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学科主题: 药物依赖
题名:
Cannabinoid CB(1) receptor antagonist rimonabant attenuates reinstatement of ketamine conditioned place preference in rats
作者: Li, Fangqiong1,2; Fang, Qin1,2; Liu, Yu3; Zhao, Mei3; Li, Dapeng1,2; Wang, Jishi1,2; Lu, Lin3
关键词: cannabinoid CB(1) receptor antagonist ; conditioned place preference ; ketamine ; rimonabant ; relapse ; reinstatement
刊名: EUROPEAN JOURNAL OF PHARMACOLOGY
发表日期: 2008-07-28
DOI: 10.1016/j.ejphar.2008.04.051
卷: 589, 期:1-3, 页:122-126
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: CANNABINOID CB1 RECEPTORS ; NMDA-ANTAGONISTS ; GLUTAMATERGIC TRANSMISSION ; SYNAPTIC-TRANSMISSION ; NUCLEUS-ACCUMBENS ; DOPAMINE RELEASE ; MEASURING REWARD ; RAPID TOLERANCE ; COCAINE ; ETHANOL
英文摘要:

Recent evidence suggests that cannabinoid CB, receptors may represent effective targets for therapeutic agents used to treat cocaine and heroin relapse. However, the role of cannabinoid CB(1) receptors in the potential treatment for other drugs of abuse is still largely unknown. The present study was conducted to determine whether cannabinoid CB(1) receptors play a similar role in relapse to ketamine abuse. To establish a ketamine reinstatement model in the conditioned place preference paradigm, rats were trained to develop place preference conditioned by ketamine, which was subsequently extinguished through daily exposure to the test chambers in the absence of ketamine. On the day following the last extinction session, four groups of rats were injected with ketamine (1, 5, 10 and 15 mg/kg, i.p.) to reinstate previously extinguished conditioned place preference. To investigate the effects of rimonabant, a cannabinoid CB, receptor antagonist, on reinstatement of ketarnine-induced place preference, different doses of rimonabant (0.1, 0.5 and 3 mg/kg. i.p) were injected 30 min prior to the ketamine (5 and 15 mg/kg, i.p.) priming injection in a separate group of rats. To determine whether rimonabant itself produces conditioned place preference or conditioned place aversion, rats were trained for conditioned place preference or place aversion with rimonabant (0, 0.1, 0.5, 3.0 mg/kg, i.p.). While ketamine priming injections reinstated extinguished place preference, rimonabant administration significantly attenuated the reinstatement of ketamine-induced place preference in a closedependent manner. Importantly, rimonabant itself did not produce conditioned place preference or place aversion. Since the reinstatement effects of ketamine administration were inhibited by rimonabant, these findings suggest that a cannabinoid CB, receptor antagonist may be useful in preventing relapse to ketamine abuse. (C) 2008 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000258628400023
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54248
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Guiyang Med Coll, Sch Pharmacol, Guiyang 550004, Peoples R China
2.Guiyang Med Coll, Affiliated Hosp, Guiyang 550004, Peoples R China
3.Peking Univ, Natl Inst Drug Dependence, Beijing 100082, Peoples R China

Recommended Citation:
Li, Fangqiong,Fang, Qin,Liu, Yu,et al. Cannabinoid CB(1) receptor antagonist rimonabant attenuates reinstatement of ketamine conditioned place preference in rats[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2008,589(1-3):122-126.
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