IR@PKUHSC  > 北京大学第一临床医学院  > 肾脏内科
学科主题临床医学
Antiglomerular Basement Membrane Disease Associated With Castleman Disease
Lv, Jicheng; Zhang, Hong1; Zhou, Fude; Zou, Wanzhong; Singh, Ajay K.2; Wang, Haiyan
关键词Antiglomerular Basement Membrane Antibodies Castleman Disease Crescentic Glomerulonephritis
刊名AMERICAN JOURNAL OF THE MEDICAL SCIENCES
2009-03-01
337期:3页:206-209
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]LYMPH-NODE HYPERPLASIA ; ANTIBODY
英文摘要

We described a 33-year-old man with gross hematuria and acute renal failure, who had suffered from fever for 6 months, multiple cervical lymph node swelling, splenomegaly, left-sided pleural effusion. He also suffered from anemia, thrombocytopenia, hypergamma-globulinemia, and his serum interleukin-6 levels were markedly elevated. Antiglomerular basement membrane antibodies were positive in the patient′s serum. Lymph node biopsy results were compatible with Castleman disease of "plasma cell" variant. Renal biopsy revealed cellular crescents in most of the glomeruli. Immunofluorescence Studies showed strong deposition of IgG in a linear pattern along the glomerular basement membrane. Pathologic features were compatible with crescentic glomerulonephritis because of antiglomerular basement membrane disease. With intensive plasmapheresis and monthly chemotherapy (cyclophosphamide, oncovin, prednisone regimen), the patient experienced clinical and biochemical remission. Although autoimmune phenomenon had been described frequently in Castleman disease, to the best of our knowledge, this was the first report that the patient with rapid progressive glomerulonephritis mediated by antiglomerular basement membrane antibodies, which might be associated with Castleman disease.

语种英语
WOS记录号WOS:000264370100015
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54285
Collection北京大学第一临床医学院_肾脏内科
作者单位1.Brigham & Womens Hosp, Div Renal, Boston, MA 02115 USA
2.Peking Univ, Hosp 1, Inst Nephrol, Div Renal, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Lv, Jicheng,Zhang, Hong,Zhou, Fude,et al. Antiglomerular Basement Membrane Disease Associated With Castleman Disease[J]. AMERICAN JOURNAL OF THE MEDICAL SCIENCES,2009,337(3):206-209.
APA Lv, Jicheng,Zhang, Hong,Zhou, Fude,Zou, Wanzhong,Singh, Ajay K.,&Wang, Haiyan.(2009).Antiglomerular Basement Membrane Disease Associated With Castleman Disease.AMERICAN JOURNAL OF THE MEDICAL SCIENCES,337(3),206-209.
MLA Lv, Jicheng,et al."Antiglomerular Basement Membrane Disease Associated With Castleman Disease".AMERICAN JOURNAL OF THE MEDICAL SCIENCES 337.3(2009):206-209.
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