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学科主题: 临床医学
题名:
Elevation of Serum Immunoglobulin Free Light Chains During the Preclinical Period of Rheumatoid Arthritis
作者: Deng, Xiaoli1; Crowson, Cynthia S.; Rajkumar, S. Vincent; Dispenzieri, Angela; Larson, Dirk R.; Therneau, Terry M.; Matteson, Eric L.; Kyle, Robert A.; Katzmann, Jerry A.; Gabriel, Sherine E.; Davis, John M., III
关键词: B CELL ; BIOMARKERS ; AUTOIMMUNITY ; MORTALITY
刊名: JOURNAL OF RHEUMATOLOGY
发表日期: 2015-02-01
DOI: 10.3899/jrheum.140543
卷: 42, 期:2, 页:181-187
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Rheumatology
研究领域[WOS]: Rheumatology
关键词[WOS]: ROCHESTER EPIDEMIOLOGY PROJECT ; CYCLIC CITRULLINATED PEPTIDE ; SYSTEMIC-LUPUS-ERYTHEMATOSUS ; DISEASE-ACTIVITY ; DOUBLE-BLIND ; POPULATION ; RITUXIMAB ; EFFICACY ; PREVALENCE ; ANTIBODIES
英文摘要:

Objective. Immunoglobulin free light chains (FLC) represent biomarkers of B cell activity in rheumatoid arthritis (RA) and are associated with all-cause mortality in the general population. Our objective was to evaluate the relationships of serum FLC to preclinical disease, RA characteristics, and mortality in RA compared to non-RA subjects.

Methods. A population-based study in Olmsted County, Minnesota, USA, was performed by crosslinking a large cohort in the general population having available serum FLC measurements with established RA incidence and prevalence cohorts. Serum kappa, lambda, and total FLC and their trends relative to RA incidence were compared between RA and non-RA subjects. Regression models were used to determine the associations between FLC, disease characteristics, and mortality, testing for differential effects of FLC on mortality in RA.

Results. Among 16,609 subjects, 270 fulfilled the criteria for RA at the time of FLC measurement. Mean total FLC were significantly higher in RA compared to non-RA subjects (4.2 vs 3.3 mg/dl, p < 0.001). FLC became elevated 3-5 years before the clinical onset of RA and remained elevated during followup. Polyclonal FLC were found to predict higher mortality in persons with RA, though elevation to the highest decile had a relatively lower effect on mortality in RA compared to non-RA subjects.

Conclusion. Elevation of serum FLC precedes the development of RA and may be useful in monitoring B cell activity and disease progression. FLC are associated with mortality among patients with RA as well as the general population.

语种: 英语
所属项目编号: R01 AR46849 ; CA107476 ; CA168762 ; R01 AG034676
项目资助者: US National Institutes of Health ; National Institute for Arthritis, Musculoskeletal, and Skin Diseases ; National Cancer Institute ; National Institute for Aging ; Rochester Epidemiology Project ; Jabbs Foundation (Birmingham, UK) ; Henry J. Predolin Foundation, USA
WOS记录号: WOS:000349032200009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54392
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Mayo Clin, Dept Med, Dept Hlth Sci Res, Rochester, MN 55905 USA
2.Mayo Clin, Dept Lab Med & Pathol, Rochester, MN 55905 USA
3.Peking Univ, Hosp 3, Dept Rheumatol & Immunol, Beijing 100871, Peoples R China

Recommended Citation:
Deng, Xiaoli,Crowson, Cynthia S.,Rajkumar, S. Vincent,et al. Elevation of Serum Immunoglobulin Free Light Chains During the Preclinical Period of Rheumatoid Arthritis[J]. JOURNAL OF RHEUMATOLOGY,2015,42(2):181-187.
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