microemulsion with small particle size (17.2 nm). The hypersensitivity evaluation and pharmacokinetic behavior in rats were conducted to assess the new microemulsion. The results showed that the new microemulsion was negative and the placebo Taxol(R) solution was positive with regard to allergic reactions. In the pharmacokinetic study, five rats were administrated Taxol(R) or paclitaxel microemulsion. Blood samples were collected at 0, 0.25, 0.5, 1, 2, 4, 6, 8, 10, 12, 14 h and paclitaxel determined by HPLC. The area under the curve (AUC) was significantly higher in the microemulsion group (34.98 mug ml(-1) h) than that in the Taxol(R) group (21.98 mug ml(-1) h). Also, the K-10 was much smaller in the microemulsion group (0.57 h(-1)) compared with the Taxol(R) group (1.29 h(-1)), showing the elimination rate was much slower in the former than in the latter. Compared with Taxol(R), the paclitaxel microemulsion caused less toxicity and had a longer circulation time in rats. (C) 2002 Elsevier Science B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000180565600005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54246
Appears in Collections:北京大学药学院_药剂学系_期刊论文

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作者单位: Peking Univ, Dept Pharmaceut, Sch Pharmaceut Sci, Beijing 100083, Peoples R China

Recommended Citation:
He, L,Wang, GL,Zhang, Q. An alternative paclitaxel microemulsion formulation: hypersensitivity evaluation and pharmacokinetic profile[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2003,250(1):45-50.
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