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Role of melanin-concentrating hormone in the nucleus accumbens shell in rats behaviourally sensitized to methamphetamine
Sun, Li-li1,2; Zhang, Yan1; Liu, Jian-feng1; Wang, Jun1; Zhu, Wei-li1; Zhao, Li-yan1; Xue, Yan-xue1; Lu, Lin1; Shi, Jie1
关键词Erk Melanin-concentrating Hormone Methamphetamine Nucleus Accumbens Sensitization
刊名INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
2013-09-01
DOI10.1017/S1461145713000072
16期:8页:1767-1780
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
资助者National Basic Research Program of China ; Natural Science Foundation of China ; National Basic Research Program of China ; Natural Science Foundation of China
研究领域[WOS]Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]PROTEIN-COUPLED RECEPTOR ; VENTRAL TEGMENTAL AREA ; MEDIUM SPINY NEURONS ; SIGNALING PATHWAY ; GLUTAMATERGIC TRANSMISSION ; LATERAL HYPOTHALAMUS ; SYNAPTIC PLASTICITY ; DOPAMINE-RECEPTORS ; FEEDING-BEHAVIOR ; STRIATAL NEURONS
英文摘要

Melanin-concentrating hormone (MCH) is a neuropeptide and its receptor is extensively expressed throughout the brain. MCH has been suggested to regulate the rewarding and reinforcing effects of psychostimulants by potentiating the dopaminergic system within the midbrain. Moreover, MCH and its receptor can regulate ERK activity. The present study investigated the role of MCH in the nucleus accumbens (NAc) in rats behaviourally sensitized to methamphetamine (Meth). We found that the development of Meth-induced locomotor sensitization was attenuated by MCH infused into the NAc shell but not core. Moreover, the elevation of ERK phosphorylation in the NAc shell induced by Meth was inhibited by locally infused MCH. Infusion of the MCH receptor 1 (MCHR1) antagonist SNAP 94847 into the NAc shell but not core augmented the initiation of locomotor sensitization and amplitude of elevated phosphorylated ERK levels induced by Meth. The expression of Meth-induced locomotor sensitization and ERK alterations after 1 wk withdrawal were not affected by either MCH or SNAP 94847 infused into the NAc shell or core. These results indicate that MCH in the NAc shell plays a critical role in the development but not expression of Meth-induced locomotor sensitization in rats, which might be mediated by the ERK signalling pathway. Our study suggests that MCH might be a potential target for the treatment of Meth addiction.

语种英语
所属项目编号2009CB522000 ; 81071079
资助者National Basic Research Program of China ; Natural Science Foundation of China ; National Basic Research Program of China ; Natural Science Foundation of China
WOS记录号WOS:000323166300007
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54288
Collection中国药物依赖性研究所
作者单位1.Tianjin Mental Hlth Ctr, Tianjin, Peoples R China
2.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Sun, Li-li,Zhang, Yan,Liu, Jian-feng,et al. Role of melanin-concentrating hormone in the nucleus accumbens shell in rats behaviourally sensitized to methamphetamine[J]. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY,2013,16(8):1767-1780.
APA Sun, Li-li.,Zhang, Yan.,Liu, Jian-feng.,Wang, Jun.,Zhu, Wei-li.,...&Shi, Jie.(2013).Role of melanin-concentrating hormone in the nucleus accumbens shell in rats behaviourally sensitized to methamphetamine.INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY,16(8),1767-1780.
MLA Sun, Li-li,et al."Role of melanin-concentrating hormone in the nucleus accumbens shell in rats behaviourally sensitized to methamphetamine".INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY 16.8(2013):1767-1780.
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