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学科主题: 临床医学
题名:
Antioxidant icariside II combined with insulin restores erectile function in streptozotocin-induced type 1 diabetic rats
作者: Wang, Lin; Xu, Yongde; Li, Huixi; Lei, Hongen; Guan, Ruili; Gao, Zhezhu; Xin, Zhongcheng
关键词: diabetes mellitus ; erectile dysfunction ; icariside II ; metabolic memory
刊名: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
发表日期: 2015-05-01
DOI: 10.1111/jcmm.12480
卷: 19, 期:5, 页:960-969
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Medicine, Research & Experimental
研究领域[WOS]: Cell Biology ; Research & Experimental Medicine
关键词[WOS]: GLYCATION END-PRODUCTS ; OXIDATIVE STRESS ; GLYCEMIC CONTROL ; GLUCOSE CONTROL ; RISK-FACTORS ; DYSFUNCTION ; COMPLICATIONS ; PEROXIDATION ; RECEPTOR ; THERAPY
英文摘要:

Erectile dysfunction (ED) worsens in patients with diabetes mellitus (DM) despite good control of blood glucose level with insulin. Recent studies imply that diabetic vascular stresses (e.g. oxidative stress) persist in spite of glucose normalization, which is defined as metabolic memory. Studies suggest that the interaction between advanced glycation end products (AGEs) and their receptor (RAGE) mediates the development of metabolic memory. To investigate the effects of the antioxidant icariside II plus insulin on erectile function in streptozotocin (STZ)- induced type 1 diabetic rats. Fifty 8-week-old Sprague-Dawley rats were randomly distributed into five groups: normal control, diabetic, insulin-treated diabetic, icariside II-treated diabetic, and insulin plus icariside II-treated diabetic. Diabetes was induced by a single intraperitoneal injection of STZ. Eight weeks after induction of diabetes, icariside II was administered by gastric lavage once a day (5mg/kg) for 6weeks; and 2-6 units of intermediate-acting insulin were given to maintain normal glycemia for 6weeks. The main outcome measures were the ratio of intracavernous pressure (ICP) to mean arterial pressure (MAP); histology of penile endothelial cells and smooth muscle cells; neural nitric oxide synthase, AGEs and RAGE expression; malondialdehyde concentration; superoxide dismutase activity; and apoptosis index. Diabetic rats demonstrated a significantly lower ICP/MAP ratio, reduced penile endothelial cells, reduced smooth muscle cells, increased AGEs and RAGE, and increased apoptosis. Insulin and icariside II monotherapy partially restored erectile function and histological changes. However, the combination therapy group showed significantly better erectile parameters, cytological components and biochemistry, similar to those in the normal control group. These results suggest that, although insulin can effectively control glycemic levels, it does not completely alter the pathological changes in erectile tissues. Better efficacy could be expected with tight glycemic control plus the antioxidant icariside II. The proposed combination therapy might have the potential to eliminate metabolic memory by down-regulating the AGEs-RAGE-oxidative stress axis.

语种: 英语
所属项目编号: 81270693 ; 81272531 ; 20120001110021
项目资助者: National Natural Science Foundation of China ; Specialized Research Fund for the Doctoral Program of Higher Education of China
WOS记录号: WOS:000353991100006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54256
Appears in Collections:北京大学第一临床医学院_男科中心_期刊论文

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作者单位: Peking Univ, Hosp 1, Androl Ctr, Beijing 100034, Peoples R China

Recommended Citation:
Wang, Lin,Xu, Yongde,Li, Huixi,et al. Antioxidant icariside II combined with insulin restores erectile function in streptozotocin-induced type 1 diabetic rats[J]. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,2015,19(5):960-969.
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