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Risk prediction of esophageal squamous-cell carcinoma with common genetic variants and lifestyle factors in Chinese population
Chang, Jiang1,2; Huang, Ying1,2; Wei, Lixuan1,2; Ma, Baoshan3; Miao, Xiaoping4; Li, Yun5; Hu, Zhibin; Yu, Dianke1,2; Jia, Weihua6; Liu, Yu1,2; Tan, Wen1,2; He, Zhonghu7,8; Ke, Yang8; Wu, Tangchun4; Shen, Hongbing7; Zeng, Yixin6; Wu, Chen1,2; Lin, Dongxin1,2
刊名CARCINOGENESIS
2013-08-01
DOI10.1093/carcin/bgt106
34期:8页:1782-1786
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]GENOME-WIDE ASSOCIATION ; CANCER-RISK ; SUSCEPTIBILITY LOCI ; ALCOHOL-DRINKING ; ENVIRONMENT INTERACTIONS ; METAANALYSIS ; POLYMORPHISMS ; BREAST ; PLCE1
英文摘要

Genome-wide association studies have identified multiple genetic variants associated with risk of esophageal squamous-cell carcinoma (ESCC) in Chinese populations. We examined whether these genetic factors, along with non-genetic factors, can contribute to ESCC risk prediction. We examined 25 single nucleotide polymorphisms (SNPs) and 4 non-genetic factors (sex, age, smoking and drinking) associated with ESCC risk in 9805 cases and 10 493 controls from Chinese populations. Weighted genetic risk score (wGRS) was calculated and logistic regression was used to analyze the association between wGRS and ESCC risk. We calculated the area under the curve (AUC) using receiver operating characteristic curve analysis to measure the discrimination after adding genetic variants to the model with only non-genetic factors. Net reclassification improvement (NRI) was used to quantify the degree of correct reclassification using different models. wGRS of the combined 17 SNPs with significant marginal effect (G SNPs) increased similar to 4-fold ESCC risk (P 1.49 10(164)) and the associations were significant in both drinkers and non-drinkers. However, wGRS of the eight SNPs with significant effect in gene drinking interaction (GE SNPs) increased similar to 4-fold ESCC risk only in drinkers (P-interaction 8.76 10(41)). The AUC for a risk model with 4 non-genetic factors, 17 G SNPs, 8 GE SNPs and their interactions with drinking was 70.1%, with the significant improvement of 7.0% compared with the model with only non-genetic factors (P < 0.0001). Our results indicate that incorporating genetic variants, lifestyle factors and their interactions in ESCC risk models can be useful for identifying patients with ESCC.

语种英语
WOS记录号WOS:000322666800010
项目编号2011CB504303
资助机构National Basic Research Program of China
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54301
专题北京大学临床肿瘤学院
北京大学临床肿瘤学院_遗传学研究室
作者单位1.Chinese Acad Med Sci, Canc Inst & Hosp, State Key Lab Mol Oncol, Beijing 100021, Peoples R China
2.Peking Union Med Coll, Beijing 100021, Peoples R China
3.Dalian Maritime Univ, Coll Informat Sci & Technol, Dalian, Liaoning, Peoples R China
4.Huazhong Univ Sci & Technol, Minist Educ, Sch Publ Hlth, Key Lab Environm & Hlth, Wuhan 430074, Hubei, Peoples R China
5.Univ N Carolina, Dept Genet, Chapel Hill, NC USA
6.Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol Southern China, Guangzhou 510275, Guangdong, Peoples R China
7.Nanjing Med Univ, Dept Epidemiol & Biostat, Ctr Canc, Nanjing, Jiangsu, Peoples R China
8.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Chang, Jiang,Huang, Ying,Wei, Lixuan,et al. Risk prediction of esophageal squamous-cell carcinoma with common genetic variants and lifestyle factors in Chinese population[J]. CARCINOGENESIS,2013,34(8):1782-1786.
APA Chang, Jiang.,Huang, Ying.,Wei, Lixuan.,Ma, Baoshan.,Miao, Xiaoping.,...&Lin, Dongxin.(2013).Risk prediction of esophageal squamous-cell carcinoma with common genetic variants and lifestyle factors in Chinese population.CARCINOGENESIS,34(8),1782-1786.
MLA Chang, Jiang,et al."Risk prediction of esophageal squamous-cell carcinoma with common genetic variants and lifestyle factors in Chinese population".CARCINOGENESIS 34.8(2013):1782-1786.
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