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学科主题: 药学
题名:
Mulberroside F isolated from the leaves of Morus alba inhibits melanin biosynthesis
作者: Lee, SH; Choi, SY; Kim, H; Hwang, JS; Lee, BG; Gao, JJ; Kim, SY
关键词: Morus alba ; Moraceae ; mulberroside F ; whitening agent
刊名: BIOLOGICAL & PHARMACEUTICAL BULLETIN
发表日期: 2002-08-01
卷: 25, 期:8, 页:1045-1048
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: HYPOGLYCEMIC ACTIVITY ; PIGMENTATION ; TYROSINASE ; SUGARS
英文摘要:

The current study was carried out to investigate the in vitro effects of an 85% methanol extract of dried Morus alba leaves on melanin biosynthesis, which is closely related to hyperpigmentation. These extracts inhibited the tyrosinase activity that converts dopa to dopachrome in the biosynthetic process of melanin. Mulberroside F (moracin M-6, 3′-di-O-beta-D-glucopyranoside), which was obtained after the bioactivity-guided fractionation of the extracts, showed inhibitory effects on tyrosinase activity and on the melanin formation of melan-a cells. This compound also exhibited superoxide scavenging activity that is involved in the protection against autooxidation. But its activity was low and was weaker than of kojic acid. These results suggest that mulberroside F isolated from mulberry leaves might be used as a skin whitening agent.

语种: 英语
WOS记录号: WOS:000177198000020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54273
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Pacfici R&D, Skin Res Inst, Kyoungi Do, South Korea
2.Kyung Hee Univ, Grad Sch East West Med Sci, Dept Herbal Pharmacol, Seoul 130701, South Korea
3.Beijing Med Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China

Recommended Citation:
Lee, SH,Choi, SY,Kim, H,et al. Mulberroside F isolated from the leaves of Morus alba inhibits melanin biosynthesis[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2002,25(8):1045-1048.
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