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Treatment Responses of Procaterol and CD38 Inhibitors in an Ozone-Induced Airway Hyperresponsiveness Mice Model
Deng, Zheng1,2; Gao, Zhan-Cheng3; Ge, Hui-Qi1,2; Zhang, Liang-Ren1; Zhou, Jun-Jun1,2; Zhu, Zhi-Peng1; Wu, Dong-Ying1; Sun, Shuang-Yong1,2; Chen, Lin3; Pu, Xiao-Ping1,2
关键词Airway Hyperresponsiveness Cd38 Inhibitor Procaterol Ozone Exposure Inflammation Nuclear Factor-kappab
刊名BIOLOGICAL & PHARMACEUTICAL BULLETIN
2013-08-01
36期:8页:1348-1355
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]BRONCHIAL EPITHELIAL-CELLS ; SMOOTH-MUSCLE-CELLS ; NF-KAPPA-B ; TNF-ALPHA ; AMBIENT OZONE ; LUNG INJURY ; EXPRESSION ; ASTHMA ; INFLAMMATION ; EXPOSURE
英文摘要

Airway hyperresponsiveness (AHR) and airway inflammation are key pathophysiological features of many respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD). To evaluate the treatment responses of procaterol and CD38 inhibitors in an ozone-induced AHR mice model, we hypothesized that procaterol and two synthetic CD38 inhibitors (Compounds T and H) might have therapeutic effects on the ozone-induced AHR mice model, and the nuclear factor-kappaB (NF-kappa B) pathway and the CD38 enzymatic activity might be involved in the mechanisms. With the exception of the Control group, ozone exposure was used to establish an AHR model. Male Kunming mice in the Procaterol and CD38 inhibitors groups were treated with an emulsifier of procaterol hydrochloride, Compound T or H. Results indicated that (1) no drug showed severe toxicity in this study; (2) ozone exposure induced airway inflammation and AHR; (3) intragastric treatment with procaterol and Compound T achieved potent therapeutic effects, but Compound H did not show any therapeutic effect; (4) the NF-kappa B pathway was involved in both the pathogenic mechanisms of ozone and therapeutic mechanisms of procaterol and Compound T; (5) however, the in vivo effect of Compound T was not caused by its inhibitory activity on CD38. Taken together, procaterol and Compound T are potentially good drugs to treat asthma and COPD complicated with ozone exposure.

语种英语
WOS记录号WOS:000322691700020
项目编号NSFC 91213302
资助机构Research Fund of the State Key Laboratory of Natural and Biomimetic Drugs, Peking University, People&prime ; s Republic of China ; National Natural Science Foundation of China
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54330
专题北京大学药学院
北京大学药学院_药物化学系
北京大学药学院_分子与细胞药理学系
北京大学第二临床医学院_呼吸科
作者单位1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Mol & Cellular Pharmacol, Beijing 100191, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Resp & Crit Care Med, Beijing 100044, Peoples R China
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GB/T 7714
Deng, Zheng,Gao, Zhan-Cheng,Ge, Hui-Qi,et al. Treatment Responses of Procaterol and CD38 Inhibitors in an Ozone-Induced Airway Hyperresponsiveness Mice Model[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2013,36(8):1348-1355.
APA Deng, Zheng.,Gao, Zhan-Cheng.,Ge, Hui-Qi.,Zhang, Liang-Ren.,Zhou, Jun-Jun.,...&Pu, Xiao-Ping.(2013).Treatment Responses of Procaterol and CD38 Inhibitors in an Ozone-Induced Airway Hyperresponsiveness Mice Model.BIOLOGICAL & PHARMACEUTICAL BULLETIN,36(8),1348-1355.
MLA Deng, Zheng,et al."Treatment Responses of Procaterol and CD38 Inhibitors in an Ozone-Induced Airway Hyperresponsiveness Mice Model".BIOLOGICAL & PHARMACEUTICAL BULLETIN 36.8(2013):1348-1355.
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