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学科主题: 基础医学
题名:
Human TMEM174 that is highly expressed in kidney tissue activates AP-1 and promotes cell proliferation
作者: Wang, Pingzhang1,2,3; Sun, Bo4; Hao, Dongxia4; Zhang, Xiujun4; Shi, Taiping1,2,3; Ma, Dalong1,2,3
关键词: AP-1 ; ELK1 ; TMEM174 ; Kidney ; Cell proliferation
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2010-04-16
DOI: 10.1016/j.bbrc.2010.03.109
卷: 394, 期:4, 页:993-999
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: MAP KINASE ; RENAL DEVELOPMENT ; C-FOS ; PATHWAY ; PHOSPHORYLATION ; IDENTIFICATION ; SUBUNITS ; SURVIVAL ; DISEASE ; ERK
英文摘要:

Mitogen-activated protein kinase (MAPK) cascades play an important role in regulation of AP-1 activity through the phosphorylation of distinct substrates. In the present study, we identified a novel protein, TMEM174, whose RNA transcripts are highly expressed in human kidney tissue. TMEM174 is comprised of 243 amino acids, and contains two predicted transmembrane helices which determine its subcellular localization in endoplasmic reticulum and influences its functions. Over-expression of TMME174 enhanced the transcriptional activity of AP-1 and promoted cell proliferation, whereas the truncated mutant TMEM174 Delta TM without the transmembrane regions did not retails these functions. The possible mechanism of activation of AP-1 by TMEM174 was further examined. Our results suggest the potential role of TMEM174 in renal development and physiological function. (C) 2010 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 2006AA02A305 ; 2009ZX09503-004
项目资助者: National High Technology Research and Development Program (863 Program) of China ; Key National S& ; T Program "Major New Drug Development"
WOS记录号: WOS:000276986400023
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54386
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: 1.Chinese Natl Human Genome Ctr, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Lab Med Immunol, Beijing 100191, Peoples R China
3.Peking Univ, Ctr Human Dis Genom, Beijing 100191, Peoples R China
4.Northchina Coal Med Coll, Dept Biol, Tangshan 063000, Peoples R China

Recommended Citation:
Wang, Pingzhang,Sun, Bo,Hao, Dongxia,et al. Human TMEM174 that is highly expressed in kidney tissue activates AP-1 and promotes cell proliferation[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2010,394(4):993-999.
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