IR@PKUHSC  > 北京大学基础医学院  > 免疫学系
学科主题基础医学
Long-term survival of cardiac allografts induced by cyclophosphamide combined with CTLA4Ig-gene transfer mediated by adenoviral vector
Wang, G. M.; Ma, J. B.; Jin, Y. Z.; Feng, Y. G.; Hao, J.; Gao, X.; Xie, S. S.
刊名TRANSPLANTATION PROCEEDINGS
2006-11-01
DOI10.1016/j.transproceed.2006.08.176
38期:9页:3043-3045
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology ; Surgery ; Transplantation
研究领域[WOS]Immunology ; Surgery ; Transplantation
关键词[WOS]DRUG-INDUCED TOLERANCE ; HEART-TRANSPLANTATION ; MICE
英文摘要

There is a need to achieve donor-specific tolerance in clinical organ transplantation, where potential benefits remain overshadowed by chronic rejection and the side-efects of long-term immunosuppressive therapy. It is known that the mature immune system in mice can be reprogrammed to accept a foreign graft as if it was "self′. The AdCTIA4Ig-mediated gene transfer (SC) + cyclophosphamide (CP) treatment alone prolongs allograft survival but does not induce tolerance. However, in our study, the AdCTLA41g-mediated gene transfer combined with SC + CP treatment yielded significantly prolonged mean survival times (149.7 +/- 18.0 days), while those in the untreated or AdLacZ treated mice were rejected in normal fashion (5.3 +/- 0.5 and 5.2 +/- 0.4 days, respectively), and survival in the AdCTLA4Ig or SC + CP treated groups were 45.7 +/- 9.6 or 50.2 +/- 5.3 days, respectively. In conclusion, a protocol of AdCTLA4Ig + SC + CP improved the survival of DA -> LEW cardiac allografts.

语种英语
WOS记录号WOS:000242294500076
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54345
Collection北京大学基础医学院_免疫学系
作者单位Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Wang, G. M.,Ma, J. B.,Jin, Y. Z.,et al. Long-term survival of cardiac allografts induced by cyclophosphamide combined with CTLA4Ig-gene transfer mediated by adenoviral vector[J]. TRANSPLANTATION PROCEEDINGS,2006,38(9):3043-3045.
APA Wang, G. M..,Ma, J. B..,Jin, Y. Z..,Feng, Y. G..,Hao, J..,...&Xie, S. S..(2006).Long-term survival of cardiac allografts induced by cyclophosphamide combined with CTLA4Ig-gene transfer mediated by adenoviral vector.TRANSPLANTATION PROCEEDINGS,38(9),3043-3045.
MLA Wang, G. M.,et al."Long-term survival of cardiac allografts induced by cyclophosphamide combined with CTLA4Ig-gene transfer mediated by adenoviral vector".TRANSPLANTATION PROCEEDINGS 38.9(2006):3043-3045.
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