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Procaterol but Not Dexamethasone Protects 16HBE Cells From H2O2-Induced Oxidative Stress
Deng, Zheng1,2; Zhou, Jun-Jun1,2; Sun, Shuang-Yong1,2; Zhao, Xin1,2; Sun, Yi1,2; Pu, Xiao-Ping1,2
关键词Oxidative Stress Procaterol Dexamethasone Nuclear Factor Kappa-b Hydrogen Peroxide
刊名JOURNAL OF PHARMACOLOGICAL SCIENCES
2014-05-01
DOI10.1254/jphs.13206FP
125期:1页:39-50
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]OBSTRUCTIVE PULMONARY-DISEASE ; BRONCHIAL EPITHELIAL-CELLS ; FACTOR-KAPPA-B ; HYDROGEN-PEROXIDE ; RHINOVIRUS INFECTION ; APOPTOSIS ; ASTHMA ; ACTIVATION ; EXPRESSION ; KINASE
英文摘要

Oxidative stress is an important pathophysiological factor of asthma and chronic obstructive pulmonary disease (COPD). We hypothesized that procaterol and dexamethasone might treat inflammation through inhibiting oxidative stress in vitro. This study evaluated procaterol and dexamethasone in the hydrogen peroxide (H2O2)-induced immortal human bronchial epithelial cell model of oxidative stress and investigated the underlying mechanisms. Results showed that exposure to 125 mu M H2O2 for 2 h led to a 50% reduction in the cell viability, significantly increased the percentage of apoptosis, and elevated levels of malondialdehyde and reactive oxygen species. Pretreatment with procaterol (25 200 nM) could reduce these effects in a dose-dependent manner. In contrast, pretreatment with dexamethasone (100 nM, 1000 nM) was inefficient. Pretreatment with procaterol plus dexamethasone (100 nM procaterol + 1000 nM dexamethasone) was effective, but the combined effect was not more effective than the sole pretreatment with 100 nM procaterol. The nuclear factor kappa-B (NF-kappa B) pathway was involved in the pathogenic mechanisms of H2O2. Procaterol may indirectly inhibit H2O2-induced activation of the NF-kappa B pathway due to its capability of antioxidation. Glucocorticoids may be not recommended to treat asthma or COPD complicated with severe oxidative stress.

语种英语
WOS记录号WOS:000336556600003
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54315
专题北京大学药学院
北京大学药学院_分子与细胞药理学系
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Mol & Cellular Pharmacol, Beijing 100191, Peoples R China
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GB/T 7714
Deng, Zheng,Zhou, Jun-Jun,Sun, Shuang-Yong,et al. Procaterol but Not Dexamethasone Protects 16HBE Cells From H2O2-Induced Oxidative Stress[J]. JOURNAL OF PHARMACOLOGICAL SCIENCES,2014,125(1):39-50.
APA Deng, Zheng,Zhou, Jun-Jun,Sun, Shuang-Yong,Zhao, Xin,Sun, Yi,&Pu, Xiao-Ping.(2014).Procaterol but Not Dexamethasone Protects 16HBE Cells From H2O2-Induced Oxidative Stress.JOURNAL OF PHARMACOLOGICAL SCIENCES,125(1),39-50.
MLA Deng, Zheng,et al."Procaterol but Not Dexamethasone Protects 16HBE Cells From H2O2-Induced Oxidative Stress".JOURNAL OF PHARMACOLOGICAL SCIENCES 125.1(2014):39-50.
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