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Morphine-induced conditioned place preference in rats is inhibited by electroacupuncture at 2 Hz: Role of enkephalin in the nucleus accumbens
Liang, Jing1,2; Ping, Xing-Jie1,2; Li, Yi-Jing1,2; Ma, Yao-Ying1,2; Wu, Liu-Zhen1,2; Han, Ji-Sheng1,2; Cui, Cai-Lian1,2
关键词Morphine Conditioned Place Preference Nucleus Accumbens Enkephalin Electroacupuncture
刊名NEUROPHARMACOLOGY
2010
DOI10.1016/j.neuropharm.2009.07.007
58期:1页:233-240
收录类别SCI ; ISTP
文章类型Proceedings Paper
WOS标题词Science & Technology
类目[WOS]Neurosciences ; Pharmacology & Pharmacy
研究领域[WOS]Neurosciences & Neurology ; Pharmacology & Pharmacy
关键词[WOS]OPIOID-RECEPTORS ; ENDOGENOUS LIGANDS ; INDUCED CPP ; BRAIN ; KAPPA ; EXPRESSION ; DRUG ; STIMULATION ; MICRODIALYSIS ; REINSTATEMENT
英文摘要

Our previous studies have demonstrated that morphine-induced conditioned place preference (CPP) can be inhibited by 2 Hz electroacupuncture (EA). This inhibition can be blocked by either the opioid receptor antagonist naloxone (i.p.) or lesion in the nucleus accumbens (NAc), providing evidence that endogenous opioid system in the NAc mediates the effects of EA. Here we report that 1) A single session of 2 Hz EA produced a significant increase of the content of enkephalin in the NAc of morphine-induced CPP rats, and this effect was stronger in three consecutive sessions of EA; 2) Intracerebroventricular injection of the mu-opioid receptor antagonist CTAP or delta-opioid receptor antagonist NTI, but not kappa-opioid receptor antagonist nor-BNI, dose-dependently reversed the inhibitory effects of 2 Hz EA on the expression of morphine-induced CPP; 3) Three consecutive sessions of 2 Hz EA up-regulated the mRNA level of preproenkephalin in the NAc of morphine-induced CPP rats. The results suggest that the inhibitory effects of 2 Hz EA on the expression of the morphine CPP is mediated by mu- and delta-, but not kappa-opioid receptor, possibly via accelerating both the release and synthesis of enkephalin in the NAc. These findings support the possibility of using 2 Hz EA for the treatment of opiate addiction. (C) 2009 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000273051700030
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被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54247
专题北京大学基础医学院_神经生物学系
北京大学基础医学院
作者单位1.Peking Univ, Neurosci Res Inst, Beijing, Peoples R China
2.Peking Univ, Dept Neurobiol, Sch Basic Med Sci, Beijing, Peoples R China
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GB/T 7714
Liang, Jing,Ping, Xing-Jie,Li, Yi-Jing,et al. Morphine-induced conditioned place preference in rats is inhibited by electroacupuncture at 2 Hz: Role of enkephalin in the nucleus accumbens[J]. NEUROPHARMACOLOGY,2010,58(1):233-240.
APA Liang, Jing.,Ping, Xing-Jie.,Li, Yi-Jing.,Ma, Yao-Ying.,Wu, Liu-Zhen.,...&Cui, Cai-Lian.(2010).Morphine-induced conditioned place preference in rats is inhibited by electroacupuncture at 2 Hz: Role of enkephalin in the nucleus accumbens.NEUROPHARMACOLOGY,58(1),233-240.
MLA Liang, Jing,et al."Morphine-induced conditioned place preference in rats is inhibited by electroacupuncture at 2 Hz: Role of enkephalin in the nucleus accumbens".NEUROPHARMACOLOGY 58.1(2010):233-240.
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