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学科主题临床医学
Diffusion-weighted magnetic resonance imaging of focal hepatic nodules in an experimental hepatocellular carcinoma rat model
Xu, Hui; Li, Xuan; Xie, Jing-Xia; Yang, Zheng-Han; Wang, Bin
关键词Magnetic Resonance Imaging Diffusion Hepatocellular Carcinoma Dysplastic Nodules
刊名ACADEMIC RADIOLOGY
2007-03-01
DOI10.1016/j.acra.2006.12.005
14期:3页:279-286
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]INTRAVOXEL INCOHERENT MOTION ; DYSPLASTIC NODULES ; TUMOR NECROSIS ; LIVER-DISEASE ; RABBIT MODEL ; CELL-DEATH ; MR ; PERFUSION ; LESIONS ; CIRRHOSIS
英文摘要

Rationale and Objectives. We sought to investigate the value of diffusion-weighted MR imaging in evaluating focal hepatic nodules in an experimental hepatocellular carcinoma (HCC) rat model. Materials and Methods. Forty rats with chemically induced primary hepatic nodules ranging pathologically from regenerative nodules (RNs) to dysplastic nodules (DNs) to HCC were examined with diffusion-weighted imaging. The apparent diffusion coefficient (ADC) values of hepatic nodular lesions were calculated. Tukey′s HSD post hoc test was used to compare the difference in ADC values between different hepatic nodular lesions. Results. Eight RNs, 16 DNs, 7 well-differentiated HCCs (HCCwell), 11 moderately differentiated HCCs (HCCmod), and 14 poorly differentiated HCCs (HCCpoor) were evaluated. There was no significant difference between RNs and DNs (P > 0.05). Although the ADC values of HCCwell were slightly lower than those of DNs, there was no significant difference between them (P > 0.05). The ADC values of HCCmod and HCCpoor were significantly higher (P < 0.05) than those of other nodules, and no significant difference was seen between HCC od and HCC poor (P > 0.05). Conclusion. Diffusion-weighted magnetic resonance imaging can be useful in characterizing focal hepatic nodular lesions, but ADC values cannot be used efficiently to distinguish HCC,ell from DNs.

语种英语
WOS记录号WOS:000246861100005
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54304
专题北京大学第三临床医学院_放射科
作者单位1.Beijing Hosp, Dept Radiol, Beijing 100730, Peoples R China
2.Weifang Med Univ, Dept Radiol, Weifang 261041, Peoples R China
3.Peking Univ, Dept Radiol, Hosp 3, Beijing 100083, Peoples R China
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Xu, Hui,Li, Xuan,Xie, Jing-Xia,et al. Diffusion-weighted magnetic resonance imaging of focal hepatic nodules in an experimental hepatocellular carcinoma rat model[J]. ACADEMIC RADIOLOGY,2007,14(3):279-286.
APA Xu, Hui,Li, Xuan,Xie, Jing-Xia,Yang, Zheng-Han,&Wang, Bin.(2007).Diffusion-weighted magnetic resonance imaging of focal hepatic nodules in an experimental hepatocellular carcinoma rat model.ACADEMIC RADIOLOGY,14(3),279-286.
MLA Xu, Hui,et al."Diffusion-weighted magnetic resonance imaging of focal hepatic nodules in an experimental hepatocellular carcinoma rat model".ACADEMIC RADIOLOGY 14.3(2007):279-286.
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