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Neutrophil degranulation in antineutrophil cytoplasmic antibody-negative pauci-immune crescentic glomerulonephritis
Wang, Fang1,2; Chen, Min1; Zhao, Ming-Hui1
关键词Antineutrophil Cytoplasmic Antibodies Crescentic Glomerulonephritis Lactoferrin Ngal Pauci-immune Vasculitis
刊名JOURNAL OF NEPHROLOGY
2009-07-01
22期:4页:491-496
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]GELATINASE-ASSOCIATED LIPOCALIN ; RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS ; SMALL-VESSEL VASCULITIS ; CARDIAC-SURGERY ; RENAL INJURY ; LACTOFERRIN ; KIDNEY ; ANCA ; AUTOANTIBODIES ; PROTEINASE-3
英文摘要

Background: Patients with pauci-immune crescentic glomerulonephritis (CrGN) are frequently found to have antineutrophil cytoplasmic antibodies (ANCAs). It has been demonstrated that ANCAs can induce neutrophil activation and degranulation, which plays an important role in the pathogenesis of ANCA-associated vasculitis. However, the pathogenesis of ANCA-negative pauci-immune CrGN is not clear. This study aims to investigate the evidence for neutrophil activation and degranulation at disease presentation in patients with renal biopsy-proven ANCA-negative pauci-immune CrGN.

Methods: Sera from 20 patients with ANCA-negative pauci-immune CrGN and 22 patients with ANCA-positive pauci-immune CrGN were collected at presentation. Serum neutrophil gelatinase-associated lipocalin (NGAL) and lactoferrin (LF) were measured using commercial ELISA kits.

Results: Serum levels of NGAL in ANCA-negative patients were significantly higher than those of ANCA-positive patients (940.8 +/- 676.5 ng/mL vs. 569.3 +/- 287.2 ng/mL, p<0.05). This was still the case after adjustment for renal function. Serum levels of LF in ANCA-negative patients were also significantly higher than those of ANCA-positive patients (24.92 +/- 6.13 U/mL vs. 18.48 +/- 6.89 U/mL, p<0.05).

Conclusion: Neutrophil activation and degranulation occurs in patients with ANCA-negative pauci-immune CrGN in the absence of ANCA, and might be even more prominent than in their ANCA-positive counterparts.

语种英语
WOS记录号WOS:000271853700009
项目编号985-2-104-113
资助机构Chinese 985 project
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54283
专题北京大学第一临床医学院
北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, Hosp 1, Div Renal,Minist Hlth China, Dept Med,Inst Nephrol,Key Lab Renal Dis, Beijing 100034, Peoples R China
2.First Hosp, Dept Med, Div Renal, Ningxia Med Coll, Ningxia, Peoples R China
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GB/T 7714
Wang, Fang,Chen, Min,Zhao, Ming-Hui. Neutrophil degranulation in antineutrophil cytoplasmic antibody-negative pauci-immune crescentic glomerulonephritis[J]. JOURNAL OF NEPHROLOGY,2009,22(4):491-496.
APA Wang, Fang,Chen, Min,&Zhao, Ming-Hui.(2009).Neutrophil degranulation in antineutrophil cytoplasmic antibody-negative pauci-immune crescentic glomerulonephritis.JOURNAL OF NEPHROLOGY,22(4),491-496.
MLA Wang, Fang,et al."Neutrophil degranulation in antineutrophil cytoplasmic antibody-negative pauci-immune crescentic glomerulonephritis".JOURNAL OF NEPHROLOGY 22.4(2009):491-496.
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