北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 成形外科  > 期刊论文
学科主题: 临床医学
题名:
Engineering skeletal muscle tissue in bioreactor systems
作者: An Yang; Li Dong
关键词: tissue engineering ; regenerative medicine ; skeletal muscle ; bioreactor ; vascularization
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2014-12-05
DOI: 10.3760/cma.j.issn.0366-6999.20141076
卷: 127, 期:23, 页:4130-4139
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: MESENCHYMAL STEM-CELLS ; HYBRID MUSCULAR TISSUES ; BONE-MARROW-CELLS ; CARDIAC TISSUE ; IN-VIVO ; ACETYLCHOLINE-RECEPTORS ; ELECTRICAL-STIMULATION ; FUNCTIONAL-EVALUATION ; COCULTURE SYSTEM ; ADIPOSE-TISSUE
英文摘要:

Objective To give a concise review of the current state of the art in tissue engineering (TE) related to skeletal muscle and kinds of bioreactor environment.

Data sources The review was based on data obtained from the published articles and guidelines.

Study selection A total of 106 articles were selected from several hundred original articles or reviews. The content of selected articles is in accordance with our purpose and the authors are authorized scientists in the study of engineered muscle tissue in bioreactor.

Results Skeletal muscle TE is a promising interdisciplinary field which aims at the reconstruction of skeletal muscle loss. Although numerous studies have indicated that engineering skeletal muscle tissue may be of great importance in medicine in the near future, this technique still represents a limited degree of success. Since tissue-engineered muscle constructs require an adequate connection to the vascular system for efficient transport of oxygen, carbon dioxide, nutrients and waste products. Moreover, functional and clinically applicable muscle constructs depend on adequate neuromuscular junctions with neural cells. Third, in order to engineer muscle tissue successfully, it may be beneficial to mimic the in vivo environment of muscle through association with adequate stimuli from bioreactors.

Conclusion Vascular system and bioreactors are necessary for development and maintenance of engineered muscle in order to provide circulation within the construct.

语种: 英语
WOS记录号: WOS:000347276500024
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54307
Appears in Collections:北京大学第三临床医学院_成形外科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Dept Plast Surg, Hosp 3, Beijing 100191, Peoples R China

Recommended Citation:
An Yang,Li Dong. Engineering skeletal muscle tissue in bioreactor systems[J]. CHINESE MEDICAL JOURNAL,2014,127(23):4130-4139.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[An Yang]'s Articles
[Li Dong]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[An Yang]‘s Articles
[Li Dong]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2018  北京大学医学部 - Feedback
Powered by CSpace