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学科主题: 临床医学
题名:
Long intergenic non-coding RNA TUG1 is overexpressed in urothelial carcinoma of the bladder
作者: Han, Yonghua1,2,3; Liu, Yuchen1,2,4; Gui, Yaoting1,2; Cai, Zhiming1,2,3
关键词: lincRNA ; taurine up-regulated gene 1 ; bladder cancer ; proliferation ; apoptosis
刊名: JOURNAL OF SURGICAL ONCOLOGY
发表日期: 2013-04-01
DOI: 10.1002/jso.23264
卷: 107, 期:5, 页:555-559
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Surgery
研究领域[WOS]: Oncology ; Surgery
关键词[WOS]: GENE-EXPRESSION ; CANCER
英文摘要:

Background and Objectives Long intergenic non-coding RNAs (lincRNAs) are a class of non-coding RNAs that regulate gene expression via chromatin reprogramming. Taurine Up-regulated Gene 1 (TUG1) is a lincRNA that is associated with chromatin-modifying complexes and plays roles in gene regulation. In this study, we determined the expression patterns of TUG1 and the cell proliferation inhibition and apoptosis induced by silencing TUG1 in urothelial carcinoma of the bladder. Methods The expression levels of TUG1 were determined using Real-Time qPCR in a total of 44 patients with bladder urothelial carcinomas. Bladder urothelial carcinoma T24 and 5637 cells were transfected with TUG1 siRNA or negative control siRNA. Cell proliferation was evaluated using MTT assay. Apoptosis was determined using ELISA assay. Results TUG1 was up-regulated in bladder urothelial carcinoma compared to paired normal urothelium. High TUG1 expression levels were associated with high grade and stage carcinomas. Cell proliferation inhibition and apoptosis induction were observed in TUG1 siRNA-transfected bladder urothelial carcinoma T24 and 5637 cells. Conclusions Our data suggest that lincRNA TUG1 is emerging as a novel player in the disease state of bladder urothelial carcinoma. TUG1 may have potential roles as a biomarker and/or a therapeutic target in bladder urothelial carcinoma. J. Surg. Oncol. 2013;107:555559. (c) 2012 Wiley Periodicals, Inc.

语种: 英语
所属项目编号: 2009AA022707 ; CXB201005250016A ; CXC201005260001A ; 2009AA022707
项目资助者: National High Technology Research and Development Program of China ; Promotion Program for Shenzhen Key Laboratory, Shenzhen, China ; Bank of Clinical Data of Major Diseases and Biological Specimens of Shenzhen ; National High Technology Research and Development Program of China (863 Program)
WOS记录号: WOS:000316964700018
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54321
Appears in Collections:北京大学深圳医院_期刊论文

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作者单位: 1.Anhui Med Univ, Hefei, Peoples R China
2.Peking Univ, Guangdong Key Lab Male Reprod Med & Genet, Shenzhen Hosp, Shenzhen 518036, Peoples R China
3.Shenzhen PKU HKUST Med Ctr, Inst Urol, Shenzhen, Peoples R China
4.Shenzhen Second Peoples Hosp, Cent Lab, Shenzhen, Peoples R China

Recommended Citation:
Han, Yonghua,Liu, Yuchen,Gui, Yaoting,et al. Long intergenic non-coding RNA TUG1 is overexpressed in urothelial carcinoma of the bladder[J]. JOURNAL OF SURGICAL ONCOLOGY,2013,107(5):555-559.
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