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The antidepressant effect of secoisolariciresinol, a lignan-type phytoestrogen constituent of flaxseed, on ovariectomized mice
Wang, Ying-Feng2; Xu, Zhi-Kun2; Yang, Dong-Hui1; Yao, Hai-Yan3; Ku, Bao-Shan3; Ma, Xiao-Qing1; Wang, Cheng-Zhi3; Liu, Shu-Lin4; Cai, Shao-Qing1
关键词Secoisolariciresinol Ovariectomized Mice Forced Swimming Tail Suspension Monoamine Level
刊名JOURNAL OF NATURAL MEDICINES
2013
DOI10.1007/s11418-012-0655-x
67期:1页:222-227
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]HUMAN INTESTINAL BACTERIA ; ANTIOXIDANT ACTIVITY ; ENTEROLACTONE ; ENTERODIOL ; METABOLITES ; DEPRESSION ; EXTRACT ; WOMEN
英文摘要

Secoisolariciresinol (SECO) is a natural lignan-type phytoestrogen constituent mainly found in flaxseed. It can be metabolized in vivo to mammalian lignans of enterodiol and enterolactone, which have been proven to be effective in relieving menopausal syndrome. Depression is one of the most common symptoms of menopausal syndrome, and is currently treated with estrogen replacement and antidepressant therapy. However, due to the serious side-effects of such agents, there are urgent needs for safer and more tolerable treatments. In this paper, using two classical depression models, the forced swimming test and the tail suspension test, we report the antidepressant effect of SECO on ovariectomized (OVX) mice by intragastric administration for 14 consecutive days at doses of 5, 10 and 20 mg/kg. The results showed that SECO (10 mg/kg) treatment could significantly reduce the duration of immobility of OVX mice in these two models compared with the control group (OVX mice + vehicle), which was similar to the positive control imipramine. In addition, SECO treatment could substantially increase brain monoamine (norepinephrine and dopamine) levels in OVX mice. The present studies showed that SECO can reverse depressive-like behavior and exhibit monoamine-enhancing effects.

语种英语
WOS记录号WOS:000312408400029
项目编号30672622 ; 2011ZX09102-011
资助机构National Natural Science Foundation ; National Science and Technology Major Projects for "Major New Drugs Innovation and Development&prime ; &prime ; of China
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54318
专题北京大学药学院
北京大学基础医学院
北京大学药学院_天然药物学系
北京大学医学图书馆_信息咨询部
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Capital Normal Univ, Dept Chem, Beijing 100048, Peoples R China
3.Peking Univ, Sch Basic Med Sci, Beijing 100191, Peoples R China
4.Harbin Med Univ, Sch Pharmaceut Sci, Harbin 150081, Peoples R China
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GB/T 7714
Wang, Ying-Feng,Xu, Zhi-Kun,Yang, Dong-Hui,et al. The antidepressant effect of secoisolariciresinol, a lignan-type phytoestrogen constituent of flaxseed, on ovariectomized mice[J]. JOURNAL OF NATURAL MEDICINES,2013,67(1):222-227.
APA Wang, Ying-Feng.,Xu, Zhi-Kun.,Yang, Dong-Hui.,Yao, Hai-Yan.,Ku, Bao-Shan.,...&Cai, Shao-Qing.(2013).The antidepressant effect of secoisolariciresinol, a lignan-type phytoestrogen constituent of flaxseed, on ovariectomized mice.JOURNAL OF NATURAL MEDICINES,67(1),222-227.
MLA Wang, Ying-Feng,et al."The antidepressant effect of secoisolariciresinol, a lignan-type phytoestrogen constituent of flaxseed, on ovariectomized mice".JOURNAL OF NATURAL MEDICINES 67.1(2013):222-227.
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