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学科主题: 临床医学
题名:
Single Nucleotide Polymorphism WRN Leu1074Phe Is Associated with Prostate Cancer Susceptibility in Chinese Subjects
作者: Wang, Lei1; Kaku, Haruki3,4; Huang, Peng3,4; Xu, Kexin1; Yang, Kai6; Zhang, Jiheng7; Li, Ming7; Xie, Liping6; Wang, Xiaofeng1; Sakai, Akiko5; Watanabe, Masami3,4; Nasu, Yasutomo2,3; Shimizu, Kenji5; Kumon, Hiromi3,4; Na, Yanqun1
关键词: polymorphism ; prostatic neoplasms ; single nucleotide ; susceptibility ; WRN
刊名: ACTA MEDICA OKAYAMA
发表日期: 2011-10-01
卷: 65, 期:5, 页:315-323
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: BREAST-CANCER ; DNA-REPAIR ; WERNER ; GENE ; EPIDEMIOLOGY ; VARIANT
英文摘要:

Deficiencies in the human DNA repair gene WRN are the cause of Werner syndrome, a rare autosomal recessive disorder characterized by premature aging and a predisposition to cancer. This study evaluated the association of WRN Leu1074Phe (rs1801195), a common missense single nucleotide polymorphism in WRN, with prostate cancer susceptibility in Chinese subjects. One hundred and forty-seven prostate cancer patients and 111 male cancer-free control subjects from 3 university hospitals in China were included. Blood samples were obtained from each subject, and the single nucleotide polymorphism WRN Leu1074Phe was genotyped by using a Snapshot assay. The results showed that WRN Leu1074Phe was associated with the risk of prostate cancer in Chinese men and that the TG/GG genotype displayed a decreased prevalence of prostate cancer compared with the TT genotype (OR = 0.58, 95% CI: 0.35-0.97, p = 0.039). Through stratified analysis, more significant associations were revealed for the TG/GG genotype in the subgroup with diagnosis age <= 72 yr (OR = 0.27, 95% CI: 0.12-0.61, p = 0.002) and in patients with localized diseases (OR = 0.36, 95% CI: 0.19-0.70, p = 0.003). However, no statistically significant difference was found in the subgroup with age > 72 yr or in patients with advanced diseases. We concluded that the genetic variant Leu1074Phe in the DNA repair gene WRN might play a role in the risk of prostate cancer in Chinese subjects.

语种: 英语
WOS记录号: WOS:000296116400005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54399
Appears in Collections:北京大学第二临床医学院_泌尿外科_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Dept Urol, Beijing 100044, Peoples R China
2.Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Res & Dev Ctr Adv Clin Med, Okayama 7008558, Japan
3.Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Urol, Okayama 7008558, Japan
4.Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Ctr Gene & Cell Therapy, Okayama 7008558, Japan
5.Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Mol Genet, Okayama 7008558, Japan
6.Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Urol, Hangzhou 310003, Zhejiang, Peoples R China
7.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Dept Urol, Beijing 100142, Peoples R China

Recommended Citation:
Wang, Lei,Kaku, Haruki,Huang, Peng,et al. Single Nucleotide Polymorphism WRN Leu1074Phe Is Associated with Prostate Cancer Susceptibility in Chinese Subjects[J]. ACTA MEDICA OKAYAMA,2011,65(5):315-323.
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