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IR@PKUHSC  > 北京大学第三临床医学院  > 肿瘤放疗科  > 期刊论文
学科主题: 临床医学
题名:
CT-guided permanent I-125 seed interstitial brachytherapy for recurrent retroperitoneal lymph node metastases after external beam radiotherapy
作者: Yao, Lihong1; Jiang, Yuliang1; Jiang, Ping1; Wang, Hao1; Meng, Na1; Qu, Ang1; Tian, Suqing1; Sun, Haitao1; Liu, Chen2; Wang, Junjie1; Zhang, Kaixian3
关键词: Re-irradiation ; I-125 seed ; Interstitial brachytherapy ; Retroperitoneal lymph node ; Recurrence
刊名: BRACHYTHERAPY
发表日期: 2015-09-01
DOI: 10.1016/j.brachy.2015.05.008
卷: 14, 期:5, 页:662-669
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Oncology ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: STEREOTACTIC BODY RADIOTHERAPY ; GYNECOLOGIC-ONCOLOGY-GROUP ; SQUAMOUS-CELL CARCINOMA ; SALVAGE THERAPY ; PROSTATE-CANCER ; CLINICAL-OUTCOMES ; CERVICAL-CANCER ; IMPLANTATION ; OLIGOMETASTASES ; RECOMMENDATIONS
英文摘要:

PURPOSE: To evaluate the feasibility, efficacy, and safety of permanent I-125 seed interstitial brachytherapy reirradiation in patients with retroperitoneal lymph node recurrence under CT guidance.

METHODS AND MATERIALS: Seventeen patients with 19 retroperitoneal lymph node recurrence after external beam radiotherapy underwent CT-guided I-125 seed implant brachytherapy from October 2007 to August 2014. Treatment for all patients was preplanned using a three-dimensional radiation therapy planning system 3-5 days before brachytherapy; dosimetry verification was performed immediately after brachytherapy.

RESULTS: The actuarial D90 (dose delivered to 90% of the target volume) was 100-198 Gy (median, 126.5 Gy). In 9 patients, pain intensity decreased to mild pain 1-3 weeks after brachytherapy. Pain-free survival ranged 2-15 months (median, 5 months; 95% confidence interval [CI]: 0.1, 9.9). The overall response rate was 19 of 19 (100%). The median local control time was 15 months (95% CI: 2.3, 27.7). The 6-, 12-, and 24-month local control rate was 88.0%, 63.2%, and 42.1%, respectively. Twelve patients (70.6%) developed distant metastases and died. Two patients (11.8%) are alive with distant metastases but no evidence of local recurrence. Three patients (17.6%) are alive with no evidence of local recurrence. Median overall survival was 10 months (95% CI: 5.7, 14.3); the 1- and 2-year survival rates were 38.1% and 15.3%, respectively. No major complications related to the procedure occurred during or after brachytherapy.

CONCLUSIONS: Reirradiation with CT-guided permanent I-125 seed interstitial brachytherapy is feasible, safe, and effective as pain relief or salvage treatment for patients with recurrent retroperitoneal lymph nodes. (C) 2015 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000361080400011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54303
Appears in Collections:北京大学第三临床医学院_肿瘤放疗科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Radiat Oncol, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Dept Radiol, Beijing 100191, Peoples R China
3.Tengzhou Cent Peoples Hosp, Dept Oncol, Tengzhou 277599, Shangdong, Peoples R China

Recommended Citation:
Yao, Lihong,Jiang, Yuliang,Jiang, Ping,et al. CT-guided permanent I-125 seed interstitial brachytherapy for recurrent retroperitoneal lymph node metastases after external beam radiotherapy[J]. BRACHYTHERAPY,2015,14(5):662-669.
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