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学科主题: 基础医学
题名:
Morphine-induced conditioned place preference in rats is inhibited by electroacupuncture at 2 Hz: Role of enkephalin in the nucleus accumbens
作者: Liang, Jing1,2; Ping, Xing-Jie1,2; Li, Yi-Jing1,2; Ma, Yao-Ying1,2; Wu, Liu-Zhen1,2; Han, Ji-Sheng1,2; Cui, Cai-Lian1,2
关键词: Morphine ; Conditioned place preference ; Nucleus accumbens ; Enkephalin ; Electroacupuncture
刊名: NEUROPHARMACOLOGY
发表日期: 2010
DOI: 10.1016/j.neuropharm.2009.07.007
卷: 58, 期:1, 页:233-240
收录类别: SCI ; ISTP
文章类型: Proceedings Paper
WOS标题词: Science & Technology
类目[WOS]: Neurosciences ; Pharmacology & Pharmacy
研究领域[WOS]: Neurosciences & Neurology ; Pharmacology & Pharmacy
关键词[WOS]: OPIOID-RECEPTORS ; ENDOGENOUS LIGANDS ; INDUCED CPP ; BRAIN ; KAPPA ; EXPRESSION ; DRUG ; STIMULATION ; MICRODIALYSIS ; REINSTATEMENT
英文摘要:

Our previous studies have demonstrated that morphine-induced conditioned place preference (CPP) can be inhibited by 2 Hz electroacupuncture (EA). This inhibition can be blocked by either the opioid receptor antagonist naloxone (i.p.) or lesion in the nucleus accumbens (NAc), providing evidence that endogenous opioid system in the NAc mediates the effects of EA. Here we report that 1) A single session of 2 Hz EA produced a significant increase of the content of enkephalin in the NAc of morphine-induced CPP rats, and this effect was stronger in three consecutive sessions of EA; 2) Intracerebroventricular injection of the mu-opioid receptor antagonist CTAP or delta-opioid receptor antagonist NTI, but not kappa-opioid receptor antagonist nor-BNI, dose-dependently reversed the inhibitory effects of 2 Hz EA on the expression of morphine-induced CPP; 3) Three consecutive sessions of 2 Hz EA up-regulated the mRNA level of preproenkephalin in the NAc of morphine-induced CPP rats. The results suggest that the inhibitory effects of 2 Hz EA on the expression of the morphine CPP is mediated by mu- and delta-, but not kappa-opioid receptor, possibly via accelerating both the release and synthesis of enkephalin in the NAc. These findings support the possibility of using 2 Hz EA for the treatment of opiate addiction. (C) 2009 Elsevier Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000273051700030
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54247
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Peking Univ, Neurosci Res Inst, Beijing, Peoples R China
2.Peking Univ, Dept Neurobiol, Sch Basic Med Sci, Beijing, Peoples R China

Recommended Citation:
Liang, Jing,Ping, Xing-Jie,Li, Yi-Jing,et al. Morphine-induced conditioned place preference in rats is inhibited by electroacupuncture at 2 Hz: Role of enkephalin in the nucleus accumbens[J]. NEUROPHARMACOLOGY,2010,58(1):233-240.
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