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学科主题: 临床医学
题名:
Prevalence of specific and phylogenetically closely related genotypes in the population of Candida albicans associated with genital candidiasis in China
作者: Ge, Shu-Hua1,2; Xie, Jing1,2; Xu, Jianping1,3; Li, Juan1,4; Li, Dong-Ming5; Zong, Li-Li6; Zheng, Yue-Chen7; Bai, Feng-Yan1
关键词: Candida albicans ; Vulvovaginal candidiasis ; MLST ; Microsatellite typing ; Phylogeny
刊名: FUNGAL GENETICS AND BIOLOGY
发表日期: 2012
DOI: 10.1016/j.fgb.2011.10.006
卷: 49, 期:1, 页:86-93
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Genetics & Heredity ; Mycology
研究领域[WOS]: Genetics & Heredity ; Mycology
关键词[WOS]: VULVO-VAGINAL CANDIDIASIS ; BLOOD-STREAM ; SEQUENCE ; STRAINS ; MICROSATELLITE ; RECURRENT ; VAGINITIS ; SUSCEPTIBILITY ; POLYMORPHISM ; INFECTIONS
英文摘要:

Genitourinary candidiasis, which is most frequently caused by Candida albicans, is a common problem worldwide. The pathogenesis of the infection, especially recurrence of the infection, remains to be elucidated. This study analyzed 199 independent Chinese C albicans isolates using multilocus sequence typing (MIST) and microsatellite typing, with the focus on the isolates associated with vulvovaginal candidiasis (VVC) of Chinese women. MIST data of 221 vaginal isolates from other countries available from the consensus MLST database of C. albicans were retrieved for comparison. A total of 124 diploid sequence types (DSTs) were recognized from the Chinese C albicans isolates, among which, 98 (79.0%) have not been reported in the MIST database of the species. The majority of the VVC (71.6%) and balanitis (92.3%) isolates from China were located in clade 1 of C. albicans; while only 40.6% of the vaginal isolates and 7.8% of the oral isolates from healthy volunteers were found in the same clade. Furthermore, 69.1% of the VVC and 84.5% of the balanitis isolates concentrated in a cluster of clade 1 with DST 79 as the primary founder. The isolates in this cluster possessed microsatellite genotypes CAI 30-45, CAI 32-46 and their close derivatives. Interestingly, a remarkable difference in genotype distribution patterns between Chinese and non-Chinese vaginal isolates of C albicans was observed. Only 11.3% of the non-Chinese vaginal isolates compared were located in the cluster concentrated with Chinese WC isolates. The results suggest significant association of specific and genetically similar genotypes with genital infections in China. (C) 2011 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 30825002 ; 30470048
项目资助者: National Natural Science Foundation of China (NSFC)
WOS记录号: WOS:000300742900010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54398
Appears in Collections:北京大学第三临床医学院_皮肤科_期刊论文

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作者单位: 1.McMaster Univ, Dept Biol, Hamilton, ON L8S 4K1, Canada
2.Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol, Beijing 100101, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
4.Chinese Ctr Dis Control & Prevent, Natl Inst Communicable Dis Control & Prevent, State Key Lab Infect Dis Prevent & Control, Beijing 102206, Peoples R China
5.Peking Univ, Hosp 3, Dept Dermatol, Beijing 100191, Peoples R China
6.So Med Univ Hosp Integrated Chinese & Western Med, Dept Gynecol, Guangzhou 510320, Guangdong, Peoples R China
7.Union Hosp, Dept Dermatol & Venereol, Wuhan 430022, Hubei, Peoples R China

Recommended Citation:
Ge, Shu-Hua,Xie, Jing,Xu, Jianping,et al. Prevalence of specific and phylogenetically closely related genotypes in the population of Candida albicans associated with genital candidiasis in China[J]. FUNGAL GENETICS AND BIOLOGY,2012,49(1):86-93.
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