IR@PKUHSC  > 北京大学第一临床医学院  > 男科中心
学科主题临床医学
Antioxidant icariside II combined with insulin restores erectile function in streptozotocin-induced type 1 diabetic rats
Wang, Lin; Xu, Yongde; Li, Huixi; Lei, Hongen; Guan, Ruili; Gao, Zhezhu; Xin, Zhongcheng
关键词Diabetes Mellitus Erectile Dysfunction Icariside Ii Metabolic Memory
刊名JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
2015-05-01
DOI10.1111/jcmm.12480
19期:5页:960-969
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Medicine, Research & Experimental
资助者National Natural Science Foundation of China ; Specialized Research Fund for the Doctoral Program of Higher Education of China ; National Natural Science Foundation of China ; Specialized Research Fund for the Doctoral Program of Higher Education of China
研究领域[WOS]Cell Biology ; Research & Experimental Medicine
关键词[WOS]GLYCATION END-PRODUCTS ; OXIDATIVE STRESS ; GLYCEMIC CONTROL ; GLUCOSE CONTROL ; RISK-FACTORS ; DYSFUNCTION ; COMPLICATIONS ; PEROXIDATION ; RECEPTOR ; THERAPY
英文摘要

Erectile dysfunction (ED) worsens in patients with diabetes mellitus (DM) despite good control of blood glucose level with insulin. Recent studies imply that diabetic vascular stresses (e.g. oxidative stress) persist in spite of glucose normalization, which is defined as metabolic memory. Studies suggest that the interaction between advanced glycation end products (AGEs) and their receptor (RAGE) mediates the development of metabolic memory. To investigate the effects of the antioxidant icariside II plus insulin on erectile function in streptozotocin (STZ)- induced type 1 diabetic rats. Fifty 8-week-old Sprague-Dawley rats were randomly distributed into five groups: normal control, diabetic, insulin-treated diabetic, icariside II-treated diabetic, and insulin plus icariside II-treated diabetic. Diabetes was induced by a single intraperitoneal injection of STZ. Eight weeks after induction of diabetes, icariside II was administered by gastric lavage once a day (5mg/kg) for 6weeks; and 2-6 units of intermediate-acting insulin were given to maintain normal glycemia for 6weeks. The main outcome measures were the ratio of intracavernous pressure (ICP) to mean arterial pressure (MAP); histology of penile endothelial cells and smooth muscle cells; neural nitric oxide synthase, AGEs and RAGE expression; malondialdehyde concentration; superoxide dismutase activity; and apoptosis index. Diabetic rats demonstrated a significantly lower ICP/MAP ratio, reduced penile endothelial cells, reduced smooth muscle cells, increased AGEs and RAGE, and increased apoptosis. Insulin and icariside II monotherapy partially restored erectile function and histological changes. However, the combination therapy group showed significantly better erectile parameters, cytological components and biochemistry, similar to those in the normal control group. These results suggest that, although insulin can effectively control glycemic levels, it does not completely alter the pathological changes in erectile tissues. Better efficacy could be expected with tight glycemic control plus the antioxidant icariside II. The proposed combination therapy might have the potential to eliminate metabolic memory by down-regulating the AGEs-RAGE-oxidative stress axis.

语种英语
所属项目编号81270693 ; 81272531 ; 20120001110021
资助者National Natural Science Foundation of China ; Specialized Research Fund for the Doctoral Program of Higher Education of China ; National Natural Science Foundation of China ; Specialized Research Fund for the Doctoral Program of Higher Education of China
WOS记录号WOS:000353991100006
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54256
专题北京大学第一临床医学院_男科中心
作者单位Peking Univ, Hosp 1, Androl Ctr, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Wang, Lin,Xu, Yongde,Li, Huixi,et al. Antioxidant icariside II combined with insulin restores erectile function in streptozotocin-induced type 1 diabetic rats[J]. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,2015,19(5):960-969.
APA Wang, Lin.,Xu, Yongde.,Li, Huixi.,Lei, Hongen.,Guan, Ruili.,...&Xin, Zhongcheng.(2015).Antioxidant icariside II combined with insulin restores erectile function in streptozotocin-induced type 1 diabetic rats.JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,19(5),960-969.
MLA Wang, Lin,et al."Antioxidant icariside II combined with insulin restores erectile function in streptozotocin-induced type 1 diabetic rats".JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 19.5(2015):960-969.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wang, Lin]的文章
[Xu, Yongde]的文章
[Li, Huixi]的文章
百度学术
百度学术中相似的文章
[Wang, Lin]的文章
[Xu, Yongde]的文章
[Li, Huixi]的文章
必应学术
必应学术中相似的文章
[Wang, Lin]的文章
[Xu, Yongde]的文章
[Li, Huixi]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。