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Antineutrophil autoantibodies and their target antigens in systemic lupus erythematosus
Chen, M; Zhao, MH; Zhang, Y; Wang, H
关键词Autoantibodies Autoantigen Neutrophils Sle
刊名LUPUS
2004
DOI10.1191/0961203303lu1071oa
13期:8页:584-589
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Rheumatology
研究领域[WOS]Rheumatology
关键词[WOS]CYTOPLASMIC ANTIBODIES ; CLINICAL ASSOCIATIONS ; DISEASE-ACTIVITY ; NEUTROPENIA ; SPECIFICITY ; LACTOFERRIN ; NEUTROPHILS ; PREVALENCE ; NEPHRITIS
英文摘要

Various autoantibodies have been identified in sera from patients with systemic lupus erythematosus (SLE) and autoantibodies against neutrophil have been reported. It was suggested that antineutrophil autoantibodies might be involved in the pathogenesis of neutrocytopenia; however, the role of autoantibodies against neutrophil precursors and their specific target autoantigen(s) remained further characterized. The objective was to investigate the target antigens and clinical associations of autoantibodies against neutrophils and neutrophil precursors in patients with SLE. Sera were collected from 92 patients with SLE and renal biopsy proven lupus nephritis. Cell lysates of peripheral neutrophils ( as mature neutrophils) from a normal blood donor and white blood cells from a patient with blast crisis of chronic granulocytic leukemia (CGL) ( as neutrophil precursors) were used as antigens in Western blot analysis to detect autoantibodies in sera from patients with SLE. The clinical significance of antineutrophil autoantibodies that recognized different antigens were further analysed. Using normal peripheral neutrophils as antigens, two bands could be blotted: 64 kD (33/92, 35.9%) and 50 kD (13/92, 14.1%). The prevalence of anti-64 kD autoantibody in patients with positive rheumatic factor was significantly higher than that in patients without (54.5 versus 18.8%, P< 0.05). Using CGL white cells as antigen, five bands could be blotted: 60 kD (34/92, 37.0%), 50 kD (32/92, 34.8%), 29 kD (27/92, 29.3%), 42 kD (19/92, 20.7%) and 18 kD (16/92, 17.4%). The prevalence of anti-60 kD autoantibody was significantly higher in patients with neutrocytopenia than that in patients without neutrocytopenia (100 versus 48.3%, P< 0.01). The prevalence of anti-29 kD autoantibody was significantly higher in patients with alopecia than that in patients without alopecia (45.8 versus 20.8%, P< 0.05). Furthermore, the prevalences of anti-60 kD, anti-50 kD and anti-42 kD autoantibodies were significantly higher in patients with anti-Ro autoantibody than those in patients without; the prevalences of anti-29 kD and anti-18 kD autoantibodies were significantly higher in patients with anti-Sm autoantibody than those in patients without. We conclude that there are heterogeneous autoantibodies against both neutrophils and their precursors in sera from patients with SLE. Different autoantibodies may have different clinical significance.

语种英语
WOS记录号WOS:000223639000005
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54329
专题北京大学第一临床医学院_肾脏内科
作者单位Peking Univ, Hosp 1, Dept Nephrol, Beijing 100034, Peoples R China
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GB/T 7714
Chen, M,Zhao, MH,Zhang, Y,et al. Antineutrophil autoantibodies and their target antigens in systemic lupus erythematosus[J]. LUPUS,2004,13(8):584-589.
APA Chen, M,Zhao, MH,Zhang, Y,&Wang, H.(2004).Antineutrophil autoantibodies and their target antigens in systemic lupus erythematosus.LUPUS,13(8),584-589.
MLA Chen, M,et al."Antineutrophil autoantibodies and their target antigens in systemic lupus erythematosus".LUPUS 13.8(2004):584-589.
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