学科主题 | 临床医学 |
How Histopathology Can Contribute to an Understanding of Defense Mechanisms against Cryptococci | |
Okubo, Yoichiro1; Tochigi, Naobumi1; Wakayama, Megumi1; Shinozaki, Minoru1; Nakayama, Haruo2; Ishiwatari, Takao1; Shimodaira, Kayoko1; Nemoto, Tetsuo1; Ohno, Hideaki3; Kaneko, Yukihiro3; Makimura, Koichi4; Uchida, Katsuhisa5; Miyazaki, Yoshitsugu3; Yamaguchi, Hideyo5; Shibuya, Kazutoshi1,6 | |
刊名 | MEDIATORS OF INFLAMMATION
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2013 | |
DOI | 10.1155/2013/465319 |
收录类别 | SCI |
文章类型 | Review |
WOS标题词 | Science & Technology |
类目[WOS] | Cell Biology ; Immunology |
资助者 | Ministry of Health, Labor, and Welfare of Japan ; Strategic Basis on Research Grounds for Nongovernmental Schools at Heisei ; Strategic Research Foundation ; Ministry of Education, Culture, Sports, Science, and Technology of Japan ; Toho University ; Yokohama Foundation for Advancement of Medical Science ; Toho University Medical School ; Ministry of Health, Labor, and Welfare of Japan ; Strategic Basis on Research Grounds for Nongovernmental Schools at Heisei ; Strategic Research Foundation ; Ministry of Education, Culture, Sports, Science, and Technology of Japan ; Toho University ; Yokohama Foundation for Advancement of Medical Science ; Toho University Medical School |
研究领域[WOS] | Cell Biology ; Immunology |
关键词[WOS] | BRITISH-COLUMBIA ; NEOFORMANS ; GATTII ; INFECTION ; OUTBREAK ; CANADA ; SPREAD ; SYSTEM |
英文摘要 | Invasive fungal infections, particularly those considered opportunistic, have become a common and significant complication of procedures performed in advanced contemporary medicine. Among such infections, cryptococcosis, which is usually caused by infection with Cryptococcus neoformans and Cryptococcus gattii, is particularly problematic because this fungal infection occurs in immunocompromised and apparently immunocompetent individuals. It has been largely accepted that Cryptococcus species are recognized by cellular receptors and that Th1-type immune responses play an important role in defense mechanisms against the yeast. However, the interaction between the yeast and host tissue varies depending on the characteristics of the yeast and the immune status of the host. To gain a better understanding of the pathophysiology of cryptococcosis, we wish to emphasize the usefulness of histopathological examinations, because it allowed more detailed information of an extremely complex interaction between the causative yeasts and tissue response. In the present review, we describe the pathophysiology of cryptococcosis as largely revealed in our previous histopathological investigations of the experimental infection. |
语种 | 英语 |
所属项目编号 | H25-shinko-ippan-006 ; H23-Shinkou-Ippan-018 ; 24790364 ; 23-19 ; 21 ; 28 ; 24-11 ; 16 ; 27 |
资助者 | Ministry of Health, Labor, and Welfare of Japan ; Strategic Basis on Research Grounds for Nongovernmental Schools at Heisei ; Strategic Research Foundation ; Ministry of Education, Culture, Sports, Science, and Technology of Japan ; Toho University ; Yokohama Foundation for Advancement of Medical Science ; Toho University Medical School ; Ministry of Health, Labor, and Welfare of Japan ; Strategic Basis on Research Grounds for Nongovernmental Schools at Heisei ; Strategic Research Foundation ; Ministry of Education, Culture, Sports, Science, and Technology of Japan ; Toho University ; Yokohama Foundation for Advancement of Medical Science ; Toho University Medical School |
WOS记录号 | WOS:000324027300001 |
Citation statistics | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.bjmu.edu.cn/handle/400002259/54322 |
Collection | 北京大学第一临床医学院_皮肤性病科 |
作者单位 | 1.Teikyo Univ, Inst Med Mycol, Hachioji, Tokyo 1920395, Japan 2.Toho Univ, Sch Med, Dept Surg Pathol, Ota Ku, Tokyo 1438541, Japan 3.Toho Univ, Ohashi Med Ctr, Dept Neurosurg, Meguro Ku, Tokyo 1538515, Japan 4.Natl Inst Infect Dis, Dept Chemotherapy & Mycoses, Shinjuku Ku, Tokyo 1628640, Japan 5.Teikyo Univ, Grad Sch Med, Lab Space & Environm Med, Itabashi Ku, Tokyo 1738605, Japan 6.Peking Univ, Dept Dermatol, Hosp 1, Beijing 100871, Peoples R China |
Recommended Citation GB/T 7714 | Okubo, Yoichiro,Tochigi, Naobumi,Wakayama, Megumi,et al. How Histopathology Can Contribute to an Understanding of Defense Mechanisms against Cryptococci[J]. MEDIATORS OF INFLAMMATION,2013. |
APA | Okubo, Yoichiro.,Tochigi, Naobumi.,Wakayama, Megumi.,Shinozaki, Minoru.,Nakayama, Haruo.,...&Shibuya, Kazutoshi.(2013).How Histopathology Can Contribute to an Understanding of Defense Mechanisms against Cryptococci.MEDIATORS OF INFLAMMATION. |
MLA | Okubo, Yoichiro,et al."How Histopathology Can Contribute to an Understanding of Defense Mechanisms against Cryptococci".MEDIATORS OF INFLAMMATION (2013). |
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