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学科主题: 临床医学
题名:
Rs495828 polymorphism of the ABO gene is a predictor of enalapril-induced cough in Chinese patients with essential hypertension
作者: Luo, Jian-Quan1; He, Fa-Zhong1; Luo, Zhi-Ying1; Wen, Jia-Gen1; Wang, Lu-Yan2; Sun, Ning-Ling2; Tang, Gen-Fu3; Li, Qing1; Guo, Dong1; Liu, Zhao-Qian1; Zhou, Hong-Hao1; Chen, Xiao-Ping1; Zhang, Wei1
关键词: ABO ; cough ; enalapril ; essential hypertension ; polymorphism
刊名: PHARMACOGENETICS AND GENOMICS
发表日期: 2014-06-01
DOI: 10.1097/FPC.0000000000000050
卷: 24, 期:6, 页:306-313
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Genetics & Heredity ; Pharmacology & Pharmacy
研究领域[WOS]: Biotechnology & Applied Microbiology ; Genetics & Heredity ; Pharmacology & Pharmacy
关键词[WOS]: CONVERTING ENZYME-INHIBITORS ; GENOME-WIDE ASSOCIATION ; SOLUBLE E-SELECTIN ; REFLEX SENSITIVITY ; ACE ; LOCUS ; RISK ; SUSCEPTIBILITY ; METAANALYSIS ; VARIANTS
英文摘要:

ObjectiveABO genetic polymorphisms have recently been associated with angiotensin-converting enzyme (ACE) activity and inflammation, which play a critical role in the pathogenic mechanism of ACE inhibitor-induced cough. Therefore, the current study determined the association of ABO genetic polymorphisms with enalapril-induced cough in Chinese patients with essential hypertension.MethodsA total of 450 essential hypertensive patients treated with 10 mg of enalapril maleate were genotyped for ABO genetic polymorphisms using the PCR-direct sequencing method. Cough was recorded when patients were bothered by cough and respiratory symptoms during enalapril treatment without an identifiable cause.ResultsThe distribution of rs8176740 and rs495828 was different between the coughers and the controls [P=0.039; odds ratio (OR)=0.70, P=0.018; OR=1.41]. The risk of enalapril-induced cough in the rs495828 TT carriers was increased (P=0.008; OR=2.69), which remained significant after false discovery rate correction. The results for the rs8176740 polymorphism were significant in the female subgroup (P=0.027; OR=0.22). Haplotype analysis of the four ABO polymorphisms (rs8176746/rs8176740/rs495828/rs12683493) showed that the frequency of the GATC haplotype was higher in the coughers than those in the controls (26.6 vs. 18.8%, P=0.033; OR=1.43).ConclusionThe rs495828 polymorphism was associated with enalapril-induced cough and may serve as a useful pharmacogenomics marker of the safety of enalapril in Chinese patients with essential hypertension. The mechanism for the associations may involve the effects of the ABO gene or ABO blood type on ACE activity and inflammation. (C) 2014 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

语种: 英语
所属项目编号: 81273595 ; 81202594 ; 81001445 ; 2012AA02A517 ; 2012 AA02A518 ; 11K073 ; 10JJ4020 ; 13JJ1010 ; 2011JQ016
项目资助者: National Scientific Foundation of China ; &prime ; 863&prime ; Project ; Scientific Foundation of Hunan ; Hunan Provincial Natural Science Foundation of China
WOS记录号: WOS:000336260000003
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54397
Appears in Collections:北京大学第二临床医学院_心血管内科_期刊论文

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作者单位: 1.Anhui Med Univ, Sch Hlth Adm, Hefei, Peoples R China
2.Cent S Univ, Xiangya Hosp, Pharmacogenet & Pharmacogen Res Inst, Inst Clin Pharmacol,Hunan Key Lab Pharmacogenet, Changsha 410078, Hunan, Peoples R China
3.Peking Univ, Dept Cardiol, Peoples Hosp, Beijing 100871, Peoples R China

Recommended Citation:
Luo, Jian-Quan,He, Fa-Zhong,Luo, Zhi-Ying,et al. Rs495828 polymorphism of the ABO gene is a predictor of enalapril-induced cough in Chinese patients with essential hypertension[J]. PHARMACOGENETICS AND GENOMICS,2014,24(6):306-313.
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