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学科主题基础医学
Human TMEM174 that is highly expressed in kidney tissue activates AP-1 and promotes cell proliferation
Wang, Pingzhang1,2,3; Sun, Bo4; Hao, Dongxia4; Zhang, Xiujun4; Shi, Taiping1,2,3; Ma, Dalong1,2,3
关键词AP-1 ELK1 TMEM174 Kidney Cell proliferation
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2010-04-16
DOI10.1016/j.bbrc.2010.03.109
394期:4页:993-999
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]MAP KINASE ; RENAL DEVELOPMENT ; C-FOS ; PATHWAY ; PHOSPHORYLATION ; IDENTIFICATION ; SUBUNITS ; SURVIVAL ; DISEASE ; ERK
英文摘要

Mitogen-activated protein kinase (MAPK) cascades play an important role in regulation of AP-1 activity through the phosphorylation of distinct substrates. In the present study, we identified a novel protein, TMEM174, whose RNA transcripts are highly expressed in human kidney tissue. TMEM174 is comprised of 243 amino acids, and contains two predicted transmembrane helices which determine its subcellular localization in endoplasmic reticulum and influences its functions. Over-expression of TMME174 enhanced the transcriptional activity of AP-1 and promoted cell proliferation, whereas the truncated mutant TMEM174 Delta TM without the transmembrane regions did not retails these functions. The possible mechanism of activation of AP-1 by TMEM174 was further examined. Our results suggest the potential role of TMEM174 in renal development and physiological function. (C) 2010 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000276986400023
项目编号2006AA02A305 ; 2009ZX09503-004
资助机构National High Technology Research and Development Program (863 Program) of China ; Key National S& ; T Program "Major New Drug Development"
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54386
专题北京大学基础医学院_免疫学系
北京大学基础医学院
作者单位1.Chinese Natl Human Genome Ctr, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Lab Med Immunol, Beijing 100191, Peoples R China
3.Peking Univ, Ctr Human Dis Genom, Beijing 100191, Peoples R China
4.Northchina Coal Med Coll, Dept Biol, Tangshan 063000, Peoples R China
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GB/T 7714
Wang, Pingzhang,Sun, Bo,Hao, Dongxia,et al. Human TMEM174 that is highly expressed in kidney tissue activates AP-1 and promotes cell proliferation[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2010,394(4):993-999.
APA Wang, Pingzhang,Sun, Bo,Hao, Dongxia,Zhang, Xiujun,Shi, Taiping,&Ma, Dalong.(2010).Human TMEM174 that is highly expressed in kidney tissue activates AP-1 and promotes cell proliferation.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,394(4),993-999.
MLA Wang, Pingzhang,et al."Human TMEM174 that is highly expressed in kidney tissue activates AP-1 and promotes cell proliferation".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 394.4(2010):993-999.
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