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Rs495828 polymorphism of the ABO gene is a predictor of enalapril-induced cough in Chinese patients with essential hypertension
Luo, Jian-Quan1; He, Fa-Zhong1; Luo, Zhi-Ying1; Wen, Jia-Gen1; Wang, Lu-Yan2; Sun, Ning-Ling2; Tang, Gen-Fu3; Li, Qing1; Guo, Dong1; Liu, Zhao-Qian1; Zhou, Hong-Hao1; Chen, Xiao-Ping1; Zhang, Wei1
关键词Abo Cough Enalapril Essential Hypertension Polymorphism
刊名PHARMACOGENETICS AND GENOMICS
2014-06-01
DOI10.1097/FPC.0000000000000050
24期:6页:306-313
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Genetics & Heredity ; Pharmacology & Pharmacy
研究领域[WOS]Biotechnology & Applied Microbiology ; Genetics & Heredity ; Pharmacology & Pharmacy
关键词[WOS]CONVERTING ENZYME-INHIBITORS ; GENOME-WIDE ASSOCIATION ; SOLUBLE E-SELECTIN ; REFLEX SENSITIVITY ; ACE ; LOCUS ; RISK ; SUSCEPTIBILITY ; METAANALYSIS ; VARIANTS
英文摘要

ObjectiveABO genetic polymorphisms have recently been associated with angiotensin-converting enzyme (ACE) activity and inflammation, which play a critical role in the pathogenic mechanism of ACE inhibitor-induced cough. Therefore, the current study determined the association of ABO genetic polymorphisms with enalapril-induced cough in Chinese patients with essential hypertension.MethodsA total of 450 essential hypertensive patients treated with 10 mg of enalapril maleate were genotyped for ABO genetic polymorphisms using the PCR-direct sequencing method. Cough was recorded when patients were bothered by cough and respiratory symptoms during enalapril treatment without an identifiable cause.ResultsThe distribution of rs8176740 and rs495828 was different between the coughers and the controls [P=0.039; odds ratio (OR)=0.70, P=0.018; OR=1.41]. The risk of enalapril-induced cough in the rs495828 TT carriers was increased (P=0.008; OR=2.69), which remained significant after false discovery rate correction. The results for the rs8176740 polymorphism were significant in the female subgroup (P=0.027; OR=0.22). Haplotype analysis of the four ABO polymorphisms (rs8176746/rs8176740/rs495828/rs12683493) showed that the frequency of the GATC haplotype was higher in the coughers than those in the controls (26.6 vs. 18.8%, P=0.033; OR=1.43).ConclusionThe rs495828 polymorphism was associated with enalapril-induced cough and may serve as a useful pharmacogenomics marker of the safety of enalapril in Chinese patients with essential hypertension. The mechanism for the associations may involve the effects of the ABO gene or ABO blood type on ACE activity and inflammation. (C) 2014 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

语种英语
WOS记录号WOS:000336260000003
项目编号81273595 ; 81202594 ; 81001445 ; 2012AA02A517 ; 2012 AA02A518 ; 11K073 ; 10JJ4020 ; 13JJ1010 ; 2011JQ016
资助机构National Scientific Foundation of China ; &prime ; 863&prime ; Project ; Scientific Foundation of Hunan ; Hunan Provincial Natural Science Foundation of China
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54397
专题北京大学第二临床医学院_心血管内科
作者单位1.Anhui Med Univ, Sch Hlth Adm, Hefei, Peoples R China
2.Cent S Univ, Xiangya Hosp, Pharmacogenet & Pharmacogen Res Inst, Inst Clin Pharmacol,Hunan Key Lab Pharmacogenet, Changsha 410078, Hunan, Peoples R China
3.Peking Univ, Dept Cardiol, Peoples Hosp, Beijing 100871, Peoples R China
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Luo, Jian-Quan,He, Fa-Zhong,Luo, Zhi-Ying,et al. Rs495828 polymorphism of the ABO gene is a predictor of enalapril-induced cough in Chinese patients with essential hypertension[J]. PHARMACOGENETICS AND GENOMICS,2014,24(6):306-313.
APA Luo, Jian-Quan.,He, Fa-Zhong.,Luo, Zhi-Ying.,Wen, Jia-Gen.,Wang, Lu-Yan.,...&Zhang, Wei.(2014).Rs495828 polymorphism of the ABO gene is a predictor of enalapril-induced cough in Chinese patients with essential hypertension.PHARMACOGENETICS AND GENOMICS,24(6),306-313.
MLA Luo, Jian-Quan,et al."Rs495828 polymorphism of the ABO gene is a predictor of enalapril-induced cough in Chinese patients with essential hypertension".PHARMACOGENETICS AND GENOMICS 24.6(2014):306-313.
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