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Changes in the androgen levels in the ventral prostate of spontaneously hypertensive rats after castration
Hu, Mingqiu4; Xin, Dianqi4; Chen, Jun2; Sun, Guofeng3; Wang, Yiming2; Na, Yanqun1,4
关键词Castration Androgen Prostate Rat
刊名BJU INTERNATIONAL
2009-08-01
DOI10.1111/j.1464-410X.2009.08442.x
104期:3页:406-411
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]DEPRIVATION THERAPY ; C-19 STEROIDS ; GUINEA-PIG ; CANCER ; TISSUE ; DIHYDROTESTOSTERONE ; RECURRENT ; DEHYDROEPIANDROSTERONE ; ANDROSTENEDIONE ; TESTOSTERONE
英文摘要

OBJECTIVE

To characterize the changes in androgen levels in the prostate after castration, as androgens are critical in the progression of prostate cancer after castration, but the time at which the androgen remaining in the prostatic cancer tissue after castration exerts its effects is poorly understood.

MATERIALS AND METHODS

The ventral prostate (VP) in adult male spontaneously hypertensive rats was excised at 2, 4 and 8 h, 1, 2, 4 and 7 days, and 2, 4 and 8 weeks after castration. The dihydrotestosterone (DHT), testosterone, dehydroepiandrosterone (DHEA) and androstenedione (4-dione) levels in the VP were measured simultaneously using gas chromatography/tandem mass spectrometry.

RESULTS

Within 2 days of castration, the DHT and testosterone levels in the VP decreased sharply, while there were no significant changes in the DHEA or 4-dione levels. From 2 days to 2 weeks after castration (2-7 days for 4-dione), there was a sharp peak in tissue androgen levels in the VP (P < 0.05 for all androgens); during the subsequent 6 weeks after castration, all of the tissue DHT, testosterone, DHEA and 4-dione levels gradually increased with time.

CONCLUSIONS

These data show the changes which occur in androgen levels in rat VP after castration and support the concept that the adrenal glands compensate for the loss of testicular androgen.

语种英语
WOS记录号WOS:000267879900025
项目编号30772169
资助机构National Nature Science Foundation of China
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54360
专题北京大学第一临床医学院_泌尿外科
北京大学基础医学院
作者单位1.Peking Univ, Inst Urol, Beijing 100871, Peoples R China
2.Peking Univ, Hosp 1, Dept Urol, Inst Urol, Beijing 100034, Peoples R China
3.Tsinghua Univ, Dept Biosci & Technol, Beijing 100084, Peoples R China
4.Peking Univ, Shougang Hosp, Dept Urol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Hu, Mingqiu,Xin, Dianqi,Chen, Jun,et al. Changes in the androgen levels in the ventral prostate of spontaneously hypertensive rats after castration[J]. BJU INTERNATIONAL,2009,104(3):406-411.
APA Hu, Mingqiu,Xin, Dianqi,Chen, Jun,Sun, Guofeng,Wang, Yiming,&Na, Yanqun.(2009).Changes in the androgen levels in the ventral prostate of spontaneously hypertensive rats after castration.BJU INTERNATIONAL,104(3),406-411.
MLA Hu, Mingqiu,et al."Changes in the androgen levels in the ventral prostate of spontaneously hypertensive rats after castration".BJU INTERNATIONAL 104.3(2009):406-411.
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