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学科主题: 药学
题名:
Dioxyxanthones from Polygala hongkongensis and Their Cytotoxicity
作者: Wu Jian-feng1; Tu Peng-fei2; Zhan Hai-tao1; Gao Jing-chun3
关键词: Polygala hongkongensis ; Polygalaceae ; Dioxyxanthone ; Polyhongkongenoxanthone A and B ; Cytotoxicity
刊名: CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
发表日期: 2011-09-01
卷: 27, 期:5, 页:777-779
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: TENUIFOLIA WILLDENOW ; XANTHONE GLYCOSIDES ; ROOTS ; ANTIOXIDANTS ; ESTERS ; HEMSL ; ACID
英文摘要:

Two new dioxyxanthones, polyhongkongenoxanthones A and B(1 and 2) were isolated from the herbs of Polygala hongkongensis, together with six known xanthones. Their structures were elucidated on the basis of chemical and spectroscopic evidence. The isolates were tested for their cytotoxicity against three tumor cell lines(HepG2, GLC-82 and MCF-7, HepG2=human hepatocellular carcinoma cells; GLC-82=human lung carcinoma cells; MCF-7= human breast carcinoma cells) by MTT assay, among which polyhongkongenoxanthone 13(2), 1,7-dihydroxy-2,3-methylenedioxyxanthone(3) and 1,7-dihydroxy-3,4,8-trimethoxyxanthone(6) are potential antitumor candidate due to their significant cytotoxic effects on the three cell lines.

语种: 英语
所属项目编号: 9151064201000042
项目资助者: Natural Science Foundation of Guangdong Province, China
WOS记录号: WOS:000296120800014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54373
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Foshan Univ, Coll Med, Foshan 528000, Peoples R China
2.Peking Univ, Hlth Sci Ctr, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
3.City Univ Hongkong, Dept Biol & Chem, Hong Kong, Hong Kong, Peoples R China

Recommended Citation:
Wu Jian-feng,Tu Peng-fei,Zhan Hai-tao,et al. Dioxyxanthones from Polygala hongkongensis and Their Cytotoxicity[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2011,27(5):777-779.
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