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Immune reconstitution to cytomegalovirus following partially matched-related donor transplantation: impact of in vivo T-cell depletion and granulocyte colony-stimulating factor-primed peripheral blood/bone marrow mixed grafts
Luo, X. -H.; Huang, X. -J.; Li, D.; Liu, K. -Y.; Xu, L. -P.; Liu, D. -H.
关键词Hematopoietic Stem Cell Transplantation Partially Matched Cytomegalovirus Infection Immune Reconstitution Antigen-specific t Cell
刊名TRANSPLANT INFECTIOUS DISEASE
2013-02-01
DOI10.1111/j.1399-3062.2012.00722.x
15期:1页:22-33
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology ; Infectious Diseases ; Transplantation
研究领域[WOS]Immunology ; Infectious Diseases ; Transplantation
关键词[WOS]IDENTICAL SIBLING TRANSPLANTATION ; INTENSITY CONDITIONING REGIMEN ; VERSUS-HOST-DISEASE ; BONE-MARROW ; ANTITHYMOCYTE GLOBULIN ; HEMATOLOGICAL MALIGNANCIES ; PREEMPTIVE THERAPY ; RECIPIENTS ; INFECTION ; CMV
英文摘要

Cytomegalovirus (CMV) infection and delayed immune reconstitution remains a serious obstacle for successful partially matched-related donor transplantation (PMRD). We evaluated 42 patients for the development of CMV-specific CD8+ T lymphocytes (CTLCMV) following granulocyte colony-stimulating factor-primed peripheral blood (PB) and bone marrow (BM) with anti-thymocyte globulin (ATG)-based PMRD. PMRD recipients achieved a high frequency, proliferation capacity, and interferon-gamma response of CTLCMV at 1 year post transplantation. CTLCMV with the central memory CD45RO+CD62L+ cell phenotype expanded in PB and BM-resident CTLCMV displayed distinct phenotypes when CMV was reactivated. Although the incidence of CMV reactivation was high in PMRD patients (87.67%), only 11.90% of them developed CMV disease. In conclusion, after PMRD using mixed grafts with ATG-based conditioning, immune recovery to CMV seems to be early and fast, thereby reducing the incidence of CMV disease.

语种英语
WOS记录号WOS:000314651600014
项目编号30725038 ; IRT 0702
资助机构National Outstanding Young Scientist&prime ; s Foundation of China ; Program for Innovative Research Team in University ; Ministry of Health of China for Huang Xiao-Jun
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54282
专题北京大学第二临床医学院_血液科
作者单位Peking Univ, Inst Hematol, Peoples Hosp, Beijing 100044, Peoples R China
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GB/T 7714
Luo, X. -H.,Huang, X. -J.,Li, D.,et al. Immune reconstitution to cytomegalovirus following partially matched-related donor transplantation: impact of in vivo T-cell depletion and granulocyte colony-stimulating factor-primed peripheral blood/bone marrow mixed grafts[J]. TRANSPLANT INFECTIOUS DISEASE,2013,15(1):22-33.
APA Luo, X. -H.,Huang, X. -J.,Li, D.,Liu, K. -Y.,Xu, L. -P.,&Liu, D. -H..(2013).Immune reconstitution to cytomegalovirus following partially matched-related donor transplantation: impact of in vivo T-cell depletion and granulocyte colony-stimulating factor-primed peripheral blood/bone marrow mixed grafts.TRANSPLANT INFECTIOUS DISEASE,15(1),22-33.
MLA Luo, X. -H.,et al."Immune reconstitution to cytomegalovirus following partially matched-related donor transplantation: impact of in vivo T-cell depletion and granulocyte colony-stimulating factor-primed peripheral blood/bone marrow mixed grafts".TRANSPLANT INFECTIOUS DISEASE 15.1(2013):22-33.
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