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学科主题: 药学
题名:
A Biomimetic Chitosan Derivates: Preparation, Characterization and Transdermal Enhancement Studies of N-Arginine Chitosan
作者: Lv, Hui-Xia2; Zhang, Zhen-Hai3; Wang, Xiao-Pan2; Cheng, Qing-Qing2; Wang, Wei2; Huang, Xu-Hui1; Zhou, Jian-Ping2; Zhang, Qiang4; Hou, Lu-Lu5; Huo, Wei5
关键词: biomimetic chitosan derivates ; arginine-rich ; cell penetration peptides ; N-arginine chitosan ; transdermal enhancer ; adefovir
刊名: MOLECULES
发表日期: 2011-08-01
DOI: 10.3390/molecules16086778
卷: 16, 期:8, 页:6778-6790
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: NONLINEAR-OPTICAL CRYSTAL ; DELIVERY ; NANOPARTICLES ; PEPTIDES ; ADEFOVIR ; CELL ; PH
英文摘要:

A novel arginine-rich chitosan (CS) derivates mimicked cell penetration peptides; N-Arginine chitosan (N-Arg-CS) was prepared by two reaction methods involving activated L-arginine and the amine group on the chitosan. FTIR spectra showed that arginine was chemically coupled with CS. Elemental analysis estimated that the degrees of substitution (DS) of arginine in CS were 6%, 31.3% and 61.5%, respectively. The drug adefovir was chosen as model and its permeation flux across excised mice skin was investigated using a Franz diffusion cell. The results showed that the most effective enhancer was 2% (w/v) concentration of 10 kDa N-Arg-CS with 6% DS. At neutral pH, the cumulative amount of adefovir permeated after 12 hours was 2.63 +/- 0.19 mg cm(-2) which was 5.83-fold more than adefovir aqueous solution. Meanwhile N-Arg-CS was 1.83, 2.22, and 2.45 times more effective than Azone, eucalyptus and peppermint, respectively. The obtained results suggest that N-Arg-CS could be a promising transdermal enhancer.

语种: 英语
所属项目编号: 30901867 ; 30973649 ; 2009CB903300
项目资助者: National Natural Science Foundation of China ; National Basic Research Program of China (973 Program)
WOS记录号: WOS:000294249100048
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54381
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Fujian Prov Hosp, Dept Pharm, Fuzhou, Peoples R China
2.Jiangsu Prov Acad Tradit Chinese Med, Nanjing, Peoples R China
3.China Pharmaceut Univ, Dept Pharmaceut, Nanjing 210009, Peoples R China
4.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China
5.Jiangxi Xierkangtai Pharmaceut Co Ltd, Pingxiang, Jiangxi, Peoples R China

Recommended Citation:
Lv, Hui-Xia,Zhang, Zhen-Hai,Wang, Xiao-Pan,et al. A Biomimetic Chitosan Derivates: Preparation, Characterization and Transdermal Enhancement Studies of N-Arginine Chitosan[J]. MOLECULES,2011,16(8):6778-6790.
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