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Efficacy of low-dose tamsulosin in chinese patients with symptomatic benign prostatic hyperplasia
Li, NC; Chen, S; Yang, XH; Du, LD; Wang, JY; Na, YQ; Beijing Tamsulosin Study Grp
刊名CLINICAL DRUG INVESTIGATION
2003
23期:12页:781-787
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]ANTAGONISTS ; TERAZOSIN
英文摘要

Objective: To determine the efficacy and tolerability of low-dose tamsulosin 0.2 mg/day in Chinese patients with symptomatic benign prostatic hyperplasia (BPH).

Methods: A total of 505 patients were enrolled in a 6-week nonblind, multicentre study, and 499 patients were followed for the entire 6-week treatment period. After a 2-week washout period, patients with confirmed symptomatic BPH were treated with tamsulosin 0.2mg daily. International Prostate Symptom Score (I-PSS), quality-of-life (QOL) index, maximum urinary flow rate (Q(max)) and average urinary flow rate (Q(ave)) were the efficacy parameters. Adverse events and variations in blood pressure and heart rate were also monitored.

Results: Total I-PSS and QOL index scores were improved from baseline with an average score reduction of 7.50 and 1.40, respectively (p < 0.01). Mean Q(max) and Q(ave) were increased by an average of 4.33 mL/sec (p < 0.01) and 2.04 mL/sec, respectively (p < 0.01). A subgroup analysis showed that total I-PSS, QOL index and Q(max) were significantly improved irrespective of baseline I-PSS, age, duration of BPH, comorbid conditions, or the use of concomitant antihypertensive agents. A positive correlation was noted between improvement in total I-PSS and QOL index (r = 0.70). Relative to baseline, systolic and diastolic blood pressure decreased by a mean of 3.35mm Hg and 2.74mm Hg, respectively (p < 0.01). A total of 28 treatment-related adverse reactions were reported in 24 patients (4.75%), the majority of which were mild dizziness and headache.

Conclusions: Low-dose tamsulosin 0.2 mg/day has a favourable efficacy and tolerability profile in Chinese patients with symptomatic BPH irrespective of the baseline characteristics of these patients. No serious, unexpected adverse effects were identified.

语种英语
WOS记录号WOS:000187585900003
引用统计
被引频次:28[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54363
专题北京大学第一临床医学院_泌尿外科
作者单位1.Peking Univ, Hosp 1, Inst Urol, Beijing 100034, Peoples R China
2.Beijing Ton Ren Hosp, Dept Urol, Beijing, Peoples R China
3.Gen Hosp, Beijing Mil Reg, Dept Urol, Beijing, Peoples R China
4.Beijing Hosp, Dept Urol, Beijing, Peoples R China
5.Beijing Friendship Hosp, Dept Urol, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Li, NC,Chen, S,Yang, XH,et al. Efficacy of low-dose tamsulosin in chinese patients with symptomatic benign prostatic hyperplasia[J]. CLINICAL DRUG INVESTIGATION,2003,23(12):781-787.
APA Li, NC.,Chen, S.,Yang, XH.,Du, LD.,Wang, JY.,...&Beijing Tamsulosin Study Grp.(2003).Efficacy of low-dose tamsulosin in chinese patients with symptomatic benign prostatic hyperplasia.CLINICAL DRUG INVESTIGATION,23(12),781-787.
MLA Li, NC,et al."Efficacy of low-dose tamsulosin in chinese patients with symptomatic benign prostatic hyperplasia".CLINICAL DRUG INVESTIGATION 23.12(2003):781-787.
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