IR@PKUHSC  > 北京大学第一临床医学院  > 临床药理研究所
学科主题临床医学
Pharmacokinetics of antofloxacin hydrochloride, a novel fluoroquinolone, after single-dose intravenous administration in healthy Chinese male volunteers
Wang, J.; Xiao, Y.; Lu, Y.; Kang, Z.; Zhang, M.; Liu, Y.; Liang, J.; Zhang, M.; Li, T.
刊名XENOBIOTICA
2010-05-01
DOI10.3109/00498251003649798
40期:5页:344-349
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy ; Toxicology
研究领域[WOS]Pharmacology & Pharmacy ; Toxicology
关键词[WOS]LEVOFLOXACIN ; INFECTION ; RATS
英文摘要

The purpose of the study was to evaluate the pharmacokinetic characteristics of a single, intravenous dose of antofloxacin hydrochloride in healthy Chinese male volunteers.

Twelve subjects were randomly assigned to groups that received a single, intravenous dose of 200, 300, or 400 mg antofloxacin hydrochloride in a three-way crossover design study. The serum and urine concentrations of antofloxacin were then assayed with high-performance liquid chromatography (HPLC). Major pharmacokinetic parameters and urine excretion were obtained up to 96 h after administration.

All three dosages were well tolerated. No clinically adverse reactions or abnormal laboratory results were detected.

After single-dose intravenous administration, antofloxacin hydrochloride exhibited linear pharmacokinetic characteristics with increasing dosages. The C(max) for groups treated with 200, 300, or 400 mg dosages were 2.05 +/- 0.38, 3.01 +/- 0.60, and 3.80 +/- 0.78 mg l

Based on these results, 300 mg of antofloxacin hydrochloride administered once daily is the dose suggested for further investigation in multiple-dose administration studies.

语种英语
WOS记录号WOS:000276414900005
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54287
专题北京大学第一临床医学院_临床药理研究所
北京大学口腔医学院_人事处
作者单位Peking Univ, Inst Clin Pharmacol, Hosp 1, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Wang, J.,Xiao, Y.,Lu, Y.,et al. Pharmacokinetics of antofloxacin hydrochloride, a novel fluoroquinolone, after single-dose intravenous administration in healthy Chinese male volunteers[J]. XENOBIOTICA,2010,40(5):344-349.
APA Wang, J..,Xiao, Y..,Lu, Y..,Kang, Z..,Zhang, M..,...&Li, T..(2010).Pharmacokinetics of antofloxacin hydrochloride, a novel fluoroquinolone, after single-dose intravenous administration in healthy Chinese male volunteers.XENOBIOTICA,40(5),344-349.
MLA Wang, J.,et al."Pharmacokinetics of antofloxacin hydrochloride, a novel fluoroquinolone, after single-dose intravenous administration in healthy Chinese male volunteers".XENOBIOTICA 40.5(2010):344-349.
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