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学科主题: 精神卫生
题名:
Cognitive-behavioural therapy for patients with schizophrenia: a multicentre randomized controlled trial in Beijing, China
作者: Li, Z. -J.1,2; Guo, Z. -H.1,2; Wang, N.1,2; Xu, Z. -Y.1,2; Qu, Y.3; Wang, X. -Q.4; Sun, J.5,6; Yan, L. -Q.7; Ng, R. M. K.8; Turkington, D.9; Kingdon, D.10
关键词: Cognitive-behavioural therapy ; randomized controlled trials ; schizophrenia ; supportive therapy
刊名: PSYCHOLOGICAL MEDICINE
发表日期: 2015-07-01
DOI: 10.1017/S0033291714002992
卷: 45, 期:9, 页:1893-1905
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Social Sciences ; Science & Technology
类目[WOS]: Psychology, Clinical ; Psychiatry ; Psychology
研究领域[WOS]: Psychology ; Psychiatry
关键词[WOS]: ORAL ANTIPSYCHOTICS ; SUPPORTIVE THERAPY ; PSYCHOSIS ; SYMPTOMS ; PANSS ; METAANALYSIS ; RELIABILITY ; MEDICATION ; RESISTANT ; EFFICACY
英文摘要:

Background. Meta-analyses support the efficacy of cognitive-behavioural therapy (CBT) for schizophrenia in western cultures. This study aimed to compare the efficacy of CBT and supportive therapy (ST) for patients with schizophrenia in China.

Method. A multicentre randomized controlled, single-blinded, parallel-group trial enrolled a sample of 192 patients with schizophrenia. All patients were offered 15 sessions of either CBT or ST over 24 weeks and followed up for an additional 60 weeks. All measures used were standardized instruments with good reliability and validity. The Positive and Negative Syndrome Scale (PANSS) was used to assess symptoms of schizophrenia. The Schedule for Assessing Insight (SAI) was used to assess patients′ insight and the Personal and Social Performance Scale (PSP) was used to assess their social functioning.

Results. Effect-size analysis showed that patients made rapid improvements in all symptoms, insight and social functioning as measured by the PANSS, SAI and PSP at 12 and 24 weeks and maintained these improvements over the course of the study to 84 weeks. Patients in the CBT group showed significantly greater and more durable improvement in PANSS total score (p = 0.045, between-group d = 0.48), positive symptoms (p = 0.018, between-group d = 0.42) and social functioning (p = 0.037, between-group d = 0.64), with significant differences emerging after completion of therapy.

Conclusions. Both CBT and ST combined with medication had benefits on psychopathology, insight and social functioning of patients with schizophrenia. CBT was significantly more effective than ST on overall, positive symptoms and social functioning of patients with schizophrenia in the long term.

语种: 英语
所属项目编号: D0906001040391 ; BIBD-PXM2013_014226_07_000084
项目资助者: Beijing Municipal Science &amp ; Technology Commission ; Beijing Institute for Brain Disorders
WOS记录号: WOS:000355754800010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54389
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Capital Med Univ, Beijing Anding Hosp, Dept Clin Psychol, Beijing Key Lab Mental Disorders, Beijing 100088, Peoples R China
2.Beijing Inst Brain Disorders, Ctr Schizophrenia, Beijing, Peoples R China
3.Beijing Huilongguan Hosp, Beijing, Peoples R China
4.Peking Univ, Hosp 6, Inst Mental Hlth, Beijing 100871, Peoples R China
5.Griffith Univ, Griffith Hlth Inst, Griffith, Qld 4222, Australia
6.Griffith Univ, Sch Med, Griffith, Qld 4222, Australia
7.Third Hosp Chaoyang Dist, Beijing, Peoples R China
8.Kowloon Hosp, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
9.Newcastle Univ, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
10.Univ Southampton, Southampton, Hants, England

Recommended Citation:
Li, Z. -J.,Guo, Z. -H.,Wang, N.,et al. Cognitive-behavioural therapy for patients with schizophrenia: a multicentre randomized controlled trial in Beijing, China[J]. PSYCHOLOGICAL MEDICINE,2015,45(9):1893-1905.
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