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学科主题: 临床医学
题名:
A Concise Review of Current Radiopharmaceuticals in Tumor Angiogenesis Imaging
作者: Lu, Xia1,2,3; Wang, Rong Fu1
关键词: Tumor angiogenesis ; Vascular endothelial growth factor ; Vascular endothelial growth factor receptor ; Integrin alpha(v)beta(3) ; Peptide RGD ; Peptide RRL ; Tumor molecular imaging ; Targeted therapy
刊名: CURRENT PHARMACEUTICAL DESIGN
发表日期: 2012-03-01
卷: 18, 期:8, 页:1032-1040
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: CYCLIC RGD PEPTIDES ; BINDING PEPTIDES ; CANCER ; INTEGRIN ; PET ; EXPRESSION ; THERAPY ; AGENT ; ALPHA-V-BETA-3 ; CONFORMATION
英文摘要:

Angiogenesis is necessary for tumor growth, without which a tumor can not grow beyond a few millimeters in diameter. This review summarizes the current status on the research of peptide Arg-Gly-Asp (RGD) and Arg-Arg-Leu (RRL) as well as its derivatives applied in tumor angiogenesis imaging and targeted therapy with single photon emission tomography (SPECT) and positron emission tomography (PET). Peptide RGD sequence Arg-Gly-Asp targeted and combined to integrin alpha(v)beta(3) which has been overexpressed on tumor endothelial cells and many different tumor cells is a robust site for tumor angiogenesis molecular imaging and targeted therapy. The various derivatives of RGD were focused on optimizing its biological characteristics including affinity, targeting efficacy and pharmacokinetics. The other alternative novel tumor angiogenesis molecular imaging agent is RRL peptide which targeted to tumor derived endothelial cells and then applied to visualize tumor angiogenesis with enhanced ultrasonic imaging, optical imaging and SPECT in animal. These novel peptide agents can have promising applications for tumor angiogenesis imaging and antiangiogenic tumor therapy.

语种: 英语
所属项目编号: 30870729 ; 81071183 ; 30900374 ; 2006CB705705-1 ; 985-2-056 ; 200800011061
项目资助者: Natural Science Foundation of China (NSFC) ; National Basic Research Program of China (973 Program) ; National Education Ministry ; Research Fund for the Doctoral Program of Higher Education of China
WOS记录号: WOS:000304445900003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54332
Appears in Collections:北京大学第一临床医学院_核医学科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Nucl Med, Beijing 100034, Peoples R China
2.Beijing Normal Univ, Coll Chem, Minist Educ, Key Lab Radiopharmaceut, Beijing 100875, Peoples R China
3.Beijing Aeroapace Gen Hosp, Radiol Ctr, Beijing 100076, Peoples R China

Recommended Citation:
Lu, Xia,Wang, Rong Fu. A Concise Review of Current Radiopharmaceuticals in Tumor Angiogenesis Imaging[J]. CURRENT PHARMACEUTICAL DESIGN,2012,18(8):1032-1040.
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