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学科主题: 临床医学
题名:
Neutrophil degranulation in antineutrophil cytoplasmic antibody-negative pauci-immune crescentic glomerulonephritis
作者: Wang, Fang1,2; Chen, Min1; Zhao, Ming-Hui1
关键词: Antineutrophil cytoplasmic antibodies ; Crescentic glomerulonephritis ; Lactoferrin ; NGAL ; Pauci-immune ; Vasculitis
刊名: JOURNAL OF NEPHROLOGY
发表日期: 2009-07-01
卷: 22, 期:4, 页:491-496
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: GELATINASE-ASSOCIATED LIPOCALIN ; RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS ; SMALL-VESSEL VASCULITIS ; CARDIAC-SURGERY ; RENAL INJURY ; LACTOFERRIN ; KIDNEY ; ANCA ; AUTOANTIBODIES ; PROTEINASE-3
英文摘要:

Background: Patients with pauci-immune crescentic glomerulonephritis (CrGN) are frequently found to have antineutrophil cytoplasmic antibodies (ANCAs). It has been demonstrated that ANCAs can induce neutrophil activation and degranulation, which plays an important role in the pathogenesis of ANCA-associated vasculitis. However, the pathogenesis of ANCA-negative pauci-immune CrGN is not clear. This study aims to investigate the evidence for neutrophil activation and degranulation at disease presentation in patients with renal biopsy-proven ANCA-negative pauci-immune CrGN.

Methods: Sera from 20 patients with ANCA-negative pauci-immune CrGN and 22 patients with ANCA-positive pauci-immune CrGN were collected at presentation. Serum neutrophil gelatinase-associated lipocalin (NGAL) and lactoferrin (LF) were measured using commercial ELISA kits.

Results: Serum levels of NGAL in ANCA-negative patients were significantly higher than those of ANCA-positive patients (940.8 +/- 676.5 ng/mL vs. 569.3 +/- 287.2 ng/mL, p<0.05). This was still the case after adjustment for renal function. Serum levels of LF in ANCA-negative patients were also significantly higher than those of ANCA-positive patients (24.92 +/- 6.13 U/mL vs. 18.48 +/- 6.89 U/mL, p<0.05).

Conclusion: Neutrophil activation and degranulation occurs in patients with ANCA-negative pauci-immune CrGN in the absence of ANCA, and might be even more prominent than in their ANCA-positive counterparts.

语种: 英语
所属项目编号: 985-2-104-113
项目资助者: Chinese 985 project
WOS记录号: WOS:000271853700009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54283
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Div Renal,Minist Hlth China, Dept Med,Inst Nephrol,Key Lab Renal Dis, Beijing 100034, Peoples R China
2.First Hosp, Dept Med, Div Renal, Ningxia Med Coll, Ningxia, Peoples R China

Recommended Citation:
Wang, Fang,Chen, Min,Zhao, Ming-Hui. Neutrophil degranulation in antineutrophil cytoplasmic antibody-negative pauci-immune crescentic glomerulonephritis[J]. JOURNAL OF NEPHROLOGY,2009,22(4):491-496.
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