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学科主题: 临床医学
题名:
Changes in the androgen levels in the ventral prostate of spontaneously hypertensive rats after castration
作者: Hu, Mingqiu4; Xin, Dianqi4; Chen, Jun2; Sun, Guofeng3; Wang, Yiming2; Na, Yanqun1,4
关键词: castration ; androgen ; prostate ; rat
刊名: BJU INTERNATIONAL
发表日期: 2009-08-01
DOI: 10.1111/j.1464-410X.2009.08442.x
卷: 104, 期:3, 页:406-411
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: DEPRIVATION THERAPY ; C-19 STEROIDS ; GUINEA-PIG ; CANCER ; TISSUE ; DIHYDROTESTOSTERONE ; RECURRENT ; DEHYDROEPIANDROSTERONE ; ANDROSTENEDIONE ; TESTOSTERONE
英文摘要:

OBJECTIVE

To characterize the changes in androgen levels in the prostate after castration, as androgens are critical in the progression of prostate cancer after castration, but the time at which the androgen remaining in the prostatic cancer tissue after castration exerts its effects is poorly understood.

MATERIALS AND METHODS

The ventral prostate (VP) in adult male spontaneously hypertensive rats was excised at 2, 4 and 8 h, 1, 2, 4 and 7 days, and 2, 4 and 8 weeks after castration. The dihydrotestosterone (DHT), testosterone, dehydroepiandrosterone (DHEA) and androstenedione (4-dione) levels in the VP were measured simultaneously using gas chromatography/tandem mass spectrometry.

RESULTS

Within 2 days of castration, the DHT and testosterone levels in the VP decreased sharply, while there were no significant changes in the DHEA or 4-dione levels. From 2 days to 2 weeks after castration (2-7 days for 4-dione), there was a sharp peak in tissue androgen levels in the VP (P < 0.05 for all androgens); during the subsequent 6 weeks after castration, all of the tissue DHT, testosterone, DHEA and 4-dione levels gradually increased with time.

CONCLUSIONS

These data show the changes which occur in androgen levels in rat VP after castration and support the concept that the adrenal glands compensate for the loss of testicular androgen.

语种: 英语
所属项目编号: 30772169
项目资助者: National Nature Science Foundation of China
WOS记录号: WOS:000267879900025
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54360
Appears in Collections:北京大学第一临床医学院_泌尿外科_期刊论文

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作者单位: 1.Peking Univ, Inst Urol, Beijing 100871, Peoples R China
2.Peking Univ, Hosp 1, Dept Urol, Inst Urol, Beijing 100034, Peoples R China
3.Tsinghua Univ, Dept Biosci & Technol, Beijing 100084, Peoples R China
4.Peking Univ, Shougang Hosp, Dept Urol, Beijing 100871, Peoples R China

Recommended Citation:
Hu, Mingqiu,Xin, Dianqi,Chen, Jun,et al. Changes in the androgen levels in the ventral prostate of spontaneously hypertensive rats after castration[J]. BJU INTERNATIONAL,2009,104(3):406-411.
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