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IR@PKUHSC  > 北京大学口腔医学院  > 口腔病理科  > 期刊论文
学科主题: 口腔医学
题名:
Expression of ghrelin in human salivary glands and its levels in saliva and serum in Chinese obese children and adolescents
作者: Li, Bin-Bin5; Chen, Zhi-Bin4; Li, Bo-Chun3; Lin, Qin2; Li, Xiao-Xin2; Li, Sheng-Lin3; Ding, Chong1; Wu, Li-Ling1; Yu, Guang-Yan3
关键词: Ghrelin ; Saliva ; Children ; Obesity
刊名: ARCHIVES OF ORAL BIOLOGY
发表日期: 2011-04-01
DOI: 10.1016/j.archoralbio.2010.10.014
卷: 56, 期:4, 页:389-394
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dentistry, Oral Surgery & Medicine
研究领域[WOS]: Dentistry, Oral Surgery & Medicine
关键词[WOS]: PLASMA GHRELIN ; ACYLATED PEPTIDE ; FOOD-INTAKE ; BODY-MASS ; GLUCOSE ; RATS
英文摘要:

Objective: The aim of the present study was to reveal the expression characteristics of ghrelin in human three major salivary glands and to investigate saliva and serum ghrelin level and the relation with weight and lipid indices in Chinese children.

Design: Expression and distribution of ghrelin in parotid, submandibular, and sublingual glands were measured by reverse transcription-polymerase chain reaction and immunohistochemistry. Saliva and serum samples were collected from 194 Chinese children and adolescents (mean age 12.98 years). Ghrelin levels were tested by enzyme-linked immunosorbent assay. Significant differences were estimated by one-way ANOVA.

Results: Ghrelin mRNA was expressed in parotid and submandibular glands, but was not detectable in sublingual glands. Ghrelin proteins were widespread in the cytoplasm of striated, intercalated and excretory ducts, as well as in serous acini of parotid and submandibular glands, but not in mucous acinar cells of sublingual glands. Saliva and serum ghrelin levels were increased along with BMI. There was positive correlation between saliva and serum ghrelin levels (r = 0.534, P < 0.01). Serum and saliva ghrelin levels were both significantly correlated with BMI (r = 0.523, r = 0.374, P < 0.01, respectively), but not with blood lipid levels.

Conclusions: Parotid and submandibular glands were primary sources of ghrelin produced and released in saliva. Although whether salivary ghrelin could be useful in the diagnosis of obesity remains to be determined, salivary ghrelin might be a possible alternative to serum ghrelin for predicting obesity. (C) 2010 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 30370102 ; 20050001113
项目资助者: National Natural Science Foundation of China ; Ministry of Education
WOS记录号: WOS:000289608800012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54374
Appears in Collections:北京大学口腔医学院_口腔病理科_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100191, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Clin Lab, Beijing 100871, Peoples R China
3.Peking Univ, Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China
4.Peking Univ, Sch & Hosp Stomatol, Dept Periodont, Beijing 100871, Peoples R China
5.Peking Univ, Sch & Hosp Stomatol, Dept Oral Pathol, Beijing 100871, Peoples R China

Recommended Citation:
Li, Bin-Bin,Chen, Zhi-Bin,Li, Bo-Chun,et al. Expression of ghrelin in human salivary glands and its levels in saliva and serum in Chinese obese children and adolescents[J]. ARCHIVES OF ORAL BIOLOGY,2011,56(4):389-394.
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