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An alternative paclitaxel microemulsion formulation: hypersensitivity evaluation and pharmacokinetic profile
He, L; Wang, GL; Zhang, Q
关键词Paclitaxel Microemulsion Taxol Cremophor El Hypersensitivity Phamacokinetics
刊名INTERNATIONAL JOURNAL OF PHARMACEUTICS
2003-01-02
250期:1页:45-50
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
英文摘要

Based on the clinical fact that paclitaxel injection (Taxol(R)) frequently causes hypersensitivity reactions, we prepared an alternative paclitaxel microemulsion with small particle size (17.2 nm). The hypersensitivity evaluation and pharmacokinetic behavior in rats were conducted to assess the new microemulsion. The results showed that the new microemulsion was negative and the placebo Taxol(R) solution was positive with regard to allergic reactions. In the pharmacokinetic study, five rats were administrated Taxol(R) or paclitaxel microemulsion. Blood samples were collected at 0, 0.25, 0.5, 1, 2, 4, 6, 8, 10, 12, 14 h and paclitaxel determined by HPLC. The area under the curve (AUC) was significantly higher in the microemulsion group (34.98 mug ml(-1) h) than that in the Taxol(R) group (21.98 mug ml(-1) h). Also, the K-10 was much smaller in the microemulsion group (0.57 h(-1)) compared with the Taxol(R) group (1.29 h(-1)), showing the elimination rate was much slower in the former than in the latter. Compared with Taxol(R), the paclitaxel microemulsion caused less toxicity and had a longer circulation time in rats. (C) 2002 Elsevier Science B.V. All rights reserved.

语种英语
WOS记录号WOS:000180565600005
引用统计
被引频次:53[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54246
专题北京大学药学院_药剂学系
作者单位Peking Univ, Dept Pharmaceut, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
He, L,Wang, GL,Zhang, Q. An alternative paclitaxel microemulsion formulation: hypersensitivity evaluation and pharmacokinetic profile[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2003,250(1):45-50.
APA He, L,Wang, GL,&Zhang, Q.(2003).An alternative paclitaxel microemulsion formulation: hypersensitivity evaluation and pharmacokinetic profile.INTERNATIONAL JOURNAL OF PHARMACEUTICS,250(1),45-50.
MLA He, L,et al."An alternative paclitaxel microemulsion formulation: hypersensitivity evaluation and pharmacokinetic profile".INTERNATIONAL JOURNAL OF PHARMACEUTICS 250.1(2003):45-50.
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