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Cannabinoid CB(1) receptor antagonist rimonabant attenuates reinstatement of ketamine conditioned place preference in rats
Li, Fangqiong1,2; Fang, Qin1,2; Liu, Yu3; Zhao, Mei3; Li, Dapeng1,2; Wang, Jishi1,2; Lu, Lin3
关键词Cannabinoid Cb(1) Receptor Antagonist Conditioned Place Preference Ketamine Rimonabant Relapse Reinstatement
刊名EUROPEAN JOURNAL OF PHARMACOLOGY
2008-07-28
DOI10.1016/j.ejphar.2008.04.051
589期:1-3页:122-126
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]CANNABINOID CB1 RECEPTORS ; NMDA-ANTAGONISTS ; GLUTAMATERGIC TRANSMISSION ; SYNAPTIC-TRANSMISSION ; NUCLEUS-ACCUMBENS ; DOPAMINE RELEASE ; MEASURING REWARD ; RAPID TOLERANCE ; COCAINE ; ETHANOL
英文摘要

Recent evidence suggests that cannabinoid CB, receptors may represent effective targets for therapeutic agents used to treat cocaine and heroin relapse. However, the role of cannabinoid CB(1) receptors in the potential treatment for other drugs of abuse is still largely unknown. The present study was conducted to determine whether cannabinoid CB(1) receptors play a similar role in relapse to ketamine abuse. To establish a ketamine reinstatement model in the conditioned place preference paradigm, rats were trained to develop place preference conditioned by ketamine, which was subsequently extinguished through daily exposure to the test chambers in the absence of ketamine. On the day following the last extinction session, four groups of rats were injected with ketamine (1, 5, 10 and 15 mg/kg, i.p.) to reinstate previously extinguished conditioned place preference. To investigate the effects of rimonabant, a cannabinoid CB, receptor antagonist, on reinstatement of ketarnine-induced place preference, different doses of rimonabant (0.1, 0.5 and 3 mg/kg. i.p) were injected 30 min prior to the ketamine (5 and 15 mg/kg, i.p.) priming injection in a separate group of rats. To determine whether rimonabant itself produces conditioned place preference or conditioned place aversion, rats were trained for conditioned place preference or place aversion with rimonabant (0, 0.1, 0.5, 3.0 mg/kg, i.p.). While ketamine priming injections reinstated extinguished place preference, rimonabant administration significantly attenuated the reinstatement of ketamine-induced place preference in a closedependent manner. Importantly, rimonabant itself did not produce conditioned place preference or place aversion. Since the reinstatement effects of ketamine administration were inhibited by rimonabant, these findings suggest that a cannabinoid CB, receptor antagonist may be useful in preventing relapse to ketamine abuse. (C) 2008 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000258628400023
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54248
专题中国药物依赖性研究所
作者单位1.Guiyang Med Coll, Sch Pharmacol, Guiyang 550004, Peoples R China
2.Guiyang Med Coll, Affiliated Hosp, Guiyang 550004, Peoples R China
3.Peking Univ, Natl Inst Drug Dependence, Beijing 100082, Peoples R China
推荐引用方式
GB/T 7714
Li, Fangqiong,Fang, Qin,Liu, Yu,et al. Cannabinoid CB(1) receptor antagonist rimonabant attenuates reinstatement of ketamine conditioned place preference in rats[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2008,589(1-3):122-126.
APA Li, Fangqiong.,Fang, Qin.,Liu, Yu.,Zhao, Mei.,Li, Dapeng.,...&Lu, Lin.(2008).Cannabinoid CB(1) receptor antagonist rimonabant attenuates reinstatement of ketamine conditioned place preference in rats.EUROPEAN JOURNAL OF PHARMACOLOGY,589(1-3),122-126.
MLA Li, Fangqiong,et al."Cannabinoid CB(1) receptor antagonist rimonabant attenuates reinstatement of ketamine conditioned place preference in rats".EUROPEAN JOURNAL OF PHARMACOLOGY 589.1-3(2008):122-126.
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