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学科主题: 临床医学
题名:
In vitro combined activity of amphotericin B, caspofungin and voriconazole against clinical isolates of Trichosporon asahii
作者: Li, Houmin1; Lu, Qiaoyun2,3; Wan, Zhe2,3; Zhang, Jianzhong1
关键词: Trichosporon asahii ; Antifungal susceptibility ; Drug interaction
刊名: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
发表日期: 2010-06-01
DOI: 10.1016/j.ijantimicag.2010.01.013
卷: 35, 期:6, 页:550-552
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Infectious Diseases ; Microbiology ; Pharmacology & Pharmacy
研究领域[WOS]: Infectious Diseases ; Microbiology ; Pharmacology & Pharmacy
关键词[WOS]: COMBINATION ; MICAFUNGIN ; INFECTION ; EFFICACY ; BEIGELII
英文摘要:

Disseminated infections caused by Trichosporon asahii are difficult to resolve. Combination regimens with synergistic drugs could provide additional options for treating trichosporonosis. The aim of this study was to evaluate the antifungal activities of voriconazole (VCZ), caspofungin (CAS) and amphotericin B (AMB) alone or in combination in vitro against clinical isolates of T. asahii. The combined antifungal activities of VCZ, CAS and AMB against 18 clinical isolates were assessed by a chequerboard microdilution method. CAS combined with AMB showed the highest percentage of synergistic effects (89%), much higher than those of the other two combinations (AMB/VCZ and CAS/VCZ both 17%). No antagonistic effect was observed in any case. This study demonstrates that the activity of two combined antifungals, especially the combination of CAS and AMB, against T. asahii is more effective than that of a drug alone against this fungus, suggesting that combined antifungal therapy may be a potential strategy for treating disseminated trichosporonosis. (C) 2010 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

语种: 英语
所属项目编号: 7073096
项目资助者: Beijing Natural Science Foundation ; Peking University People&prime ; s Hospital Internal Research Foundation
WOS记录号: WOS:000276717200007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54394
Appears in Collections:北京大学第二临床医学院_皮科_期刊论文

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作者单位: 1.Peking Univ, Res Ctr Med Mycol, Beijing 100044, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Dermatol, Beijing 100044, Peoples R China
3.Peking Univ, Hosp 1, Dept Dermatol, Beijing 100044, Peoples R China

Recommended Citation:
Li, Houmin,Lu, Qiaoyun,Wan, Zhe,et al. In vitro combined activity of amphotericin B, caspofungin and voriconazole against clinical isolates of Trichosporon asahii[J]. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS,2010,35(6):550-552.
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