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学科主题: 药物依赖
题名:
Role of melanin-concentrating hormone in the nucleus accumbens shell in rats behaviourally sensitized to methamphetamine
作者: Sun, Li-li1,2; Zhang, Yan1; Liu, Jian-feng1; Wang, Jun1; Zhu, Wei-li1; Zhao, Li-yan1; Xue, Yan-xue1; Lu, Lin1; Shi, Jie1
关键词: ERK ; melanin-concentrating hormone ; methamphetamine ; nucleus accumbens ; sensitization
刊名: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
发表日期: 2013-09-01
DOI: 10.1017/S1461145713000072
卷: 16, 期:8, 页:1767-1780
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]: Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]: PROTEIN-COUPLED RECEPTOR ; VENTRAL TEGMENTAL AREA ; MEDIUM SPINY NEURONS ; SIGNALING PATHWAY ; GLUTAMATERGIC TRANSMISSION ; LATERAL HYPOTHALAMUS ; SYNAPTIC PLASTICITY ; DOPAMINE-RECEPTORS ; FEEDING-BEHAVIOR ; STRIATAL NEURONS
英文摘要:

Melanin-concentrating hormone (MCH) is a neuropeptide and its receptor is extensively expressed throughout the brain. MCH has been suggested to regulate the rewarding and reinforcing effects of psychostimulants by potentiating the dopaminergic system within the midbrain. Moreover, MCH and its receptor can regulate ERK activity. The present study investigated the role of MCH in the nucleus accumbens (NAc) in rats behaviourally sensitized to methamphetamine (Meth). We found that the development of Meth-induced locomotor sensitization was attenuated by MCH infused into the NAc shell but not core. Moreover, the elevation of ERK phosphorylation in the NAc shell induced by Meth was inhibited by locally infused MCH. Infusion of the MCH receptor 1 (MCHR1) antagonist SNAP 94847 into the NAc shell but not core augmented the initiation of locomotor sensitization and amplitude of elevated phosphorylated ERK levels induced by Meth. The expression of Meth-induced locomotor sensitization and ERK alterations after 1 wk withdrawal were not affected by either MCH or SNAP 94847 infused into the NAc shell or core. These results indicate that MCH in the NAc shell plays a critical role in the development but not expression of Meth-induced locomotor sensitization in rats, which might be mediated by the ERK signalling pathway. Our study suggests that MCH might be a potential target for the treatment of Meth addiction.

语种: 英语
所属项目编号: 2009CB522000 ; 81071079
项目资助者: National Basic Research Program of China ; Natural Science Foundation of China
WOS记录号: WOS:000323166300007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54288
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Tianjin Mental Hlth Ctr, Tianjin, Peoples R China
2.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China

Recommended Citation:
Sun, Li-li,Zhang, Yan,Liu, Jian-feng,et al. Role of melanin-concentrating hormone in the nucleus accumbens shell in rats behaviourally sensitized to methamphetamine[J]. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY,2013,16(8):1767-1780.
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