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Fangchinoline inhibited the antinociceptive effect of morphine in mice
Fang, LH; Zhang, YH; Ku, BS
关键词Fangchinoline Stephania Tetrandra Morphine Serotonin Antinociception Tolerance
刊名PHYTOMEDICINE
2005-03-01
DOI10.1016/j.phymed.2003.06.007
12期:3页:183-188
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Plant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
研究领域[WOS]Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
关键词[WOS]BISBENZYLISOQUINOLINE ALKALOIDS ; FORMALIN TEST ; TOLERANCE ; SEROTONIN ; ANALGESIA ; INVOLVEMENT ; MECHANISMS ; TETRANDRINE ; HISTAMINE ; RELEASE
英文摘要

Fangchinoline (FAN), a non-specific calcium antagonist, is a major alkaloidal component of the creeper Stephania tetrandra S. Moore (or fenfangji). It has been shown to possess antagonistic activity on morphine-induced antinociception in mice. This study was undertaken to assess the antagonistic mechanism. The results demonstrated that FAN (IP) attenuated morphine (SC)-induced antinociception in a dose-dependent manner with significant effect at doses of 30 and 60 mg/kg body wt. (IP) in the tail-flick test but not the tail-pinch tests, carried out in mice. This antagonism was abolished by pretreatment with a serotonin precursor, 5-hydroxytryptophan (5-HTP, IP), but not by pretreatment with a noradrenaline precursor, L-dihydroxyphenylalanine (L-DOPA, IP) in the tail-flick test. On the other hand, the development of morphine-induced analgesic tolerance was not prevented by FAN. These results suggest that the serotonergic pathway may be involved in the antagonism of morphine-induced antinociception by FAN and, in agreement with other reports, also indicates the possible dissociation of the morphine analgesic effect from its tolerance-development mechanism. (c) 2004 Published by Elsevier GmbH.

语种英语
WOS记录号WOS:000229192100004
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54306
专题基础医学院_药理学系
作者单位1.Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing, Peoples R China
2.Chinese Acad Med Sci, Inst Mat Med, Natl Ctr Pharmaceut Screening, Beijing 100050, Peoples R China
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Fang, LH,Zhang, YH,Ku, BS. Fangchinoline inhibited the antinociceptive effect of morphine in mice[J]. PHYTOMEDICINE,2005,12(3):183-188.
APA Fang, LH,Zhang, YH,&Ku, BS.(2005).Fangchinoline inhibited the antinociceptive effect of morphine in mice.PHYTOMEDICINE,12(3),183-188.
MLA Fang, LH,et al."Fangchinoline inhibited the antinociceptive effect of morphine in mice".PHYTOMEDICINE 12.3(2005):183-188.
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