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学科主题: 药学
题名:
The antidepressant effect of secoisolariciresinol, a lignan-type phytoestrogen constituent of flaxseed, on ovariectomized mice
作者: Wang, Ying-Feng2; Xu, Zhi-Kun2; Yang, Dong-Hui1; Yao, Hai-Yan3; Ku, Bao-Shan3; Ma, Xiao-Qing1; Wang, Cheng-Zhi3; Liu, Shu-Lin4; Cai, Shao-Qing1
关键词: Secoisolariciresinol ; Ovariectomized mice ; Forced swimming ; Tail suspension ; Monoamine level
刊名: JOURNAL OF NATURAL MEDICINES
发表日期: 2013
DOI: 10.1007/s11418-012-0655-x
卷: 67, 期:1, 页:222-227
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: HUMAN INTESTINAL BACTERIA ; ANTIOXIDANT ACTIVITY ; ENTEROLACTONE ; ENTERODIOL ; METABOLITES ; DEPRESSION ; EXTRACT ; WOMEN
英文摘要:

Secoisolariciresinol (SECO) is a natural lignan-type phytoestrogen constituent mainly found in flaxseed. It can be metabolized in vivo to mammalian lignans of enterodiol and enterolactone, which have been proven to be effective in relieving menopausal syndrome. Depression is one of the most common symptoms of menopausal syndrome, and is currently treated with estrogen replacement and antidepressant therapy. However, due to the serious side-effects of such agents, there are urgent needs for safer and more tolerable treatments. In this paper, using two classical depression models, the forced swimming test and the tail suspension test, we report the antidepressant effect of SECO on ovariectomized (OVX) mice by intragastric administration for 14 consecutive days at doses of 5, 10 and 20 mg/kg. The results showed that SECO (10 mg/kg) treatment could significantly reduce the duration of immobility of OVX mice in these two models compared with the control group (OVX mice + vehicle), which was similar to the positive control imipramine. In addition, SECO treatment could substantially increase brain monoamine (norepinephrine and dopamine) levels in OVX mice. The present studies showed that SECO can reverse depressive-like behavior and exhibit monoamine-enhancing effects.

语种: 英语
所属项目编号: 30672622 ; 2011ZX09102-011
项目资助者: National Natural Science Foundation ; National Science and Technology Major Projects for "Major New Drugs Innovation and Development&prime ; &prime ; of China
WOS记录号: WOS:000312408400029
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54318
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Capital Normal Univ, Dept Chem, Beijing 100048, Peoples R China
3.Peking Univ, Sch Basic Med Sci, Beijing 100191, Peoples R China
4.Harbin Med Univ, Sch Pharmaceut Sci, Harbin 150081, Peoples R China

Recommended Citation:
Wang, Ying-Feng,Xu, Zhi-Kun,Yang, Dong-Hui,et al. The antidepressant effect of secoisolariciresinol, a lignan-type phytoestrogen constituent of flaxseed, on ovariectomized mice[J]. JOURNAL OF NATURAL MEDICINES,2013,67(1):222-227.
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