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学科主题: 临床医学
题名:
Remission of rheumatoid arthritis and potential determinants: a national multi-center cross-sectional survey
作者: Wang, Guan-Ying1; Zhang, Sa-Li1; Wang, Xiu-Ru2; Feng, Min1; Li, Chun1; An, Yuan1; Li, Xiao-Feng3; Wang, Li-Zhi3; Wang, Cai-Hong3; Wang, Yong-Fu4; Yang, Rong4; Yan, Hui-Ming4; Wang, Guo-Chun5; Lu, Xin5; Liu, Xia5; Zhu, Ping6; Chen, Li-Na6; Jin, Hong-Tao7; Liu, Jin-Ting7; Guo, Hui-Fang7; Chen, Hai-Ying8; Xie, Jian-Li8; Wei, Ping8; Wang, Jun-Xiang8; Liu, Xiang-Yuan9; Sun, Lin9; Cui, Liu-Fu10; Shu, Rong10; Liu, Bai-Lu10; Yu, Ping10; Zhang, Zhuo-Li11; Li, Guang-Tao11; Li, Zhen-Bin12; Yang, Jing12; Li, Jun-Fang13; Jia, Bin13; Zhang, Feng-Xiao14; Tao, Jie-Mei14; Lin, Jin-Ying15; Wei, Mei-Qiu15; Liu, Xiao-Min16; Ke, Dan16; Hu, Shao-Xian17; Ye, Cong17; Han, Shu-Ling2; Yang, Xiu-Yan18; Li, Hao18; Huang, Ci-Bo19; Gao, Ming19; Lai, Bei19; Cheng, Yong-Jing19; Li, Xing-Fu20; Song, Li-Jun20; Yu, Xiao-Xia21; Wang, Ai-Xue22; Wu, Li-Jun22; Wang, Yan-Hua23; He, Lan23; Sun, Wen-Wen24; Gong, Lu24; Wang, Xiao-Yuan25; Wang, Yi25; Zhao, Yi26; Li, Xiao-Xia26; Wang, Yan27; Zhang, Yan28; Su, Yin1; Zhang, Chun-Fang29; Mu, Rong1; Li, Zhan-Guo1
关键词: Cross-sectional study ; Remission ; Rheumatoid arthritis ; Risk factors
刊名: CLINICAL RHEUMATOLOGY
发表日期: 2015-02-01
DOI: 10.1007/s10067-014-2828-3
卷: 34, 期:2, 页:221-230
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Rheumatology
研究领域[WOS]: Rheumatology
关键词[WOS]: DRUG-FREE REMISSION ; MODIFYING ANTIRHEUMATIC DRUGS ; RHEUMATOLOGY/EUROPEAN LEAGUE ; RADIOGRAPHIC PROGRESSION ; AMERICAN-COLLEGE ; OBSERVATIONAL COHORT ; CLINICAL REMISSION ; DEFINING REMISSION ; DISEASE-ACTIVITY ; FOLLOW-UP
英文摘要:

The aim of this study is to investigate the remission rate of rheumatoid arthritis (RA) in China and identify its potential determinants. A multi-center cross-sectional study was conducted from July 2009 to January 2012. Data were collected by face-to-face interviews of the rheumatology outpatients in 28 tertiary hospitals in China. The remission rates were calculated in 486 RA patients according to different definitions of remission: the Disease Activity Score in 28 joints (DAS28), the Simplified Disease Activity Index (SDAI), the Clinical Disease Activity Index (CDAI), and the American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) Boolean definition. Potential determinants of RA remission were assessed by univariate and multivariate analyses. The remission rates of RA from this multi-center cohort were 8.6 % (DAS28), 8.4 % (SDAI), 8.2 % (CDAI), and 6.8 % (Boolean), respectively. Favorable factors associated with remission were: low Health Assessment Questionnaire (HAQ) score, absence of rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP), and treatment of methotrexate (MTX) and hydroxychloroquine (HCQ). Younger age was also predictive for the DAS28 and the Boolean remission. Multivariate analyses revealed a low HAQ score, the absence of anti-CCP, and the treatment with HCQ as independent determinants of remission. The clinical remission rate of RA patients was low in China. A low HAQ score, the absence of anti-CCP, and HCQ were significant independent determinants for RA remission.

