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学科主题: 临床医学
题名:
Analysis of the clinical efficacy of intravitreal bevacizumab in the treatment of iris neovascularization caused by proliferative diabetic retinopathy
作者: Jiang, Yanrong; Liang, Xiaoying; Li, Xiaoxin; Tao, Yong; Wang, Kai
关键词: Avastin ; clinical efficacy ; intravitreal bevacizumab ; iris neovascularization ; proliferative diabetic retinopathy ; vascular endothelial growth factor ; VEGF antibody
刊名: ACTA OPHTHALMOLOGICA
发表日期: 2009-11-01
DOI: 10.1111/j.1755-3768.2008.01353.x
卷: 87, 期:7, 页:736-740
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Ophthalmology
研究领域[WOS]: Ophthalmology
关键词[WOS]: ENDOTHELIAL GROWTH-FACTOR ; VASCULAR-PERMEABILITY FACTOR ; MONOCLONAL-ANTIBODY ; RUBEOSIS IRIDIS ; CELLS SECRETE ; AVASTIN ; THERAPY
英文摘要:

Purpose:

To evaluate the therapeutic effect of intravitreal bevacizumab (Avastin (R)) (IVB) in the treatment of iris neovascularization (INV) in proliferative diabetic retinopathy (PDR).

Methods:

A retrospective analysis on data collected from 28 eyes of 22 patients with PDR was performed. The analysis included grading of INV, visual acuity (VA) and intraocular pressure (IOP) prior to and after IVB treatment.

Results:

Significant regression was noted in 20 eyes (71.4%); six eyes (21.4%) showed partial regression; no change or worsening was observed in two eyes (7.2%). VA (measured with a Snellen acuity chart) improved in five eyes (17.9%) while the remaining 23 eyes (82.1%) had no improvement. In the 11 eyes with preoperative neovascular glaucoma, IOP decreased in 10 eyes (91%) and increased in one eye (9%) after treatment.

Conclusion:

IVB treatment of INV in PDR patients shows a promising short-term result. Further studies are needed to evaluate long-term results.

语种: 英语
所属项目编号: 7062065 ; 2005CB724307 ; RDB2007-46
项目资助者: Beijing Natural Science Foundation ; National Basic Research Program of China (973 Program) ; Fund of the People&prime ; s Hospital of Peking University
WOS记录号: WOS:000270999300008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54371
Appears in Collections:北京大学第二临床医学院_眼科_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Dept Ophthalmol, Beijing 100871, Peoples R China

Recommended Citation:
Jiang, Yanrong,Liang, Xiaoying,Li, Xiaoxin,et al. Analysis of the clinical efficacy of intravitreal bevacizumab in the treatment of iris neovascularization caused by proliferative diabetic retinopathy[J]. ACTA OPHTHALMOLOGICA,2009,87(7):736-740.
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