|Changes in the androgen levels in the ventral prostate of spontaneously hypertensive rats after castration|
|Hu, Mingqiu4; Xin, Dianqi4; Chen, Jun2; Sun, Guofeng3; Wang, Yiming2; Na, Yanqun1,4|
|关键词||Castration Androgen Prostate Rat|
|WOS标题词||Science & Technology|
|类目[WOS]||Urology & Nephrology|
|研究领域[WOS]||Urology & Nephrology|
|关键词[WOS]||DEPRIVATION THERAPY ; C-19 STEROIDS ; GUINEA-PIG ; CANCER ; TISSUE ; DIHYDROTESTOSTERONE ; RECURRENT ; DEHYDROEPIANDROSTERONE ; ANDROSTENEDIONE ; TESTOSTERONE|
To characterize the changes in androgen levels in the prostate after castration, as androgens are critical in the progression of prostate cancer after castration, but the time at which the androgen remaining in the prostatic cancer tissue after castration exerts its effects is poorly understood.
MATERIALS AND METHODS
The ventral prostate (VP) in adult male spontaneously hypertensive rats was excised at 2, 4 and 8 h, 1, 2, 4 and 7 days, and 2, 4 and 8 weeks after castration. The dihydrotestosterone (DHT), testosterone, dehydroepiandrosterone (DHEA) and androstenedione (4-dione) levels in the VP were measured simultaneously using gas chromatography/tandem mass spectrometry.
Within 2 days of castration, the DHT and testosterone levels in the VP decreased sharply, while there were no significant changes in the DHEA or 4-dione levels. From 2 days to 2 weeks after castration (2-7 days for 4-dione), there was a sharp peak in tissue androgen levels in the VP (P < 0.05 for all androgens); during the subsequent 6 weeks after castration, all of the tissue DHT, testosterone, DHEA and 4-dione levels gradually increased with time.
These data show the changes which occur in androgen levels in rat VP after castration and support the concept that the adrenal glands compensate for the loss of testicular androgen.
|资助机构||National Nature Science Foundation of China|
|作者单位||1.Peking Univ, Inst Urol, Beijing 100871, Peoples R China|
2.Peking Univ, Hosp 1, Dept Urol, Inst Urol, Beijing 100034, Peoples R China
3.Tsinghua Univ, Dept Biosci & Technol, Beijing 100084, Peoples R China
4.Peking Univ, Shougang Hosp, Dept Urol, Beijing 100871, Peoples R China
|Hu, Mingqiu,Xin, Dianqi,Chen, Jun,et al. Changes in the androgen levels in the ventral prostate of spontaneously hypertensive rats after castration[J]. BJU INTERNATIONAL,2009,104(3):406-411.|
|APA||Hu, Mingqiu,Xin, Dianqi,Chen, Jun,Sun, Guofeng,Wang, Yiming,&Na, Yanqun.(2009).Changes in the androgen levels in the ventral prostate of spontaneously hypertensive rats after castration.BJU INTERNATIONAL,104(3),406-411.|
|MLA||Hu, Mingqiu,et al."Changes in the androgen levels in the ventral prostate of spontaneously hypertensive rats after castration".BJU INTERNATIONAL 104.3(2009):406-411.|
|Changes in the andro（228KB）||期刊论文||出版稿||开放获取||CC BY-NC-SA||浏览 请求全文|