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学科主题: 临床医学
题名:
Antiglomerular Basement Membrane Disease Associated With Castleman Disease
作者: Lv, Jicheng; Zhang, Hong1; Zhou, Fude; Zou, Wanzhong; Singh, Ajay K.2; Wang, Haiyan
关键词: Antiglomerular basement membrane antibodies ; Castleman disease ; Crescentic glomerulonephritis
刊名: AMERICAN JOURNAL OF THE MEDICAL SCIENCES
发表日期: 2009-03-01
卷: 337, 期:3, 页:206-209
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: LYMPH-NODE HYPERPLASIA ; ANTIBODY
英文摘要:

We described a 33-year-old man with gross hematuria and acute renal failure, who had suffered from fever for 6 months, multiple cervical lymph node swelling, splenomegaly, left-sided pleural effusion. He also suffered from anemia, thrombocytopenia, hypergamma-globulinemia, and his serum interleukin-6 levels were markedly elevated. Antiglomerular basement membrane antibodies were positive in the patient′s serum. Lymph node biopsy results were compatible with Castleman disease of "plasma cell" variant. Renal biopsy revealed cellular crescents in most of the glomeruli. Immunofluorescence Studies showed strong deposition of IgG in a linear pattern along the glomerular basement membrane. Pathologic features were compatible with crescentic glomerulonephritis because of antiglomerular basement membrane disease. With intensive plasmapheresis and monthly chemotherapy (cyclophosphamide, oncovin, prednisone regimen), the patient experienced clinical and biochemical remission. Although autoimmune phenomenon had been described frequently in Castleman disease, to the best of our knowledge, this was the first report that the patient with rapid progressive glomerulonephritis mediated by antiglomerular basement membrane antibodies, which might be associated with Castleman disease.

语种: 英语
所属项目编号: 985-2-2007-113
项目资助者: Foundation of Ministry of Education, People&prime ; s Republic of China
WOS记录号: WOS:000264370100015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54285
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Brigham & Womens Hosp, Div Renal, Boston, MA 02115 USA
2.Peking Univ, Hosp 1, Inst Nephrol, Div Renal, Beijing 100871, Peoples R China

Recommended Citation:
Lv, Jicheng,Zhang, Hong,Zhou, Fude,et al. Antiglomerular Basement Membrane Disease Associated With Castleman Disease[J]. AMERICAN JOURNAL OF THE MEDICAL SCIENCES,2009,337(3):206-209.
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