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Simulation of Swanson′s Literature-Based Discovery: Anandamide Treatment Inhibits Growth of Gastric Cancer Cells In Vitro and In Silico
Dong, Weiwei1; Liu, Yixuan2; Zhu, Weijie3,4; Mou, Quan5; Wang, Jinliang1; Hu, Yi1
刊名PLOS ONE
2014-06-20
DOI10.1371/journal.pone.0100436
9期:6
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]ENDOCANNABINOID SYSTEM ; HYPOTHESES ; TARGET
英文摘要

Swanson′s literature-based discovery focus on resurrecting previously published but neglected knowledge. In this study, we propose a two-step model of the discovery process and generate a hypothesis between anandamide and gastric cancer. Further, the potential relationship was confirmed by follow-up experimentation. The anandamide treatment resulted in cell cycle redistribution of gastric cancer cells. Most importantly, the variation of cell cycle was mediated by some genes from the B-terms of the closed discovery, indicating the potential role of the B-terms. Swanson′s literature-based discovery not only collates data for possible interactions, but also provides the potential to observe the larger background behind these direct links and is an invaluable discovery tool for investigators.

语种英语
WOS记录号WOS:000338276300074
项目编号CGOS-03-2013-1-1-00600
资助机构Chinese Geriatric Oncology Society
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54286
专题北京大学第三临床医学院_消化科
作者单位1.Gen Hosp PLA, Dept Oncol, Beijing, Peoples R China
2.Peking Univ, Dept Gastroenterol, Hosp 3, Hlth Sci Ctr, Beijing 100871, Peoples R China
3.Beijing Ctr Dis Control & Prevent CDC, Beijing, Peoples R China
4.Ctr Prevent Med Res, Beijing, Peoples R China
5.PLA 252 Hosp, Dept Surg, Baoding, Peoples R China
推荐引用方式
GB/T 7714
Dong, Weiwei,Liu, Yixuan,Zhu, Weijie,et al. Simulation of Swanson′s Literature-Based Discovery: Anandamide Treatment Inhibits Growth of Gastric Cancer Cells In Vitro and In Silico[J]. PLOS ONE,2014,9(6).
APA Dong, Weiwei,Liu, Yixuan,Zhu, Weijie,Mou, Quan,Wang, Jinliang,&Hu, Yi.(2014).Simulation of Swanson′s Literature-Based Discovery: Anandamide Treatment Inhibits Growth of Gastric Cancer Cells In Vitro and In Silico.PLOS ONE,9(6).
MLA Dong, Weiwei,et al."Simulation of Swanson′s Literature-Based Discovery: Anandamide Treatment Inhibits Growth of Gastric Cancer Cells In Vitro and In Silico".PLOS ONE 9.6(2014).
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