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学科主题: 临床医学
题名:
Phospholipase A2 group IIA expression in gastric adenocarcinoma is associated with prolonged survival and less frequent metastasis
作者: Leung, SY; Chen, X; Chu, KM; Yuen, ST; Mathy, J; Ji, JF; Chan, ASY; Li, R; Law, S; Troyanskaya, OG; Tu, IP; Wong, J; So, S; Botstein, D; Brown, PO
关键词: gene expression profiling ; DNA microarray ; mucosal immunity ; gastritis ; Helicobacter
刊名: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
发表日期: 2002-12-10
DOI: 10.1073/pnas.212646299
卷: 99, 期:25, 页:16203-16208
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: INTESTINAL NEOPLASIA ; MAJOR MODIFIER ; A(2) ; GENE ; TUMORIGENESIS ; APOPTOSIS ; MORTALITY ; INFECTION ; PLASMA ; LOCUS
英文摘要:

We analyzed gene expression patterns in human gastric cancers by using cDNA microarrays representing approximate to30,300 genes. Expression of PLA2G2A, a gene previously implicated as a modifier of the Apc(Min/+) (multiple intestinal neoplasia 1) mutant phenotype in the mouse, was significantly correlated with patient survival. We confirmed this observation in an independent set of patient samples by using quantitative RT-PCR. Beyond its potential diagnostic and prognostic significance, this result suggests the intriguing possibility that the activity of PLA2G2A may suppress progression or metastasis of human gastric cancer.

语种: 英语
WOS记录号: WOS:000179783400069
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54271
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Stanford Univ, Sch Med, Dept Genet, Stanford, CA 94305 USA
2.Stanford Univ, Sch Med, Asian Liver Ctr, Stanford, CA 94305 USA
3.Stanford Univ, Sch Med, Dept Surg, Stanford, CA 94305 USA
4.Stanford Univ, Sch Med, Dept Biochem, Stanford, CA 94305 USA
5.Stanford Univ, Sch Med, Howard Hughes Med Inst, Stanford, CA 94305 USA
6.Univ Hong Kong, Dept Pathol, Hong Kong, Hong Kong, Peoples R China
7.Univ Hong Kong, Dept Surg, Hong Kong, Hong Kong, Peoples R China
8.Peking Univ, Sch Oncol, Beijing Canc Hosp, Dept Surg, Beijing 100036, Peoples R China

Recommended Citation:
Leung, SY,Chen, X,Chu, KM,et al. Phospholipase A2 group IIA expression in gastric adenocarcinoma is associated with prolonged survival and less frequent metastasis[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2002,99(25):16203-16208.
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