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Elevation of Serum Immunoglobulin Free Light Chains During the Preclinical Period of Rheumatoid Arthritis
Deng, Xiaoli1; Crowson, Cynthia S.; Rajkumar, S. Vincent; Dispenzieri, Angela; Larson, Dirk R.; Therneau, Terry M.; Matteson, Eric L.; Kyle, Robert A.; Katzmann, Jerry A.; Gabriel, Sherine E.; Davis, John M., III
关键词b Cell Biomarkers Autoimmunity Mortality
刊名JOURNAL OF RHEUMATOLOGY
2015-02-01
DOI10.3899/jrheum.140543
42期:2页:181-187
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Rheumatology
研究领域[WOS]Rheumatology
关键词[WOS]ROCHESTER EPIDEMIOLOGY PROJECT ; CYCLIC CITRULLINATED PEPTIDE ; SYSTEMIC-LUPUS-ERYTHEMATOSUS ; DISEASE-ACTIVITY ; DOUBLE-BLIND ; POPULATION ; RITUXIMAB ; EFFICACY ; PREVALENCE ; ANTIBODIES
英文摘要

Objective. Immunoglobulin free light chains (FLC) represent biomarkers of B cell activity in rheumatoid arthritis (RA) and are associated with all-cause mortality in the general population. Our objective was to evaluate the relationships of serum FLC to preclinical disease, RA characteristics, and mortality in RA compared to non-RA subjects.

Methods. A population-based study in Olmsted County, Minnesota, USA, was performed by crosslinking a large cohort in the general population having available serum FLC measurements with established RA incidence and prevalence cohorts. Serum kappa, lambda, and total FLC and their trends relative to RA incidence were compared between RA and non-RA subjects. Regression models were used to determine the associations between FLC, disease characteristics, and mortality, testing for differential effects of FLC on mortality in RA.

Results. Among 16,609 subjects, 270 fulfilled the criteria for RA at the time of FLC measurement. Mean total FLC were significantly higher in RA compared to non-RA subjects (4.2 vs 3.3 mg/dl, p < 0.001). FLC became elevated 3-5 years before the clinical onset of RA and remained elevated during followup. Polyclonal FLC were found to predict higher mortality in persons with RA, though elevation to the highest decile had a relatively lower effect on mortality in RA compared to non-RA subjects.

Conclusion. Elevation of serum FLC precedes the development of RA and may be useful in monitoring B cell activity and disease progression. FLC are associated with mortality among patients with RA as well as the general population.

语种英语
WOS记录号WOS:000349032200009
项目编号R01 AR46849 ; CA107476 ; CA168762 ; R01 AG034676
资助机构US National Institutes of Health ; National Institute for Arthritis, Musculoskeletal, and Skin Diseases ; National Cancer Institute ; National Institute for Aging ; Rochester Epidemiology Project ; Jabbs Foundation (Birmingham, UK) ; Henry J. Predolin Foundation, USA
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54392
专题北京大学第三临床医学院
作者单位1.Mayo Clin, Dept Med, Dept Hlth Sci Res, Rochester, MN 55905 USA
2.Mayo Clin, Dept Lab Med & Pathol, Rochester, MN 55905 USA
3.Peking Univ, Hosp 3, Dept Rheumatol & Immunol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Deng, Xiaoli,Crowson, Cynthia S.,Rajkumar, S. Vincent,et al. Elevation of Serum Immunoglobulin Free Light Chains During the Preclinical Period of Rheumatoid Arthritis[J]. JOURNAL OF RHEUMATOLOGY,2015,42(2):181-187.
APA Deng, Xiaoli.,Crowson, Cynthia S..,Rajkumar, S. Vincent.,Dispenzieri, Angela.,Larson, Dirk R..,...&Davis, John M., III.(2015).Elevation of Serum Immunoglobulin Free Light Chains During the Preclinical Period of Rheumatoid Arthritis.JOURNAL OF RHEUMATOLOGY,42(2),181-187.
MLA Deng, Xiaoli,et al."Elevation of Serum Immunoglobulin Free Light Chains During the Preclinical Period of Rheumatoid Arthritis".JOURNAL OF RHEUMATOLOGY 42.2(2015):181-187.
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