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学科主题: 临床医学
题名:
Pharmacokinetics of antofloxacin hydrochloride, a novel fluoroquinolone, after single-dose intravenous administration in healthy Chinese male volunteers
作者: Wang, J.; Xiao, Y.; Lu, Y.; Kang, Z.; Zhang, M.; Liu, Y.; Liang, J.; Zhang, M.; Li, T.
刊名: XENOBIOTICA
发表日期: 2010-05-01
DOI: 10.3109/00498251003649798
卷: 40, 期:5, 页:344-349
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy ; Toxicology
研究领域[WOS]: Pharmacology & Pharmacy ; Toxicology
关键词[WOS]: LEVOFLOXACIN ; INFECTION ; RATS
英文摘要:

The purpose of the study was to evaluate the pharmacokinetic characteristics of a single, intravenous dose of antofloxacin hydrochloride in healthy Chinese male volunteers.

Twelve subjects were randomly assigned to groups that received a single, intravenous dose of 200, 300, or 400 mg antofloxacin hydrochloride in a three-way crossover design study. The serum and urine concentrations of antofloxacin were then assayed with high-performance liquid chromatography (HPLC). Major pharmacokinetic parameters and urine excretion were obtained up to 96 h after administration.

All three dosages were well tolerated. No clinically adverse reactions or abnormal laboratory results were detected.

After single-dose intravenous administration, antofloxacin hydrochloride exhibited linear pharmacokinetic characteristics with increasing dosages. The C(max) for groups treated with 200, 300, or 400 mg dosages were 2.05 +/- 0.38, 3.01 +/- 0.60, and 3.80 +/- 0.78 mg l

Based on these results, 300 mg of antofloxacin hydrochloride administered once daily is the dose suggested for further investigation in multiple-dose administration studies.

语种: 英语
WOS记录号: WOS:000276414900005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54287
Appears in Collections:北京大学第一临床医学院_临床药理研究所_期刊论文

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作者单位: Peking Univ, Inst Clin Pharmacol, Hosp 1, Beijing 100191, Peoples R China

Recommended Citation:
Wang, J.,Xiao, Y.,Lu, Y.,et al. Pharmacokinetics of antofloxacin hydrochloride, a novel fluoroquinolone, after single-dose intravenous administration in healthy Chinese male volunteers[J]. XENOBIOTICA,2010,40(5):344-349.
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