语种: 英语
所属项目编号: 2008BAI59B01 ; 2012ZX09104103
项目资助者: National Key Technology RD Program ; National Medical Science and Technique Foundation during the 12th Five-Year Plan Period
WOS记录号: WOS:000348803000006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54351
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Beijing Hosp, Dept Rheumatol & Immunol, Beijing, Peoples R China
2.Beijing Xuanwu Hosp, Dept Rheumatol & Immunol, Beijing, Peoples R China
3.Peking Univ, Dept Rheumatol & Immunol, Peoples Hosp, Beijing 100044, Peoples R China
4.Peking Univ, Dept Rheumatol & Immunol, Shougang Hosp, Beijing 100044, Peoples R China
5.Shanxi Med Univ, Dept Rheumatol & Immunol, Affiliated Hosp 2, Taiyuan, Shanxi, Peoples R China
6.Baotou Med Coll, Dept Rheumatol & Immunol, Affiliated Hosp 1, Baotou, Inner Mongolia, Peoples R China
7.China Japan Friendship Hosp, Dept Rheumatol, Beijing, Peoples R China
8.Fourth Mil Med Univ, Dept Rheumatol & Immunol, Xijing Hosp, Xian 710032, Shaanxi, Peoples R China
9.Hebei Med Univ, Dept Rheumatol & Immunol, Hosp 2, Shijiazhuang, Hebei, Peoples R China
10.Hebei Med Univ, Dept Rheumatol & Immunol, Hosp 3, Shijiazhuang, Hebei, Peoples R China
11.Peking Univ, Dept Rheumatol & Immunol, Hosp 3, Beijing 100044, Peoples R China
12.North China Coal Med Univ, Dept Rheumatol & Immunol, Affiliated Kailuan Hosp, Tangshan, Hebei, Peoples R China
13.Peking Univ, Dept Rheumatol & Immunol, Hosp 1, Beijing 100044, Peoples R China
14.Bethune Int Peace Hosp, Dept Rheumatol & Immunol, Shijiazhuang, Hebei, Peoples R China
15.Cent Hosp Handan City, Dept Rheumatol & Immunol, Handan, Hebei, Peoples R China
16.Hebei Peoples Hosp, Dept Rheumatol & Immunol, Shijiazhuang, Hebei, Peoples R China
17.Peoples Hosp Guangxi, Dept Rheumatol & Immunol, Nanning, Guangxi, Peoples R China
18.China Med Univ, Dept Rheumatol & Immunol, Beijing Shunyi Hosp, Beijing, Peoples R China
19.Huazhong Univ Sci & Technol, Dept Rheumatol, Tongji Hosp, Tongji Med Coll, Wuhan 430074, Hubei, Peoples R China
20.Sun Yat Sen Univ, Affiliated Hosp 1, Dept Rheumatol & Clin Immunol, Guangzhou 510275, Guangdong, Peoples R China
21.Shandong Univ, Dept Rheumatol, Qilu Hosp, Jinan, Shandong, Peoples R China
22.Cangzhou Hosp Integrated Tradit Chinese & Western, Dept Rheumatol & Immunol, Cangzhou, Hebei, Peoples R China
23.Peoples Hosp Xinjiang Uygur Autonomous Reg, Dept Rheumatol & Immunol, Urumqi, Xinjiang, Peoples R China
24.Xi An Jiao Tong Univ, Dept Rheumatol & Immunol, Affiliated Hosp 1, Xian 710049, Shaanxi, Peoples R China
25.Tianjin Med Univ, Dept Infect Dis & Rheumatol, Gen Hosp, Tianjin, Peoples R China
26.Lanzhou Univ, Dept Rheumatol, Hosp 2, Lanzhou 730000, Gansu, Peoples R China
27.Lanzhou Univ, Dept Rheumatol & Immunol, Affiliated Hosp 5, Lanzhou 730000, Gansu, Peoples R China
28.309th Hosp Chinese Peoples Liberat Army, Dept Rheumatol & Immunol, Beijing, Peoples R China
29.Peking Univ, Dept Clin Epidemiol, Peoples Hosp, Beijing 100044, Peoples R China

Recommended Citation:
Wang, Guan-Ying,Zhang, Sa-Li,Wang, Xiu-Ru,et al. Remission of rheumatoid arthritis and potential determinants: a national multi-center cross-sectional survey[J]. CLINICAL RHEUMATOLOGY,2015,34(2):221-230.
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