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学科主题: 临床医学
题名:
A Classification of Hashimoto′s Thyroiditis Based on Immunohistochemistry for IgG4 and IgG
作者: Zhang, Jing1; Zhao, Lanlan1; Gao, Ying1; Liu, Mingming1; Li, Ting2; Huang, Youyuan1; Lu, Guizhi1; Gao, Yanming1; Guo, Xiaohui1; Shi, Bingyin3
刊名: THYROID
发表日期: 2014-02-01
DOI: 10.1089/thy.2013.0211
卷: 24, 期:2, 页:364-370
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: IGG4-RELATED DISEASE ; FUNCTIONAL STATUS ; PLASMA-CELLS ; ANTIBODY ; FEATURES ; RESPECT ; VARIANT ; SERA
英文摘要:

Background: Hashimoto′s thyroiditis (HT) is a common organ-specific autoimmune disease. Antithyroglobulin antibodies (TgAb) and antithyroperoxidase antibodies (TPOAb), predominantly of the immunoglobulin (Ig) G class, are hallmarks of HT. It has been reported that HT can be divided into IgG4 and non-IgG4 thyroiditis. The aim of our study was to investigate the meaning of this classification. Methods: Thyroid sections from 53 Hashimoto′s patients with stored serum samples were collected to detect IgG4, IgG, -smooth muscle actin, and transforming growth factor-1 expression by immunohistochemical staining. The degree of fibrosis of thyroid parenchyma was qualitatively evaluated by Masson′s trichrome. Serum total IgG, IgG4, TPOAb IgG, TgAb IgG, TPOAb IgG4, and TgAb IgG4 were detected by enzyme-linked immunosorbent assays (ELISAs). Results: Based on immunohistochemistry for IgG4 and IgG, 12 cases of IgG4-positive HT and 41 cases of IgG4-negative HT were identified in our study. The patients in the IgG4-positive HT group were significantly younger than those in the IgG4-negative HT group (p=0.023), and no significant differences were found in sex distribution, disease duration, and distribution of thyroid functional status between these two groups. The degree of fibrosis evaluated by Masson′s trichrome and the immunohistochemical expression score of TGF-1 in the IgG4-positive HT were significantly higher than those in the IgG4-negative HT (p<0.05). No significant differences were found in the levels of serum IgG4, total IgG, or IgG4/IgG ratio. However, TPOAb IgG4 and TgAb IgG4 levels and the ratios of TPOAb IgG4/TPOAb IgG, TgAb IgG4/TgAb IgG, TPOAb IgG4/IgG4, and TgAb IgG4/IgG4 were significantly higher in the IgG4-positive HT group than those in the IgG4-negative HT group respectively (p<0.05). Conclusions: Our study indicates that HT can be divided into IgG4-positive and IgG4-negative HT, and this classification might have important clinical implications. The levels of IgG4 binding to specific thyroid antigens might be noninvasive markers to differentiate these two different immunophenotypes.

语种: 英语
所属项目编号: 2011011 ; NCET-11-0003 ; 201002002
项目资助者: Beijing Nova Program ; Program for New Century Excellent Talents in University ; Ministry of Health
WOS记录号: WOS:000331245300023
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54270
Appears in Collections:北京大学第一临床医学院_内分泌内科_期刊论文

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作者单位: 1.Peking Univ, Dept Endocrinol, Hosp 1, Beijing 100034, Peoples R China
2.Peking Univ, Dept Pathol, Hosp 1, Beijing 100034, Peoples R China
3.Xi An Jiao Tong Univ, Sch Med, Affiliated Hosp 1, Dept Endocrinol, Xian 710049, Peoples R China

Recommended Citation:
Zhang, Jing,Zhao, Lanlan,Gao, Ying,et al. A Classification of Hashimoto&prime;s Thyroiditis Based on Immunohistochemistry for IgG4 and IgG[J]. THYROID,2014,24(2):364-370.
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