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Mulberroside F isolated from the leaves of Morus alba inhibits melanin biosynthesis
Lee, SH; Choi, SY; Kim, H; Hwang, JS; Lee, BG; Gao, JJ; Kim, SY
关键词Morus Alba Moraceae Mulberroside f Whitening Agent
刊名BIOLOGICAL & PHARMACEUTICAL BULLETIN
2002-08-01
25期:8页:1045-1048
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]HYPOGLYCEMIC ACTIVITY ; PIGMENTATION ; TYROSINASE ; SUGARS
英文摘要

The current study was carried out to investigate the in vitro effects of an 85% methanol extract of dried Morus alba leaves on melanin biosynthesis, which is closely related to hyperpigmentation. These extracts inhibited the tyrosinase activity that converts dopa to dopachrome in the biosynthetic process of melanin. Mulberroside F (moracin M-6, 3′-di-O-beta-D-glucopyranoside), which was obtained after the bioactivity-guided fractionation of the extracts, showed inhibitory effects on tyrosinase activity and on the melanin formation of melan-a cells. This compound also exhibited superoxide scavenging activity that is involved in the protection against autooxidation. But its activity was low and was weaker than of kojic acid. These results suggest that mulberroside F isolated from mulberry leaves might be used as a skin whitening agent.

语种英语
WOS记录号WOS:000177198000020
引用统计
被引频次:89[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54273
专题北京大学药学院
作者单位1.Pacfici R&D, Skin Res Inst, Kyoungi Do, South Korea
2.Kyung Hee Univ, Grad Sch East West Med Sci, Dept Herbal Pharmacol, Seoul 130701, South Korea
3.Beijing Med Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
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GB/T 7714
Lee, SH,Choi, SY,Kim, H,et al. Mulberroside F isolated from the leaves of Morus alba inhibits melanin biosynthesis[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2002,25(8):1045-1048.
APA Lee, SH.,Choi, SY.,Kim, H.,Hwang, JS.,Lee, BG.,...&Kim, SY.(2002).Mulberroside F isolated from the leaves of Morus alba inhibits melanin biosynthesis.BIOLOGICAL & PHARMACEUTICAL BULLETIN,25(8),1045-1048.
MLA Lee, SH,et al."Mulberroside F isolated from the leaves of Morus alba inhibits melanin biosynthesis".BIOLOGICAL & PHARMACEUTICAL BULLETIN 25.8(2002):1045-1048.
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