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学科主题: 临床医学
题名:
Diffusion-weighted magnetic resonance imaging of focal hepatic nodules in an experimental hepatocellular carcinoma rat model
作者: Xu, Hui; Li, Xuan; Xie, Jing-Xia; Yang, Zheng-Han; Wang, Bin
关键词: magnetic resonance imaging ; diffusion ; hepatocellular carcinoma ; dysplastic nodules
刊名: ACADEMIC RADIOLOGY
发表日期: 2007-03-01
DOI: 10.1016/j.acra.2006.12.005
卷: 14, 期:3, 页:279-286
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: INTRAVOXEL INCOHERENT MOTION ; DYSPLASTIC NODULES ; TUMOR NECROSIS ; LIVER-DISEASE ; RABBIT MODEL ; CELL-DEATH ; MR ; PERFUSION ; LESIONS ; CIRRHOSIS
英文摘要:

Rationale and Objectives. We sought to investigate the value of diffusion-weighted MR imaging in evaluating focal hepatic nodules in an experimental hepatocellular carcinoma (HCC) rat model. Materials and Methods. Forty rats with chemically induced primary hepatic nodules ranging pathologically from regenerative nodules (RNs) to dysplastic nodules (DNs) to HCC were examined with diffusion-weighted imaging. The apparent diffusion coefficient (ADC) values of hepatic nodular lesions were calculated. Tukey′s HSD post hoc test was used to compare the difference in ADC values between different hepatic nodular lesions. Results. Eight RNs, 16 DNs, 7 well-differentiated HCCs (HCCwell), 11 moderately differentiated HCCs (HCCmod), and 14 poorly differentiated HCCs (HCCpoor) were evaluated. There was no significant difference between RNs and DNs (P > 0.05). Although the ADC values of HCCwell were slightly lower than those of DNs, there was no significant difference between them (P > 0.05). The ADC values of HCCmod and HCCpoor were significantly higher (P < 0.05) than those of other nodules, and no significant difference was seen between HCC od and HCC poor (P > 0.05). Conclusion. Diffusion-weighted magnetic resonance imaging can be useful in characterizing focal hepatic nodular lesions, but ADC values cannot be used efficiently to distinguish HCC,ell from DNs.

语种: 英语
WOS记录号: WOS:000246861100005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54304
Appears in Collections:北京大学第三临床医学院_放射科_期刊论文

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作者单位: 1.Beijing Hosp, Dept Radiol, Beijing 100730, Peoples R China
2.Weifang Med Univ, Dept Radiol, Weifang 261041, Peoples R China
3.Peking Univ, Dept Radiol, Hosp 3, Beijing 100083, Peoples R China

Recommended Citation:
Xu, Hui,Li, Xuan,Xie, Jing-Xia,et al. Diffusion-weighted magnetic resonance imaging of focal hepatic nodules in an experimental hepatocellular carcinoma rat model[J]. ACADEMIC RADIOLOGY,2007,14(3):279-286.
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