IR@PKUHSC  > 北京大学第三临床医学院  > 皮肤科
学科主题临床医学
Prevalence of specific and phylogenetically closely related genotypes in the population of Candida albicans associated with genital candidiasis in China
Ge, Shu-Hua1,2; Xie, Jing1,2; Xu, Jianping1,3; Li, Juan1,4; Li, Dong-Ming5; Zong, Li-Li6; Zheng, Yue-Chen7; Bai, Feng-Yan1
关键词Candida Albicans Vulvovaginal Candidiasis Mlst Microsatellite Typing Phylogeny
刊名FUNGAL GENETICS AND BIOLOGY
2012
DOI10.1016/j.fgb.2011.10.006
49期:1页:86-93
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity ; Mycology
资助者National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC)
研究领域[WOS]Genetics & Heredity ; Mycology
关键词[WOS]VULVO-VAGINAL CANDIDIASIS ; BLOOD-STREAM ; SEQUENCE ; STRAINS ; MICROSATELLITE ; RECURRENT ; VAGINITIS ; SUSCEPTIBILITY ; POLYMORPHISM ; INFECTIONS
英文摘要

Genitourinary candidiasis, which is most frequently caused by Candida albicans, is a common problem worldwide. The pathogenesis of the infection, especially recurrence of the infection, remains to be elucidated. This study analyzed 199 independent Chinese C albicans isolates using multilocus sequence typing (MIST) and microsatellite typing, with the focus on the isolates associated with vulvovaginal candidiasis (VVC) of Chinese women. MIST data of 221 vaginal isolates from other countries available from the consensus MLST database of C. albicans were retrieved for comparison. A total of 124 diploid sequence types (DSTs) were recognized from the Chinese C albicans isolates, among which, 98 (79.0%) have not been reported in the MIST database of the species. The majority of the VVC (71.6%) and balanitis (92.3%) isolates from China were located in clade 1 of C. albicans; while only 40.6% of the vaginal isolates and 7.8% of the oral isolates from healthy volunteers were found in the same clade. Furthermore, 69.1% of the VVC and 84.5% of the balanitis isolates concentrated in a cluster of clade 1 with DST 79 as the primary founder. The isolates in this cluster possessed microsatellite genotypes CAI 30-45, CAI 32-46 and their close derivatives. Interestingly, a remarkable difference in genotype distribution patterns between Chinese and non-Chinese vaginal isolates of C albicans was observed. Only 11.3% of the non-Chinese vaginal isolates compared were located in the cluster concentrated with Chinese WC isolates. The results suggest significant association of specific and genetically similar genotypes with genital infections in China. (C) 2011 Elsevier Inc. All rights reserved.

语种英语
所属项目编号30825002 ; 30470048
资助者National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC)
WOS记录号WOS:000300742900010
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54398
专题北京大学第三临床医学院_皮肤科
作者单位1.McMaster Univ, Dept Biol, Hamilton, ON L8S 4K1, Canada
2.Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol, Beijing 100101, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
4.Chinese Ctr Dis Control & Prevent, Natl Inst Communicable Dis Control & Prevent, State Key Lab Infect Dis Prevent & Control, Beijing 102206, Peoples R China
5.Peking Univ, Hosp 3, Dept Dermatol, Beijing 100191, Peoples R China
6.So Med Univ Hosp Integrated Chinese & Western Med, Dept Gynecol, Guangzhou 510320, Guangdong, Peoples R China
7.Union Hosp, Dept Dermatol & Venereol, Wuhan 430022, Hubei, Peoples R China
推荐引用方式
GB/T 7714
Ge, Shu-Hua,Xie, Jing,Xu, Jianping,et al. Prevalence of specific and phylogenetically closely related genotypes in the population of Candida albicans associated with genital candidiasis in China[J]. FUNGAL GENETICS AND BIOLOGY,2012,49(1):86-93.
APA Ge, Shu-Hua.,Xie, Jing.,Xu, Jianping.,Li, Juan.,Li, Dong-Ming.,...&Bai, Feng-Yan.(2012).Prevalence of specific and phylogenetically closely related genotypes in the population of Candida albicans associated with genital candidiasis in China.FUNGAL GENETICS AND BIOLOGY,49(1),86-93.
MLA Ge, Shu-Hua,et al."Prevalence of specific and phylogenetically closely related genotypes in the population of Candida albicans associated with genital candidiasis in China".FUNGAL GENETICS AND BIOLOGY 49.1(2012):86-93.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Ge, Shu-Hua]的文章
[Xie, Jing]的文章
[Xu, Jianping]的文章
百度学术
百度学术中相似的文章
[Ge, Shu-Hua]的文章
[Xie, Jing]的文章
[Xu, Jianping]的文章
必应学术
必应学术中相似的文章
[Ge, Shu-Hua]的文章
[Xie, Jing]的文章
[Xu, Jianping]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。