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学科主题临床医学
Microfluidic synthesis of ultra-small magnetic nanohybrids for enhanced magnetic resonance imaging
Wang, Junmei1; Zhao, Kai2; Shen, Xiaomiao1; Zhang, Weiwei1; Ji, Shaoxia1; Song, Yujun1; Zhang, Xiaodong2; Rong, Rong2; Wang, Xiaoying2
刊名JOURNAL OF MATERIALS CHEMISTRY C
2015
DOI10.1039/c5tc02279g
3期:48页:12418-12429
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Materials Science, Multidisciplinary ; Physics, Applied
研究领域[WOS]Materials Science ; Physics
关键词[WOS]CORE-SHELL NANOPARTICLES ; COBALT NANOPARTICLES ; CONTRAST ENHANCEMENT ; SCALE SYNTHESIS ; OXIDE ; NANOSTRUCTURES ; NANOCRYSTALS ; AGENTS ; FILM ; NANOSPHERES
英文摘要

We have developed a core alloying and shell gradient doping strategy for the controlled surface modification of nanoparticles, realized by a coupled competitive reducing-nucleation and precipitation reaction controlled in microfluidic channels. Here it is extended in surface modification of Fe and CoFe nanoparticles by doping zinc oxide and aluminum oxide to form well-dispersed stable ultra-small Fe(1-x)Znx@Zn(1-y)FeyO-(OH)(z) and (CoFe)((1-x))Al-x@Al(1-y)(CoFe)(y)O-(OH)(z) nanohybrids as contrast agents for magnetic resonance imaging (MRI). They exhibit greatly enhanced T-1 weighted spin echo imaging and T-2 weighted spin echo imaging effects. Particularly, (CoFe)((1-x))Al-x@Al(1-y)(CoFe)(y)O-(OH)(z) nanohybrids give a T-1 relaxation rate (R-1) of 0.156 (mu g-CoFe mL(-1))(-1) s(-1) and a T-2 relaxation rate (R-2) of 0.486 (mu g-CoFe mL(-1))(-1) s(-1), much higher than the commercial gadopentetate dimeglumine (R-1 = 0.022 (mu g-Gd mL(-1))(-1) s(-1); R-2 = 0.025 (mu g-Gd mL(-1))(-1) s(-1)). The R-1 of (CoFe)((1-x))Al-x@Al(1-y)(CoFe)(y)O-(OH)(z) nanohybrids is also higher than superparamagnetic iron oxide (SPIO) nanoparticles (R-1 = 0.121 (mu g-Fe mL(-1))(-1) s(-1)). SPIO nanoparticles of 7.1 +/- 1.2 nm still show an excellent negative MRI contrast agent by the highest R-2 (5.07 (mu g-Fe mL(-1))(-1) s(-1)) and R-2/R-1 ratio (42) among these reagents.

语种英语
WOS记录号WOS:000366413600010
项目编号51371018 ; 50971010 ; FRF-BR-14-001B
资助机构NSFC ; Fundamental Research Funds for the Central Universities
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54267
专题北京大学第一临床医学院_放射治疗科
北京大学第一临床医学院_医学影像科
北京大学临床肿瘤学院_消化肿瘤内科
作者单位1.Univ Sci & Technol Beijing, Sch Math & Phys, Engn Ctr Weak Magnet Detect Beijing, Dept Phys,Ctr Modern Phys, Beijing 100083, Peoples R China
2.Peking Univ, Hosp 1, Dept Radiol, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Wang, Junmei,Zhao, Kai,Shen, Xiaomiao,et al. Microfluidic synthesis of ultra-small magnetic nanohybrids for enhanced magnetic resonance imaging[J]. JOURNAL OF MATERIALS CHEMISTRY C,2015,3(48):12418-12429.
APA Wang, Junmei.,Zhao, Kai.,Shen, Xiaomiao.,Zhang, Weiwei.,Ji, Shaoxia.,...&Wang, Xiaoying.(2015).Microfluidic synthesis of ultra-small magnetic nanohybrids for enhanced magnetic resonance imaging.JOURNAL OF MATERIALS CHEMISTRY C,3(48),12418-12429.
MLA Wang, Junmei,et al."Microfluidic synthesis of ultra-small magnetic nanohybrids for enhanced magnetic resonance imaging".JOURNAL OF MATERIALS CHEMISTRY C 3.48(2015):12418-12429.
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