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学科主题临床医学
Contralateral upper tract urothelial carcinoma after nephroureterectomy: the predictive role of DNA methylation
Zhang, Lei1; Xiong, Gengyan1; Fang, Dong1; Li, Xuesong1; Liu, Jin1; Ci, Weimin2; Zhao, Wei3; Singla, Nirmish4; He, Zhisong1; Zhou, Liqun1
关键词Methylation Upper Tract Urothelial Carcinoma Contralateral Recurrence Radical Nephroureterectomy Predictors
刊名JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
2015-01-22
DOI10.1186/s13046-015-0120-2
34
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
资助者Collaborative Research Foundation of Peking University Health Science Center ; College of Medicine ; Natural Science Foundation of Beijing ; Natural Science Foundation of China ; Research Foundation of Peking University First Hospital ; National Taiwan University ; Collaborative Research Foundation of Peking University Health Science Center ; College of Medicine ; Natural Science Foundation of Beijing ; Natural Science Foundation of China ; Research Foundation of Peking University First Hospital ; National Taiwan University
研究领域[WOS]Oncology
关键词[WOS]UPPER URINARY-TRACT ; TRANSITIONAL-CELL-CARCINOMA ; INVASIVE BLADDER-CANCER ; PROMOTER HYPERMETHYLATION ; RENAL PELVIS ; TUMORS ; NEPHROPATHY ; ASSOCIATION ; EXPRESSION ; PROGNOSIS
英文摘要

Background: Aberrant methylation of genes is one of the most common epigenetic modifications involved in the development of urothelial carcinoma. However, it is unknown the predictive role of methylation to contralateral new upper tract urothelial carcinoma (UTUC) after radical nephroureterectomy (RNU). We retrospectively investigated the predictive role of DNA methylation and other clinicopathological factors in the contralateral upper tract urothelial carcinoma (UTUC) recurrence after radical nephroureterectomy (RNU) in a large single-center cohort of patients.

Methods: In a retrospective design, methylation of 10 genes was analyzed on tumor specimens belonging to 664 consecutive patients treated by RNU for primary UTUC. Median follow-up was 48 mo (range: 3-144 mo). Gene methylation was accessed by methylation-sensitive polymerase chain reaction, and we calculated the methylation index (MI), a reflection of the extent of methylation. The log-rank test and Cox regression were used to identify the predictor of contralateral UTUC recurrence.

Results: Thirty (4.5%) patients developed a subsequent contralateral UTUC after a median follow-up time of 27.5 (range: 2-139) months. Promoter methylation for at least one gene promoter locus was present in 88.9% of UTUC. Fewer methylation and lower MI (P = 0.001) were seen in the tumors with contralateral UTUC recurrence than the tumors without contralateral recurrence. High MI (P = 0.007) was significantly correlated with poor cancer-specific survival. Multivariate analysis indicated that unmethylated RASSF1A (P = 0.039), lack of bladder recurrence prior to contralateral UTUC (P = 0.009), history of renal transplantation (P < 0.001), and preoperative renal insufficiency (P = 0.002) are independent risk factors for contralateral UTUC recurrence after RNU.

Conclusions: Our data suggest a potential role of DNA methylation in predicting contralateral UTUC recurrence after RNU. Such information could help identify patients at high risk of new contralateral UTUC recurrence after RNU who need close surveillance during follow up.

语种英语
所属项目编号BMU20120318 ; 7122183 ; 81172419 ; 81372746
资助者Collaborative Research Foundation of Peking University Health Science Center ; College of Medicine ; Natural Science Foundation of Beijing ; Natural Science Foundation of China ; Research Foundation of Peking University First Hospital ; National Taiwan University ; Collaborative Research Foundation of Peking University Health Science Center ; College of Medicine ; Natural Science Foundation of Beijing ; Natural Science Foundation of China ; Research Foundation of Peking University First Hospital ; National Taiwan University
WOS记录号WOS:000349130400001
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54249
Collection北京大学第一临床医学院_泌尿外科
作者单位1.Peking Univ, Hosp 1, Inst Urol, Natl Urol Canc Ctr,Dept Urol, Beijing 100034, Peoples R China
2.Chinese Acad Sci, Beijing Inst Genom, Beijing 100101, Peoples R China
3.Peking Univ, Canc Hosp & Inst, Minist Educ, Dept Cell Biol,Key Lab Carcinogenesis & Translat, Beijing 100142, Peoples R China
4.Univ Texas SW Med Ctr Dallas, Dept Urol, Dallas, TX 75390 USA
Recommended Citation
GB/T 7714
Zhang, Lei,Xiong, Gengyan,Fang, Dong,et al. Contralateral upper tract urothelial carcinoma after nephroureterectomy: the predictive role of DNA methylation[J]. JOURNAL OF EXPERIMENTAL &amp; CLINICAL CANCER RESEARCH,2015,34.
APA Zhang, Lei.,Xiong, Gengyan.,Fang, Dong.,Li, Xuesong.,Liu, Jin.,...&Zhou, Liqun.(2015).Contralateral upper tract urothelial carcinoma after nephroureterectomy: the predictive role of DNA methylation.JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH,34.
MLA Zhang, Lei,et al."Contralateral upper tract urothelial carcinoma after nephroureterectomy: the predictive role of DNA methylation".JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 34(2015).
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