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学科主题: 临床医学
题名:
Efficacy of low-dose tamsulosin in chinese patients with symptomatic benign prostatic hyperplasia
作者: Li, NC; Chen, S; Yang, XH; Du, LD; Wang, JY; Na, YQ; Beijing Tamsulosin Study Grp
刊名: CLINICAL DRUG INVESTIGATION
发表日期: 2003
卷: 23, 期:12, 页:781-787
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: ANTAGONISTS ; TERAZOSIN
英文摘要:

Objective: To determine the efficacy and tolerability of low-dose tamsulosin 0.2 mg/day in Chinese patients with symptomatic benign prostatic hyperplasia (BPH).

Methods: A total of 505 patients were enrolled in a 6-week nonblind, multicentre study, and 499 patients were followed for the entire 6-week treatment period. After a 2-week washout period, patients with confirmed symptomatic BPH were treated with tamsulosin 0.2mg daily. International Prostate Symptom Score (I-PSS), quality-of-life (QOL) index, maximum urinary flow rate (Q(max)) and average urinary flow rate (Q(ave)) were the efficacy parameters. Adverse events and variations in blood pressure and heart rate were also monitored.

Results: Total I-PSS and QOL index scores were improved from baseline with an average score reduction of 7.50 and 1.40, respectively (p < 0.01). Mean Q(max) and Q(ave) were increased by an average of 4.33 mL/sec (p < 0.01) and 2.04 mL/sec, respectively (p < 0.01). A subgroup analysis showed that total I-PSS, QOL index and Q(max) were significantly improved irrespective of baseline I-PSS, age, duration of BPH, comorbid conditions, or the use of concomitant antihypertensive agents. A positive correlation was noted between improvement in total I-PSS and QOL index (r = 0.70). Relative to baseline, systolic and diastolic blood pressure decreased by a mean of 3.35mm Hg and 2.74mm Hg, respectively (p < 0.01). A total of 28 treatment-related adverse reactions were reported in 24 patients (4.75%), the majority of which were mild dizziness and headache.

Conclusions: Low-dose tamsulosin 0.2 mg/day has a favourable efficacy and tolerability profile in Chinese patients with symptomatic BPH irrespective of the baseline characteristics of these patients. No serious, unexpected adverse effects were identified.

语种: 英语
WOS记录号: WOS:000187585900003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54363
Appears in Collections:北京大学第一临床医学院_泌尿外科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Inst Urol, Beijing 100034, Peoples R China
2.Beijing Ton Ren Hosp, Dept Urol, Beijing, Peoples R China
3.Gen Hosp, Beijing Mil Reg, Dept Urol, Beijing, Peoples R China
4.Beijing Hosp, Dept Urol, Beijing, Peoples R China
5.Beijing Friendship Hosp, Dept Urol, Beijing, Peoples R China

Recommended Citation:
Li, NC,Chen, S,Yang, XH,et al. Efficacy of low-dose tamsulosin in chinese patients with symptomatic benign prostatic hyperplasia[J]. CLINICAL DRUG INVESTIGATION,2003,23(12):781-787.
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