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学科主题: 临床医学
题名:
In vitro susceptibility testing of amorolfine in pathogenic fungi isolated from dermatomycosis patients in China
作者: Li, RY; Wan, Z; Wang, AP; Shen, YN; Lu, CM; Li, M; Xi, LY; Liu, WD; Zeng, FQ
关键词: dermatophytes ; yeasts ; molds ; antifungal susceptibility ; amorolfine
刊名: MYCOSES
发表日期: 2004-10-01
卷: 47, 期:9-10, 页:402-406
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dermatology ; Mycology
研究领域[WOS]: Dermatology ; Mycology
英文摘要:

The antifungal susceptibility of isolates from Chinese dermatomycosis patients to amorolfine was investigated following National Committee for Clinical Laboratory Standards (NCCLS) protocols. In total, 383 isolates were tested, including 132 strains from tinea pedis, 148 strains from tinea corporis/cruris, and 103 strains from onychomycosis. The minimum inhibitory concentration (MIC) of amorolfine against dermatophytes ranged from 0.01 to 0.08 mug ml(-1). The MIC50 and MIC90 of amorolfine for Trichophyton rubrum were both equal to 0.04 mug ml(-1); for T. mentagrophytes these MICs were 0.04 mug ml(-1) and 0.08 mug ml(-1) respectively; and for Epidermophyton floccosum they were 0.02 mug ml(-1) and 0.04 mug ml(-1) respectively. The MIC range of amorolfine against Candida parapsilosis was 0.5-16 mug ml(-1). MIC50 and MIC90 for C. parapsilosis were 0.5 and 2 mug ml(-1). MIC ranges of amorolfine against Scopulariopsis spp. and Acremonium spp. were 0.5-4 and 2-8 mug ml(-1), respectively. Candida albicans, Fusarium solani and Aspergillus flavus required relatively higher concentrations of amorolfine to inhibit their growth (MIC 0.125-64 mug ml(-1), MIC50 and MIC90 were 4 and 64 mug ml(-1)). The results demonstrated that amorolfine is the only topical agent that has such a potent antifungal activity and a broad spectrum against a wide range of pathogenic fungi.

语种: 英语
WOS记录号: WOS:000224645400003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54281
Appears in Collections:北京大学第一临床医学院_皮肤性病科_期刊论文

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作者单位: 1.Peking Univ, Res Ctr Med Mycol, Hosp 1, Dept Dermatol, Beijing 100034, Peoples R China
2.Chinese Acad Med, Inst Dermatol, Nanjing, Peoples R China
3.Zhongshan Univ, Hosp 2, Dept Dermatol, Guangzhou, Peoples R China

Recommended Citation:
Li, RY,Wan, Z,Wang, AP,et al. In vitro susceptibility testing of amorolfine in pathogenic fungi isolated from dermatomycosis patients in China[J]. MYCOSES,2004,47(9-10):402-406.
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