IR@PKUHSC  > 北京大学第一临床医学院  > 皮肤性病科
学科主题临床医学
In vitro susceptibility testing of amorolfine in pathogenic fungi isolated from dermatomycosis patients in China
Li, RY; Wan, Z; Wang, AP; Shen, YN; Lu, CM; Li, M; Xi, LY; Liu, WD; Zeng, FQ
关键词Dermatophytes Yeasts Molds Antifungal Susceptibility Amorolfine
刊名MYCOSES
2004-10-01
47期:9-10页:402-406
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dermatology ; Mycology
研究领域[WOS]Dermatology ; Mycology
英文摘要

The antifungal susceptibility of isolates from Chinese dermatomycosis patients to amorolfine was investigated following National Committee for Clinical Laboratory Standards (NCCLS) protocols. In total, 383 isolates were tested, including 132 strains from tinea pedis, 148 strains from tinea corporis/cruris, and 103 strains from onychomycosis. The minimum inhibitory concentration (MIC) of amorolfine against dermatophytes ranged from 0.01 to 0.08 mug ml(-1). The MIC50 and MIC90 of amorolfine for Trichophyton rubrum were both equal to 0.04 mug ml(-1); for T. mentagrophytes these MICs were 0.04 mug ml(-1) and 0.08 mug ml(-1) respectively; and for Epidermophyton floccosum they were 0.02 mug ml(-1) and 0.04 mug ml(-1) respectively. The MIC range of amorolfine against Candida parapsilosis was 0.5-16 mug ml(-1). MIC50 and MIC90 for C. parapsilosis were 0.5 and 2 mug ml(-1). MIC ranges of amorolfine against Scopulariopsis spp. and Acremonium spp. were 0.5-4 and 2-8 mug ml(-1), respectively. Candida albicans, Fusarium solani and Aspergillus flavus required relatively higher concentrations of amorolfine to inhibit their growth (MIC 0.125-64 mug ml(-1), MIC50 and MIC90 were 4 and 64 mug ml(-1)). The results demonstrated that amorolfine is the only topical agent that has such a potent antifungal activity and a broad spectrum against a wide range of pathogenic fungi.

语种英语
WOS记录号WOS:000224645400003
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54281
专题北京大学第一临床医学院_皮肤性病科
作者单位1.Peking Univ, Res Ctr Med Mycol, Hosp 1, Dept Dermatol, Beijing 100034, Peoples R China
2.Chinese Acad Med, Inst Dermatol, Nanjing, Peoples R China
3.Zhongshan Univ, Hosp 2, Dept Dermatol, Guangzhou, Peoples R China
推荐引用方式
GB/T 7714
Li, RY,Wan, Z,Wang, AP,et al. In vitro susceptibility testing of amorolfine in pathogenic fungi isolated from dermatomycosis patients in China[J]. MYCOSES,2004,47(9-10):402-406.
APA Li, RY.,Wan, Z.,Wang, AP.,Shen, YN.,Lu, CM.,...&Zeng, FQ.(2004).In vitro susceptibility testing of amorolfine in pathogenic fungi isolated from dermatomycosis patients in China.MYCOSES,47(9-10),402-406.
MLA Li, RY,et al."In vitro susceptibility testing of amorolfine in pathogenic fungi isolated from dermatomycosis patients in China".MYCOSES 47.9-10(2004):402-406.
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