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学科主题: 临床医学
题名:
Immune reconstitution to cytomegalovirus following partially matched-related donor transplantation: impact of in vivo T-cell depletion and granulocyte colony-stimulating factor-primed peripheral blood/bone marrow mixed grafts
作者: Luo, X. -H.; Huang, X. -J.; Li, D.; Liu, K. -Y.; Xu, L. -P.; Liu, D. -H.
关键词: hematopoietic stem cell transplantation ; partially matched ; cytomegalovirus infection ; immune reconstitution ; antigen-specific T cell
刊名: TRANSPLANT INFECTIOUS DISEASE
发表日期: 2013-02-01
DOI: 10.1111/j.1399-3062.2012.00722.x
卷: 15, 期:1, 页:22-33
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology ; Infectious Diseases ; Transplantation
研究领域[WOS]: Immunology ; Infectious Diseases ; Transplantation
关键词[WOS]: IDENTICAL SIBLING TRANSPLANTATION ; INTENSITY CONDITIONING REGIMEN ; VERSUS-HOST-DISEASE ; BONE-MARROW ; ANTITHYMOCYTE GLOBULIN ; HEMATOLOGICAL MALIGNANCIES ; PREEMPTIVE THERAPY ; RECIPIENTS ; INFECTION ; CMV
英文摘要:

Cytomegalovirus (CMV) infection and delayed immune reconstitution remains a serious obstacle for successful partially matched-related donor transplantation (PMRD). We evaluated 42 patients for the development of CMV-specific CD8+ T lymphocytes (CTLCMV) following granulocyte colony-stimulating factor-primed peripheral blood (PB) and bone marrow (BM) with anti-thymocyte globulin (ATG)-based PMRD. PMRD recipients achieved a high frequency, proliferation capacity, and interferon-gamma response of CTLCMV at 1 year post transplantation. CTLCMV with the central memory CD45RO+CD62L+ cell phenotype expanded in PB and BM-resident CTLCMV displayed distinct phenotypes when CMV was reactivated. Although the incidence of CMV reactivation was high in PMRD patients (87.67%), only 11.90% of them developed CMV disease. In conclusion, after PMRD using mixed grafts with ATG-based conditioning, immune recovery to CMV seems to be early and fast, thereby reducing the incidence of CMV disease.

语种: 英语
所属项目编号: 30725038 ; IRT 0702
项目资助者: National Outstanding Young Scientist&prime ; s Foundation of China ; Program for Innovative Research Team in University ; Ministry of Health of China for Huang Xiao-Jun
WOS记录号: WOS:000314651600014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54282
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: Peking Univ, Inst Hematol, Peoples Hosp, Beijing 100044, Peoples R China

Recommended Citation:
Luo, X. -H.,Huang, X. -J.,Li, D.,et al. Immune reconstitution to cytomegalovirus following partially matched-related donor transplantation: impact of in vivo T-cell depletion and granulocyte colony-stimulating factor-primed peripheral blood/bone marrow mixed grafts[J]. TRANSPLANT INFECTIOUS DISEASE,2013,15(1):22-33.
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