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Stereoselective synthesis and anti-inflammatory activities of 6-and 7-membered dioxacycloalkanes
Gu, KL; Bi, LR; Zhao, M; Wang, C; Dolan, C; Kao, MC; Tok, JBH; Peng, SQ
关键词Stereoselective Trans-acetalization 5-amino-dioxacycloalkanes Anti-inflammatory Activity
刊名BIOORGANIC & MEDICINAL CHEMISTRY
2006-03-01
DOI10.1016/j.bmc.2005.09.068
14期:5页:1339-1347
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry
关键词[WOS]PROTEIN-KINASE-C ; CONFORMATIONALLY CONSTRAINED ANALOGS ; TARGET ; DIACYLGLYCEROL ; INFLAMMATION ; PSORIASIS ; LACTONES ; THERAPY ; EPSILON ; CANCER
英文摘要

A class of 5-trifluoroacetylamino-1,3-dioxacycloalkanes, 5-benzoylamino-1,3-dioxacycloalkanes and 5-amino-1,3-dioxacycloalkane compounds were stereoselectively synthesized as potential anti-inflammatory drug candidates. The anti -inflammatory activities of these compounds were tested using the xylene-induced mouse ear edema model, from which multiple compounds possessing anti-inflammatory properties which surpass aspirin were identified; these compounds were then compared to establish structure-activity relationships. (c) 2005 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000235244400006
Citation statistics
Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54355
Collection北京大学药学院
作者单位1.Peking Univ, Coll Pharmaceut Sci, Beijing 100083, Peoples R China
2.Capital Univ Med Sci, Coll Pharmaceut Sci, Beijing 100054, Peoples R China
3.Lawrence Livermore Natl Lab, Chem & Mat Sci Directorate, Livermore, CA 94550 USA
Recommended Citation
GB/T 7714
Gu, KL,Bi, LR,Zhao, M,et al. Stereoselective synthesis and anti-inflammatory activities of 6-and 7-membered dioxacycloalkanes[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2006,14(5):1339-1347.
APA Gu, KL.,Bi, LR.,Zhao, M.,Wang, C.,Dolan, C.,...&Peng, SQ.(2006).Stereoselective synthesis and anti-inflammatory activities of 6-and 7-membered dioxacycloalkanes.BIOORGANIC & MEDICINAL CHEMISTRY,14(5),1339-1347.
MLA Gu, KL,et al."Stereoselective synthesis and anti-inflammatory activities of 6-and 7-membered dioxacycloalkanes".BIOORGANIC & MEDICINAL CHEMISTRY 14.5(2006):1339-1347.
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