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学科主题: 临床医学
题名:
Bacterial vaginosis is conducive to the persistence of HPV infection
作者: Guo, Y-I1; You, K.1; Qiao, J.1; Zhao, Y-M2; Geng, L.1
关键词: human papillomavirus ; HPV ; bacterial vaginosis ; BV ; persistence ; high-risk HPV ; follow-up
刊名: INTERNATIONAL JOURNAL OF STD & AIDS
发表日期: 2012-08-01
DOI: 10.1258/ijsa.2012.011342
卷: 23, 期:8, 页:581-584
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology ; Infectious Diseases
研究领域[WOS]: Immunology ; Infectious Diseases
关键词[WOS]: HUMAN-PAPILLOMAVIRUS INFECTION ; NATURAL-HISTORY ; CERVICAL-CANCER ; WOMEN ; DIAGNOSIS ; METAANALYSIS ; NEOPLASIA ; SMEARS ; CELLS
英文摘要:

We investigated the effects of bacterial vaginosis (BV) on the outcomes of high-risk human papillomavirus infection (HR-HPV). BV was diagnosed on Papanicolaou-stained cytology slides of 707 HPV-positive patients. HR-HPV DNA expression was analysed using the Hybrid Capture II (HC-II) assay. Of the 707 HR-HPV-positive female patients, 298 (42.1%) exhibited clearance of HR-HPV. The remaining 409 patients had persistent HR-HPV infection. The persistent HR-HPV group and the clearing group had similar rates of BV at the beginning of the study. At the end of the study, the persistent HR-HPV group had a BV prevalence of 11.2% while the clearing group had a significant lower BV prevalence of 5.0%. A decreased clearance of HPV was found in women with current BV, compared with women without BV. Furthermore, the natural history of HPV was not affected by the HPV viral load or the BV prevalence at the beginning of the study (P>0.05). Bacterial vaginosis appears conducive to the persistence of HPV infection.

语种: 英语
WOS记录号: WOS:000309297400010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54380
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Obstet & Gynecol, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Res Ctr Clin Epidemiol, Beijing 100191, Peoples R China

Recommended Citation:
Guo, Y-I,You, K.,Qiao, J.,et al. Bacterial vaginosis is conducive to the persistence of HPV infection[J]. INTERNATIONAL JOURNAL OF STD & AIDS,2012,23(8):581-584.
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