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学科主题: 基础医学
题名:
Long-term survival of cardiac allografts induced by cyclophosphamide combined with CTLA4Ig-gene transfer mediated by adenoviral vector
作者: Wang, G. M.; Ma, J. B.; Jin, Y. Z.; Feng, Y. G.; Hao, J.; Gao, X.; Xie, S. S.
刊名: TRANSPLANTATION PROCEEDINGS
发表日期: 2006-11-01
DOI: 10.1016/j.transproceed.2006.08.176
卷: 38, 期:9, 页:3043-3045
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology ; Surgery ; Transplantation
研究领域[WOS]: Immunology ; Surgery ; Transplantation
关键词[WOS]: DRUG-INDUCED TOLERANCE ; HEART-TRANSPLANTATION ; MICE
英文摘要:

There is a need to achieve donor-specific tolerance in clinical organ transplantation, where potential benefits remain overshadowed by chronic rejection and the side-efects of long-term immunosuppressive therapy. It is known that the mature immune system in mice can be reprogrammed to accept a foreign graft as if it was "self′. The AdCTIA4Ig-mediated gene transfer (SC) + cyclophosphamide (CP) treatment alone prolongs allograft survival but does not induce tolerance. However, in our study, the AdCTLA41g-mediated gene transfer combined with SC + CP treatment yielded significantly prolonged mean survival times (149.7 +/- 18.0 days), while those in the untreated or AdLacZ treated mice were rejected in normal fashion (5.3 +/- 0.5 and 5.2 +/- 0.4 days, respectively), and survival in the AdCTLA4Ig or SC + CP treated groups were 45.7 +/- 9.6 or 50.2 +/- 5.3 days, respectively. In conclusion, a protocol of AdCTLA4Ig + SC + CP improved the survival of DA -> LEW cardiac allografts.

语种: 英语
WOS记录号: WOS:000242294500076
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54345
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 100083, Peoples R China

Recommended Citation:
Wang, G. M.,Ma, J. B.,Jin, Y. Z.,et al. Long-term survival of cardiac allografts induced by cyclophosphamide combined with CTLA4Ig-gene transfer mediated by adenoviral vector[J]. TRANSPLANTATION PROCEEDINGS,2006,38(9):3043-3045.
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