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学科主题: 临床医学
题名:
How Histopathology Can Contribute to an Understanding of Defense Mechanisms against Cryptococci
作者: Okubo, Yoichiro1; Tochigi, Naobumi1; Wakayama, Megumi1; Shinozaki, Minoru1; Nakayama, Haruo2; Ishiwatari, Takao1; Shimodaira, Kayoko1; Nemoto, Tetsuo1; Ohno, Hideaki3; Kaneko, Yukihiro3; Makimura, Koichi4; Uchida, Katsuhisa5; Miyazaki, Yoshitsugu3; Yamaguchi, Hideyo5; Shibuya, Kazutoshi1,6
刊名: MEDIATORS OF INFLAMMATION
发表日期: 2013
DOI: 10.1155/2013/465319
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Immunology
研究领域[WOS]: Cell Biology ; Immunology
关键词[WOS]: BRITISH-COLUMBIA ; NEOFORMANS ; GATTII ; INFECTION ; OUTBREAK ; CANADA ; SPREAD ; SYSTEM
英文摘要:

Invasive fungal infections, particularly those considered opportunistic, have become a common and significant complication of procedures performed in advanced contemporary medicine. Among such infections, cryptococcosis, which is usually caused by infection with Cryptococcus neoformans and Cryptococcus gattii, is particularly problematic because this fungal infection occurs in immunocompromised and apparently immunocompetent individuals. It has been largely accepted that Cryptococcus species are recognized by cellular receptors and that Th1-type immune responses play an important role in defense mechanisms against the yeast. However, the interaction between the yeast and host tissue varies depending on the characteristics of the yeast and the immune status of the host. To gain a better understanding of the pathophysiology of cryptococcosis, we wish to emphasize the usefulness of histopathological examinations, because it allowed more detailed information of an extremely complex interaction between the causative yeasts and tissue response. In the present review, we describe the pathophysiology of cryptococcosis as largely revealed in our previous histopathological investigations of the experimental infection.

语种: 英语
所属项目编号: H25-shinko-ippan-006 ; H23-Shinkou-Ippan-018 ; 24790364 ; 23-19 ; 21 ; 28 ; 24-11 ; 16 ; 27
项目资助者: Ministry of Health, Labor, and Welfare of Japan ; Strategic Basis on Research Grounds for Nongovernmental Schools at Heisei ; Strategic Research Foundation ; Ministry of Education, Culture, Sports, Science, and Technology of Japan ; Toho University ; Yokohama Foundation for Advancement of Medical Science ; Toho University Medical School
WOS记录号: WOS:000324027300001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54322
Appears in Collections:北京大学第一临床医学院_皮肤性病科_期刊论文

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作者单位: 1.Teikyo Univ, Inst Med Mycol, Hachioji, Tokyo 1920395, Japan
2.Toho Univ, Sch Med, Dept Surg Pathol, Ota Ku, Tokyo 1438541, Japan
3.Toho Univ, Ohashi Med Ctr, Dept Neurosurg, Meguro Ku, Tokyo 1538515, Japan
4.Natl Inst Infect Dis, Dept Chemotherapy & Mycoses, Shinjuku Ku, Tokyo 1628640, Japan
5.Teikyo Univ, Grad Sch Med, Lab Space & Environm Med, Itabashi Ku, Tokyo 1738605, Japan
6.Peking Univ, Dept Dermatol, Hosp 1, Beijing 100871, Peoples R China

Recommended Citation:
Okubo, Yoichiro,Tochigi, Naobumi,Wakayama, Megumi,et al. How Histopathology Can Contribute to an Understanding of Defense Mechanisms against Cryptococci[J]. MEDIATORS OF INFLAMMATION,2013.
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